TY - JOUR
T1 - Hepatocellular carcinoma
T2 - Correlation of CT, angiographic, and histopathologic findings
AU - Honda, Hiroshi
AU - Ochiai, Kouichirou
AU - Adachi, Eisuke
AU - Yasumori, Koutarou
AU - Hayashi, Takamoto
AU - Kawashima, Akira
AU - Fukuya, Tatsurou
AU - Gibo, Masaki
AU - Matsumata, Takashi
AU - Tsuneyoshi, Masazumi
AU - Masuda, Kouji
PY - 1993/12
Y1 - 1993/12
N2 - PURPOSE: To elucidate the causes of various enhancement patterns of hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: Computed tomographic (CT) scans of 68 surgically resected HCCs (62 patients) were obtained 45 seconds and 6 minutes after administration of contrast material. These scans were compared with angiographic and histopathologic findings. RESULTS: On the early images, 24 HCCs (35%) were hypoattenuating, 33 were totally or partially hyperattenuating (48%), and 11 were isoattenuating (16%) compared to adjacent liver. On the delayed images, 55 HCCs (81%) were hypoattenuating and 13 (19%) were isoattenuating. Twenty-nine of the 48 very hypervascular or hypervascular tumors (60%) were hyperattenuating or partially hyperattenuating at early CT. Sixteen of the 20 slightly hypervascular or hypovascular tumors (80%) were isoattenuating or hypoattenuating. CONCLUSION: Although there was relatively good agreement between tumor vascularity and enhancement pattern (60% correlation for hypervascular tumors, 80% correlation for hypovascular tumors), hyperattenuation of the large HCCs (≥5 cm) at CT appeared to be a function of dilated sinusoids within the tumor (peliotic changes) as well as vascularity. In patients with advanced cirrhosis, hypovascular HCCs could be hyperattenuating at CT.
AB - PURPOSE: To elucidate the causes of various enhancement patterns of hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: Computed tomographic (CT) scans of 68 surgically resected HCCs (62 patients) were obtained 45 seconds and 6 minutes after administration of contrast material. These scans were compared with angiographic and histopathologic findings. RESULTS: On the early images, 24 HCCs (35%) were hypoattenuating, 33 were totally or partially hyperattenuating (48%), and 11 were isoattenuating (16%) compared to adjacent liver. On the delayed images, 55 HCCs (81%) were hypoattenuating and 13 (19%) were isoattenuating. Twenty-nine of the 48 very hypervascular or hypervascular tumors (60%) were hyperattenuating or partially hyperattenuating at early CT. Sixteen of the 20 slightly hypervascular or hypovascular tumors (80%) were isoattenuating or hypoattenuating. CONCLUSION: Although there was relatively good agreement between tumor vascularity and enhancement pattern (60% correlation for hypervascular tumors, 80% correlation for hypovascular tumors), hyperattenuation of the large HCCs (≥5 cm) at CT appeared to be a function of dilated sinusoids within the tumor (peliotic changes) as well as vascularity. In patients with advanced cirrhosis, hypovascular HCCs could be hyperattenuating at CT.
KW - Liver neoplasms, 761.321
KW - Liver neoplasms, diagnosis, 761.12113, 761.12114
KW - Liver, CT, 761.12113, 761.12114
KW - Liver, angiography, 761.1242
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U2 - 10.1148/radiology.189.3.8234716
DO - 10.1148/radiology.189.3.8234716
M3 - Article
C2 - 8234716
AN - SCOPUS:0027333494
SN - 0033-8419
VL - 189
SP - 857
EP - 862
JO - Radiology
JF - Radiology
IS - 3
ER -