Hepatitis C and Non-Hodgkin Lymphoma Among 4784 Cases and 6269 Controls From the International Lymphoma Epidemiology Consortium

Silvia De Sanjose, Yolanda Benavente, Claire M. Vajdic, Eric A. Engels, Lindsay M. Morton, Paige M. Bracci, John J. Spinelli, Tongzhang Zheng, Yawei Zhang, Silvia Franceschi, Renato Talamini, Elizabeth A. Holly, Andrew E. Grulich, James R Cerhan, Patricia Hartge, Wendy Cozen, Paolo Boffetta, Paul Brennan, Marc Maynadié, Pierluigi CoccoRamon Bosch, Lenka Foretova, Anthony Staines, Nikolaus Becker, Alexandra Nieters

Research output: Contribution to journalArticle

224 Citations (Scopus)

Abstract

Background & Aims: Increasing evidence points towards a role of hepatitis C virus (HCV) infection in causing malignant lymphomas. We pooled case-control study data to provide robust estimates of the risk of non-Hodgkin's lymphoma (NHL) subtypes after HCV infection. Methods: The analysis included 7 member studies from the International Lymphoma Epidemiology Consortium (InterLymph) based in Europe, North America, and Australia. Adult cases of NHL (n = 4784) were diagnosed between 1988 and 2004 and controls (n = 6269) were matched by age, sex, and study center. All studies used third-generation enzyme-linked immunosorbent assays to test for antibodies against HCV in serum samples. Participants who were human immunodeficiency virus positive or were organ-transplant recipients were excluded. Results: HCV infection was detected in 172 NHL cases (3.60%) and in 169 (2.70%) controls (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.40-2.25). In subtype-specific analyses, HCV prevalence was associated with marginal zone lymphoma (OR, 2.47; 95% CI, 1.44-4.23), diffuse large B-cell lymphoma (OR, 2.24; 95% CI, 1.68-2.99), and lymphoplasmacytic lymphoma (OR, 2.57; 95% CI, 1.14-5.79). Notably, risk estimates were not increased for follicular lymphoma (OR, 1.02; 95% CI, 0.65-1.60). Conclusions: These results confirm the association between HCV infection and NHL and specific B-NHL subtypes (diffuse large B-cell lymphoma, marginal zone lymphoma, and lymphoplasmacytic lymphoma).

Original languageEnglish (US)
Pages (from-to)451-458
Number of pages8
JournalClinical Gastroenterology and Hepatology
Volume6
Issue number4
DOIs
StatePublished - Apr 2008

Fingerprint

Hepatitis C
Non-Hodgkin's Lymphoma
Lymphoma
Epidemiology
Hepacivirus
Virus Diseases
Odds Ratio
Confidence Intervals
Marginal Zone B-Cell Lymphoma
Follicular Lymphoma
Hepatitis C Antibodies
Lymphoma, Large B-Cell, Diffuse
North America
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
HIV
Transplants
Serum

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Hepatitis C and Non-Hodgkin Lymphoma Among 4784 Cases and 6269 Controls From the International Lymphoma Epidemiology Consortium. / De Sanjose, Silvia; Benavente, Yolanda; Vajdic, Claire M.; Engels, Eric A.; Morton, Lindsay M.; Bracci, Paige M.; Spinelli, John J.; Zheng, Tongzhang; Zhang, Yawei; Franceschi, Silvia; Talamini, Renato; Holly, Elizabeth A.; Grulich, Andrew E.; Cerhan, James R; Hartge, Patricia; Cozen, Wendy; Boffetta, Paolo; Brennan, Paul; Maynadié, Marc; Cocco, Pierluigi; Bosch, Ramon; Foretova, Lenka; Staines, Anthony; Becker, Nikolaus; Nieters, Alexandra.

In: Clinical Gastroenterology and Hepatology, Vol. 6, No. 4, 04.2008, p. 451-458.

Research output: Contribution to journalArticle

De Sanjose, S, Benavente, Y, Vajdic, CM, Engels, EA, Morton, LM, Bracci, PM, Spinelli, JJ, Zheng, T, Zhang, Y, Franceschi, S, Talamini, R, Holly, EA, Grulich, AE, Cerhan, JR, Hartge, P, Cozen, W, Boffetta, P, Brennan, P, Maynadié, M, Cocco, P, Bosch, R, Foretova, L, Staines, A, Becker, N & Nieters, A 2008, 'Hepatitis C and Non-Hodgkin Lymphoma Among 4784 Cases and 6269 Controls From the International Lymphoma Epidemiology Consortium', Clinical Gastroenterology and Hepatology, vol. 6, no. 4, pp. 451-458. https://doi.org/10.1016/j.cgh.2008.02.011
De Sanjose, Silvia ; Benavente, Yolanda ; Vajdic, Claire M. ; Engels, Eric A. ; Morton, Lindsay M. ; Bracci, Paige M. ; Spinelli, John J. ; Zheng, Tongzhang ; Zhang, Yawei ; Franceschi, Silvia ; Talamini, Renato ; Holly, Elizabeth A. ; Grulich, Andrew E. ; Cerhan, James R ; Hartge, Patricia ; Cozen, Wendy ; Boffetta, Paolo ; Brennan, Paul ; Maynadié, Marc ; Cocco, Pierluigi ; Bosch, Ramon ; Foretova, Lenka ; Staines, Anthony ; Becker, Nikolaus ; Nieters, Alexandra. / Hepatitis C and Non-Hodgkin Lymphoma Among 4784 Cases and 6269 Controls From the International Lymphoma Epidemiology Consortium. In: Clinical Gastroenterology and Hepatology. 2008 ; Vol. 6, No. 4. pp. 451-458.
@article{8377f84552984372a4afc783b299fba3,
title = "Hepatitis C and Non-Hodgkin Lymphoma Among 4784 Cases and 6269 Controls From the International Lymphoma Epidemiology Consortium",
abstract = "Background & Aims: Increasing evidence points towards a role of hepatitis C virus (HCV) infection in causing malignant lymphomas. We pooled case-control study data to provide robust estimates of the risk of non-Hodgkin's lymphoma (NHL) subtypes after HCV infection. Methods: The analysis included 7 member studies from the International Lymphoma Epidemiology Consortium (InterLymph) based in Europe, North America, and Australia. Adult cases of NHL (n = 4784) were diagnosed between 1988 and 2004 and controls (n = 6269) were matched by age, sex, and study center. All studies used third-generation enzyme-linked immunosorbent assays to test for antibodies against HCV in serum samples. Participants who were human immunodeficiency virus positive or were organ-transplant recipients were excluded. Results: HCV infection was detected in 172 NHL cases (3.60{\%}) and in 169 (2.70{\%}) controls (odds ratio [OR], 1.78; 95{\%} confidence interval [CI], 1.40-2.25). In subtype-specific analyses, HCV prevalence was associated with marginal zone lymphoma (OR, 2.47; 95{\%} CI, 1.44-4.23), diffuse large B-cell lymphoma (OR, 2.24; 95{\%} CI, 1.68-2.99), and lymphoplasmacytic lymphoma (OR, 2.57; 95{\%} CI, 1.14-5.79). Notably, risk estimates were not increased for follicular lymphoma (OR, 1.02; 95{\%} CI, 0.65-1.60). Conclusions: These results confirm the association between HCV infection and NHL and specific B-NHL subtypes (diffuse large B-cell lymphoma, marginal zone lymphoma, and lymphoplasmacytic lymphoma).",
author = "{De Sanjose}, Silvia and Yolanda Benavente and Vajdic, {Claire M.} and Engels, {Eric A.} and Morton, {Lindsay M.} and Bracci, {Paige M.} and Spinelli, {John J.} and Tongzhang Zheng and Yawei Zhang and Silvia Franceschi and Renato Talamini and Holly, {Elizabeth A.} and Grulich, {Andrew E.} and Cerhan, {James R} and Patricia Hartge and Wendy Cozen and Paolo Boffetta and Paul Brennan and Marc Maynadi{\'e} and Pierluigi Cocco and Ramon Bosch and Lenka Foretova and Anthony Staines and Nikolaus Becker and Alexandra Nieters",
year = "2008",
month = "4",
doi = "10.1016/j.cgh.2008.02.011",
language = "English (US)",
volume = "6",
pages = "451--458",
journal = "Clinical Gastroenterology and Hepatology",
issn = "1542-3565",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Hepatitis C and Non-Hodgkin Lymphoma Among 4784 Cases and 6269 Controls From the International Lymphoma Epidemiology Consortium

AU - De Sanjose, Silvia

AU - Benavente, Yolanda

AU - Vajdic, Claire M.

AU - Engels, Eric A.

AU - Morton, Lindsay M.

AU - Bracci, Paige M.

AU - Spinelli, John J.

AU - Zheng, Tongzhang

AU - Zhang, Yawei

AU - Franceschi, Silvia

AU - Talamini, Renato

AU - Holly, Elizabeth A.

AU - Grulich, Andrew E.

AU - Cerhan, James R

AU - Hartge, Patricia

AU - Cozen, Wendy

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - Maynadié, Marc

AU - Cocco, Pierluigi

AU - Bosch, Ramon

AU - Foretova, Lenka

AU - Staines, Anthony

AU - Becker, Nikolaus

AU - Nieters, Alexandra

PY - 2008/4

Y1 - 2008/4

N2 - Background & Aims: Increasing evidence points towards a role of hepatitis C virus (HCV) infection in causing malignant lymphomas. We pooled case-control study data to provide robust estimates of the risk of non-Hodgkin's lymphoma (NHL) subtypes after HCV infection. Methods: The analysis included 7 member studies from the International Lymphoma Epidemiology Consortium (InterLymph) based in Europe, North America, and Australia. Adult cases of NHL (n = 4784) were diagnosed between 1988 and 2004 and controls (n = 6269) were matched by age, sex, and study center. All studies used third-generation enzyme-linked immunosorbent assays to test for antibodies against HCV in serum samples. Participants who were human immunodeficiency virus positive or were organ-transplant recipients were excluded. Results: HCV infection was detected in 172 NHL cases (3.60%) and in 169 (2.70%) controls (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.40-2.25). In subtype-specific analyses, HCV prevalence was associated with marginal zone lymphoma (OR, 2.47; 95% CI, 1.44-4.23), diffuse large B-cell lymphoma (OR, 2.24; 95% CI, 1.68-2.99), and lymphoplasmacytic lymphoma (OR, 2.57; 95% CI, 1.14-5.79). Notably, risk estimates were not increased for follicular lymphoma (OR, 1.02; 95% CI, 0.65-1.60). Conclusions: These results confirm the association between HCV infection and NHL and specific B-NHL subtypes (diffuse large B-cell lymphoma, marginal zone lymphoma, and lymphoplasmacytic lymphoma).

AB - Background & Aims: Increasing evidence points towards a role of hepatitis C virus (HCV) infection in causing malignant lymphomas. We pooled case-control study data to provide robust estimates of the risk of non-Hodgkin's lymphoma (NHL) subtypes after HCV infection. Methods: The analysis included 7 member studies from the International Lymphoma Epidemiology Consortium (InterLymph) based in Europe, North America, and Australia. Adult cases of NHL (n = 4784) were diagnosed between 1988 and 2004 and controls (n = 6269) were matched by age, sex, and study center. All studies used third-generation enzyme-linked immunosorbent assays to test for antibodies against HCV in serum samples. Participants who were human immunodeficiency virus positive or were organ-transplant recipients were excluded. Results: HCV infection was detected in 172 NHL cases (3.60%) and in 169 (2.70%) controls (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.40-2.25). In subtype-specific analyses, HCV prevalence was associated with marginal zone lymphoma (OR, 2.47; 95% CI, 1.44-4.23), diffuse large B-cell lymphoma (OR, 2.24; 95% CI, 1.68-2.99), and lymphoplasmacytic lymphoma (OR, 2.57; 95% CI, 1.14-5.79). Notably, risk estimates were not increased for follicular lymphoma (OR, 1.02; 95% CI, 0.65-1.60). Conclusions: These results confirm the association between HCV infection and NHL and specific B-NHL subtypes (diffuse large B-cell lymphoma, marginal zone lymphoma, and lymphoplasmacytic lymphoma).

UR - http://www.scopus.com/inward/record.url?scp=41349088895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41349088895&partnerID=8YFLogxK

U2 - 10.1016/j.cgh.2008.02.011

DO - 10.1016/j.cgh.2008.02.011

M3 - Article

C2 - 18387498

AN - SCOPUS:41349088895

VL - 6

SP - 451

EP - 458

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

SN - 1542-3565

IS - 4

ER -