Hepatitis C Virus Recurrence in Living Donor Liver Transplant Recipients

Hector Rodriguez-Luna, Hugo E. Vargas, Pratima Sharma, Jose Ortiz, Giovanni De Petris, Vijayan Balan, Thomas Byrne, Adyr Moss, David Mulligan, Jorge Rakela, David D. Douglas

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Recurrence of hepatitis C virus (HCV) after liver transplantation (LT) is a universal phenomenon. Recent reports have suggested an earlier and more aggressive recurrence in the living donor liver transplant (LDLT) population. The aim of this study was to compare the histological recurrence of HCV after LDLT versus deceased donor transplantation (DDT). Twenty-nine patients underwent LT for HCV-related end-stage liver disease at our institution between April 2001 and March 2003 (42 months). Twenty patients underwent DDT, and nine patients LDLT. Laboratory data were collected on a weekly to biweekly basis and HCV PCR was performed before LT and 3-4 months and yearly post-LT. Liver biopsies were performed as needed and per institutional protocol at 7 days, at 4 months, and yearly thereafter. All biopsies were evaluated by a single pathologist and scored for rejection (Banff score) and chronic hepatitis (Ishak score system). The predominant genotype in the DDT and LDLT groups was genotype 1 (DDT = 70%, LDLT = 79%). HCV RNA titers pre-LT and 3-4 months after LT did not differ. The incidence of rejection was higher in the DDT group (P < 0.05). There was a trend toward improved Ishak stage and grade in the LDLT group at 4 and 12 months post-LT, however, this trend did not reach statistical significance. No histological difference in the recurrence or severity rate was observed at 4 or 12 months post-LT in the DDT group vs. the LDLT group.

Original languageEnglish (US)
Pages (from-to)38-41
Number of pages4
JournalDigestive diseases and sciences
Volume49
Issue number1
DOIs
StatePublished - Jan 1 2004

Keywords

  • Deceased donor liver transplant
  • End-stage liver disease
  • Hepatitis C virus
  • Living donor liver transplant
  • Recurrence

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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    Rodriguez-Luna, H., Vargas, H. E., Sharma, P., Ortiz, J., De Petris, G., Balan, V., Byrne, T., Moss, A., Mulligan, D., Rakela, J., & Douglas, D. D. (2004). Hepatitis C Virus Recurrence in Living Donor Liver Transplant Recipients. Digestive diseases and sciences, 49(1), 38-41. https://doi.org/10.1023/B:DDAS.0000011599.78222.9e