Hepatic steatosis: Correlations of body mass index, CT fat measurements, and liver density with biopsy results

Ron C. Gaba, Grace Knuttinen, Tamara R. Brodsky, Sarah Palestrant, Benedictta O. Omene, Charles A. Owens, James T. Bui

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

PURPOSE To assess the relationship between body mass index (BMI), subcutaneous and intra-abdominal fat, liver density, and histopathologic hepatic steatosis. MATERIALS AND METHODS In this retrospective study, 143 patients (male/female, 67/76; mean age, 50 years) underwent a non-targeted transjugular (n=125) or percutaneous (n=18) liver biopsy between 2006 and 2010. The biopsy indications included chronic liver parenchymal disease staging (n=88), elevated enzymes (n=39), or other reasons (n=16). The BMI and non-contrast liver computed tomography liver density were recorded for each patient. The thicknesses of the anterior, posterior, and posterolateral subcutaneous fat, along with the intra-abdominal fat, were measured. The values were then correlated with histopathologic steatosis. RESULTS Of the patients, 47/143 (32%), 39/143 (28%), and 57/143 (40%) were normal weight, overweight, and obese, respectively. Steatosis was present in 13/47 (28%) of normal weight, 18/39 (46%) of overweight, and 38/57 (67%) of obese patients. Significant differences in BMI (26.7 kg/m 2 vs. 31.7 kg/ m 2 vs. 35.0 kg/m 2, P < 0.001), liver density (52.8 HU vs. 54.4 HU vs. 42.0 HU, P < 0.001), anterior subcutaneous (1.8 cm vs. 2.4 cm vs. 2.9 cm, P < 0.001), posterolateral subcutaneous (2.8 cm vs. 3.2 cm vs. 4.4 cm, P < 0.004), posterior subcutaneous (1.9 cm vs. 2.5 cm vs. 3.4 cm, P < 0.001), and intra-abdominal fat thickness (1.1 cm vs. 1.3 cm vs. 1.4 cm, P < 0.013) were identified in patients with different degrees of steatosis (none, minimal to mild, moderate to severe, respectively). BMI (r=0.37, P < 0.001) and the anterior subcutaneous fat (r=0.30, P < 0.001) had a moderate correlation with the presence of liver steatosis. A combination of a BMI ≥32.0 kg/ m 2 and an anterior subcutaneous fat thickness ≥2.4 cm had a 40% sensitivity and 90% specificity for the identification of steatosis. CONCLUSION Increase in the anthropomorphic metrics of obesity is associated with an increased frequency of liver steatosis.

Original languageEnglish (US)
Pages (from-to)282-287
Number of pages6
JournalDiagnostic and Interventional Radiology
Volume18
Issue number3
DOIs
StatePublished - May 1 2012
Externally publishedYes

Fingerprint

Body Mass Index
Fats
Biopsy
Intra-Abdominal Fat
Subcutaneous Fat
Liver
Fatty Liver
Weights and Measures
Liver Diseases
Retrospective Studies
Obesity
Tomography
Sensitivity and Specificity
Enzymes

Keywords

  • Biopsy
  • Body mass index
  • Fatty liver
  • X-ray computed tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Hepatic steatosis : Correlations of body mass index, CT fat measurements, and liver density with biopsy results. / Gaba, Ron C.; Knuttinen, Grace; Brodsky, Tamara R.; Palestrant, Sarah; Omene, Benedictta O.; Owens, Charles A.; Bui, James T.

In: Diagnostic and Interventional Radiology, Vol. 18, No. 3, 01.05.2012, p. 282-287.

Research output: Contribution to journalArticle

Gaba, Ron C. ; Knuttinen, Grace ; Brodsky, Tamara R. ; Palestrant, Sarah ; Omene, Benedictta O. ; Owens, Charles A. ; Bui, James T. / Hepatic steatosis : Correlations of body mass index, CT fat measurements, and liver density with biopsy results. In: Diagnostic and Interventional Radiology. 2012 ; Vol. 18, No. 3. pp. 282-287.
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abstract = "PURPOSE To assess the relationship between body mass index (BMI), subcutaneous and intra-abdominal fat, liver density, and histopathologic hepatic steatosis. MATERIALS AND METHODS In this retrospective study, 143 patients (male/female, 67/76; mean age, 50 years) underwent a non-targeted transjugular (n=125) or percutaneous (n=18) liver biopsy between 2006 and 2010. The biopsy indications included chronic liver parenchymal disease staging (n=88), elevated enzymes (n=39), or other reasons (n=16). The BMI and non-contrast liver computed tomography liver density were recorded for each patient. The thicknesses of the anterior, posterior, and posterolateral subcutaneous fat, along with the intra-abdominal fat, were measured. The values were then correlated with histopathologic steatosis. RESULTS Of the patients, 47/143 (32{\%}), 39/143 (28{\%}), and 57/143 (40{\%}) were normal weight, overweight, and obese, respectively. Steatosis was present in 13/47 (28{\%}) of normal weight, 18/39 (46{\%}) of overweight, and 38/57 (67{\%}) of obese patients. Significant differences in BMI (26.7 kg/m 2 vs. 31.7 kg/ m 2 vs. 35.0 kg/m 2, P < 0.001), liver density (52.8 HU vs. 54.4 HU vs. 42.0 HU, P < 0.001), anterior subcutaneous (1.8 cm vs. 2.4 cm vs. 2.9 cm, P < 0.001), posterolateral subcutaneous (2.8 cm vs. 3.2 cm vs. 4.4 cm, P < 0.004), posterior subcutaneous (1.9 cm vs. 2.5 cm vs. 3.4 cm, P < 0.001), and intra-abdominal fat thickness (1.1 cm vs. 1.3 cm vs. 1.4 cm, P < 0.013) were identified in patients with different degrees of steatosis (none, minimal to mild, moderate to severe, respectively). BMI (r=0.37, P < 0.001) and the anterior subcutaneous fat (r=0.30, P < 0.001) had a moderate correlation with the presence of liver steatosis. A combination of a BMI ≥32.0 kg/ m 2 and an anterior subcutaneous fat thickness ≥2.4 cm had a 40{\%} sensitivity and 90{\%} specificity for the identification of steatosis. CONCLUSION Increase in the anthropomorphic metrics of obesity is associated with an increased frequency of liver steatosis.",
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AU - Gaba, Ron C.

AU - Knuttinen, Grace

AU - Brodsky, Tamara R.

AU - Palestrant, Sarah

AU - Omene, Benedictta O.

AU - Owens, Charles A.

AU - Bui, James T.

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N2 - PURPOSE To assess the relationship between body mass index (BMI), subcutaneous and intra-abdominal fat, liver density, and histopathologic hepatic steatosis. MATERIALS AND METHODS In this retrospective study, 143 patients (male/female, 67/76; mean age, 50 years) underwent a non-targeted transjugular (n=125) or percutaneous (n=18) liver biopsy between 2006 and 2010. The biopsy indications included chronic liver parenchymal disease staging (n=88), elevated enzymes (n=39), or other reasons (n=16). The BMI and non-contrast liver computed tomography liver density were recorded for each patient. The thicknesses of the anterior, posterior, and posterolateral subcutaneous fat, along with the intra-abdominal fat, were measured. The values were then correlated with histopathologic steatosis. RESULTS Of the patients, 47/143 (32%), 39/143 (28%), and 57/143 (40%) were normal weight, overweight, and obese, respectively. Steatosis was present in 13/47 (28%) of normal weight, 18/39 (46%) of overweight, and 38/57 (67%) of obese patients. Significant differences in BMI (26.7 kg/m 2 vs. 31.7 kg/ m 2 vs. 35.0 kg/m 2, P < 0.001), liver density (52.8 HU vs. 54.4 HU vs. 42.0 HU, P < 0.001), anterior subcutaneous (1.8 cm vs. 2.4 cm vs. 2.9 cm, P < 0.001), posterolateral subcutaneous (2.8 cm vs. 3.2 cm vs. 4.4 cm, P < 0.004), posterior subcutaneous (1.9 cm vs. 2.5 cm vs. 3.4 cm, P < 0.001), and intra-abdominal fat thickness (1.1 cm vs. 1.3 cm vs. 1.4 cm, P < 0.013) were identified in patients with different degrees of steatosis (none, minimal to mild, moderate to severe, respectively). BMI (r=0.37, P < 0.001) and the anterior subcutaneous fat (r=0.30, P < 0.001) had a moderate correlation with the presence of liver steatosis. A combination of a BMI ≥32.0 kg/ m 2 and an anterior subcutaneous fat thickness ≥2.4 cm had a 40% sensitivity and 90% specificity for the identification of steatosis. CONCLUSION Increase in the anthropomorphic metrics of obesity is associated with an increased frequency of liver steatosis.

AB - PURPOSE To assess the relationship between body mass index (BMI), subcutaneous and intra-abdominal fat, liver density, and histopathologic hepatic steatosis. MATERIALS AND METHODS In this retrospective study, 143 patients (male/female, 67/76; mean age, 50 years) underwent a non-targeted transjugular (n=125) or percutaneous (n=18) liver biopsy between 2006 and 2010. The biopsy indications included chronic liver parenchymal disease staging (n=88), elevated enzymes (n=39), or other reasons (n=16). The BMI and non-contrast liver computed tomography liver density were recorded for each patient. The thicknesses of the anterior, posterior, and posterolateral subcutaneous fat, along with the intra-abdominal fat, were measured. The values were then correlated with histopathologic steatosis. RESULTS Of the patients, 47/143 (32%), 39/143 (28%), and 57/143 (40%) were normal weight, overweight, and obese, respectively. Steatosis was present in 13/47 (28%) of normal weight, 18/39 (46%) of overweight, and 38/57 (67%) of obese patients. Significant differences in BMI (26.7 kg/m 2 vs. 31.7 kg/ m 2 vs. 35.0 kg/m 2, P < 0.001), liver density (52.8 HU vs. 54.4 HU vs. 42.0 HU, P < 0.001), anterior subcutaneous (1.8 cm vs. 2.4 cm vs. 2.9 cm, P < 0.001), posterolateral subcutaneous (2.8 cm vs. 3.2 cm vs. 4.4 cm, P < 0.004), posterior subcutaneous (1.9 cm vs. 2.5 cm vs. 3.4 cm, P < 0.001), and intra-abdominal fat thickness (1.1 cm vs. 1.3 cm vs. 1.4 cm, P < 0.013) were identified in patients with different degrees of steatosis (none, minimal to mild, moderate to severe, respectively). BMI (r=0.37, P < 0.001) and the anterior subcutaneous fat (r=0.30, P < 0.001) had a moderate correlation with the presence of liver steatosis. A combination of a BMI ≥32.0 kg/ m 2 and an anterior subcutaneous fat thickness ≥2.4 cm had a 40% sensitivity and 90% specificity for the identification of steatosis. CONCLUSION Increase in the anthropomorphic metrics of obesity is associated with an increased frequency of liver steatosis.

KW - Biopsy

KW - Body mass index

KW - Fatty liver

KW - X-ray computed tomography

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