TY - JOUR
T1 - Hepatic resection for huge (>15 cm) multinodular HCC with macrovascular invasion
AU - Huang, Jiwei
AU - Hernandez-Alejandro, Roberto
AU - Croome, Kristopher P.
AU - Zeng, Yong
AU - Wu, Hong
AU - Chen, Zheyu
PY - 2012/12
Y1 - 2012/12
N2 - Background: Surgical resection has routinely not been recommended for patients with huge (>15 cm) multinodular lesions and macrovascular invasion (advanced-stage hepatocellular carcinoma [HCC] patients) because of high operative mortality, recurrence rate, and lack of survival benefit. Methods: A retrospective study of 1425 patients was carried out, of which 1245 patients met EASL/AASLD criteria for hepatic resection (HR-EA group), 116 were surgically treated advanced-stage HCC patients (HR-AS group), and 64 were advanced-stage HCC patients receiving nonsurgical treatments (N-AS group). Conclusion: HR may still be suitable for the HCC patients with huge (>15 cm) multinodular lesions and macrovascular invasion in selected cases. Advanced-stage HCC patients without liver cirrhosis and with a tumor-free resection margin could enjoy longer survival and lower recurrence. Preoperative and/or postoperative TACE provides no survival benefits for advanced-stage HCC patients.
AB - Background: Surgical resection has routinely not been recommended for patients with huge (>15 cm) multinodular lesions and macrovascular invasion (advanced-stage hepatocellular carcinoma [HCC] patients) because of high operative mortality, recurrence rate, and lack of survival benefit. Methods: A retrospective study of 1425 patients was carried out, of which 1245 patients met EASL/AASLD criteria for hepatic resection (HR-EA group), 116 were surgically treated advanced-stage HCC patients (HR-AS group), and 64 were advanced-stage HCC patients receiving nonsurgical treatments (N-AS group). Conclusion: HR may still be suitable for the HCC patients with huge (>15 cm) multinodular lesions and macrovascular invasion in selected cases. Advanced-stage HCC patients without liver cirrhosis and with a tumor-free resection margin could enjoy longer survival and lower recurrence. Preoperative and/or postoperative TACE provides no survival benefits for advanced-stage HCC patients.
KW - Hepatectomy
KW - Hepatocellular carcinoma
KW - Liver cirrhosis
KW - Recurrence
KW - Survival
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U2 - 10.1016/j.jss.2012.04.058
DO - 10.1016/j.jss.2012.04.058
M3 - Article
C2 - 22656039
AN - SCOPUS:84869087488
SN - 0022-4804
VL - 178
SP - 743
EP - 750
JO - Journal of Surgical Research
JF - Journal of Surgical Research
IS - 2
ER -