Hepatitis a virus infection in fulminant hepatitis and chronic active hepatitis

Jorge Rakela, Allan G. Redeker, Virginia M. Edwards, Richard Decker, Lacy R. Overby, James W. Mosley

Research output: Contribution to journalArticle

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Abstract

We looked for hepatitis A virus (HAV) infection as an etiological agent among patients with fulminant hepatitis and chronic active hepatitis. Among 42 patients with hepatitis B surface antigen (HBsAg)-negative fulminant disease, we detected seroconversion by immune adherence hemagglutination for antibody to HAV (anti-HAV) in 3 of 10 survivors, as well as an increasing anti-HAV score by immune electron microscopy. In the 32 HBsAg-negative nonsurvivors, we found 3 patients with anti-HAV detectable by immune electron microscopy and radioimmunoassay, but not by immune adherence hemagglutination. We classified the latter cases as presumptively attributable to HAV. In 10 survivors among 30 HBsAg-positive patients with fulminant disease, we did not detect any instances of anti-HAV seroconversion. In the 20 HBsAg-positive nonsurvivors, 1 case had anti-HAV detectable by immune electron microscopy and radioimmunoassay but not by immune adherence hemagglutination. This case was also considered to be presumptively caused by HAV. In addition, we studied anti-HAV in patients with chronic active hepatitis. The incidence of anti-HAV in 13 HBsAg-positive cases was 31%, which did not differ from the 32% found in 22 HBsAg-negative cases. There was one seroconversion for anti-HAV in 1 patient with HBsAg-negative chronic active hepatitis, but this appeared to be an epiphenomenon. We looked for fecal shedding of HAV in 14 patients with HBsAg-negative chronic active hepatitis without success.

Original languageEnglish (US)
Pages (from-to)879-882
Number of pages4
JournalGastroenterology
Volume74
Issue number5 PART 1
StatePublished - 1978
Externally publishedYes

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Hepatitis Viruses
Virus Diseases
Chronic Hepatitis
Hepatitis B Surface Antigens
Hepatitis
Hepatitis A virus
Antibodies
Hemagglutination
Electron Microscopy
Radioimmunoassay
Survivors
Hepatitis A Antibodies
Proxy
Incidence

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Rakela, J., Redeker, A. G., Edwards, V. M., Decker, R., Overby, L. R., & Mosley, J. W. (1978). Hepatitis a virus infection in fulminant hepatitis and chronic active hepatitis. Gastroenterology, 74(5 PART 1), 879-882.

Hepatitis a virus infection in fulminant hepatitis and chronic active hepatitis. / Rakela, Jorge; Redeker, Allan G.; Edwards, Virginia M.; Decker, Richard; Overby, Lacy R.; Mosley, James W.

In: Gastroenterology, Vol. 74, No. 5 PART 1, 1978, p. 879-882.

Research output: Contribution to journalArticle

Rakela, J, Redeker, AG, Edwards, VM, Decker, R, Overby, LR & Mosley, JW 1978, 'Hepatitis a virus infection in fulminant hepatitis and chronic active hepatitis', Gastroenterology, vol. 74, no. 5 PART 1, pp. 879-882.
Rakela J, Redeker AG, Edwards VM, Decker R, Overby LR, Mosley JW. Hepatitis a virus infection in fulminant hepatitis and chronic active hepatitis. Gastroenterology. 1978;74(5 PART 1):879-882.
Rakela, Jorge ; Redeker, Allan G. ; Edwards, Virginia M. ; Decker, Richard ; Overby, Lacy R. ; Mosley, James W. / Hepatitis a virus infection in fulminant hepatitis and chronic active hepatitis. In: Gastroenterology. 1978 ; Vol. 74, No. 5 PART 1. pp. 879-882.
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