Hepatic sinusoidal endothelial cells

Moira B. Hilscher; Robert C. Huebert; Vijay H. Shah

doi:10.1002/9781118663387.ch5

Hepatic sinusoidal endothelial cells

Moira B. Hilscher, Robert C. Huebert, Vijay H. Shah

Gastroenterology and Hepatology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

This chapter addresses the structure and function of hepatic sinusoidal endothelial cells and their role in various disease states. Hepatic sinusoidal endothelial cells have a phenotype which is distinctive from other endothelial cells, notably due to the presence of fenestrae and the lack of a basement membrane. These features permit active roles in endocytosis, antigen presentation, and regulation of liver hemodynamics. Injury instigates loss of this specialized phenotype and contributes to the pathogenesis of multiple disease states, including cirrhosis and portal hypertension. Hepatic sinusoidal endothelial cells have also been implicated in liver regeneration, fibrogenesis, and pathological angiogenesis.

Original language	English (US)
Title of host publication	Signaling Pathways in Liver Diseases
Subtitle of host publication	Third Edition
Publisher	Wiley-Blackwell
Pages	73-84
Number of pages	12
ISBN (Electronic)	9781118663387
ISBN (Print)	9781118663394
DOIs	https://doi.org/10.1002/9781118663387.ch5
State	Published - Sep 28 2015

Keywords

Angiogenesis
Bone marrow-derived endothelial progenitor cells
Capillarization
Endocytosis
Endothelial nitric oxide synthetase
Fenestrae
Fibrosis
Hepatic sinusoidal endothelial cell
Pseudocapillarization
Regeneration

ASJC Scopus subject areas

General Medicine

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10.1002/9781118663387.ch5

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title = "Hepatic sinusoidal endothelial cells",

abstract = "This chapter addresses the structure and function of hepatic sinusoidal endothelial cells and their role in various disease states. Hepatic sinusoidal endothelial cells have a phenotype which is distinctive from other endothelial cells, notably due to the presence of fenestrae and the lack of a basement membrane. These features permit active roles in endocytosis, antigen presentation, and regulation of liver hemodynamics. Injury instigates loss of this specialized phenotype and contributes to the pathogenesis of multiple disease states, including cirrhosis and portal hypertension. Hepatic sinusoidal endothelial cells have also been implicated in liver regeneration, fibrogenesis, and pathological angiogenesis.",

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AU - Hilscher, Moira B.

AU - Huebert, Robert C.

AU - Shah, Vijay H.

PY - 2015/9/28

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N2 - This chapter addresses the structure and function of hepatic sinusoidal endothelial cells and their role in various disease states. Hepatic sinusoidal endothelial cells have a phenotype which is distinctive from other endothelial cells, notably due to the presence of fenestrae and the lack of a basement membrane. These features permit active roles in endocytosis, antigen presentation, and regulation of liver hemodynamics. Injury instigates loss of this specialized phenotype and contributes to the pathogenesis of multiple disease states, including cirrhosis and portal hypertension. Hepatic sinusoidal endothelial cells have also been implicated in liver regeneration, fibrogenesis, and pathological angiogenesis.

AB - This chapter addresses the structure and function of hepatic sinusoidal endothelial cells and their role in various disease states. Hepatic sinusoidal endothelial cells have a phenotype which is distinctive from other endothelial cells, notably due to the presence of fenestrae and the lack of a basement membrane. These features permit active roles in endocytosis, antigen presentation, and regulation of liver hemodynamics. Injury instigates loss of this specialized phenotype and contributes to the pathogenesis of multiple disease states, including cirrhosis and portal hypertension. Hepatic sinusoidal endothelial cells have also been implicated in liver regeneration, fibrogenesis, and pathological angiogenesis.

KW - Angiogenesis

KW - Bone marrow-derived endothelial progenitor cells

KW - Capillarization

KW - Endocytosis

KW - Endothelial nitric oxide synthetase

KW - Fenestrae

KW - Fibrosis

KW - Hepatic sinusoidal endothelial cell

KW - Pseudocapillarization

KW - Regeneration

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BT - Signaling Pathways in Liver Diseases

PB - Wiley-Blackwell

ER -

Hepatic sinusoidal endothelial cells

Abstract

Keywords

ASJC Scopus subject areas

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