Hepatic resection for huge (>15 cm) multinodular HCC with macrovascular invasion

Jiwei Huang, Roberto Hernandez-Alejandro, Kristopher P. Croome, Yong Zeng, Hong Wu, Zheyu Chen

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Background: Surgical resection has routinely not been recommended for patients with huge (>15 cm) multinodular lesions and macrovascular invasion (advanced-stage hepatocellular carcinoma [HCC] patients) because of high operative mortality, recurrence rate, and lack of survival benefit. Methods: A retrospective study of 1425 patients was carried out, of which 1245 patients met EASL/AASLD criteria for hepatic resection (HR-EA group), 116 were surgically treated advanced-stage HCC patients (HR-AS group), and 64 were advanced-stage HCC patients receiving nonsurgical treatments (N-AS group). Conclusion: HR may still be suitable for the HCC patients with huge (>15 cm) multinodular lesions and macrovascular invasion in selected cases. Advanced-stage HCC patients without liver cirrhosis and with a tumor-free resection margin could enjoy longer survival and lower recurrence. Preoperative and/or postoperative TACE provides no survival benefits for advanced-stage HCC patients.

Original languageEnglish (US)
Pages (from-to)743-750
Number of pages8
JournalJournal of Surgical Research
Volume178
Issue number2
DOIs
StatePublished - Dec 2012

Keywords

  • Hepatectomy
  • Hepatocellular carcinoma
  • Liver cirrhosis
  • Recurrence
  • Survival

ASJC Scopus subject areas

  • Surgery

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