Hepatic resection for huge (>15 cm) multinodular HCC with macrovascular invasion

Jiwei Huang, Roberto Hernandez-Alejandro, Kristopher P. Croome, Yong Zeng, Hong Wu, Zheyu Chen

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Surgical resection has routinely not been recommended for patients with huge (>15 cm) multinodular lesions and macrovascular invasion (advanced-stage hepatocellular carcinoma [HCC] patients) because of high operative mortality, recurrence rate, and lack of survival benefit. Methods: A retrospective study of 1425 patients was carried out, of which 1245 patients met EASL/AASLD criteria for hepatic resection (HR-EA group), 116 were surgically treated advanced-stage HCC patients (HR-AS group), and 64 were advanced-stage HCC patients receiving nonsurgical treatments (N-AS group). Conclusion: HR may still be suitable for the HCC patients with huge (>15 cm) multinodular lesions and macrovascular invasion in selected cases. Advanced-stage HCC patients without liver cirrhosis and with a tumor-free resection margin could enjoy longer survival and lower recurrence. Preoperative and/or postoperative TACE provides no survival benefits for advanced-stage HCC patients.

Original languageEnglish (US)
Pages (from-to)743-750
Number of pages8
JournalJournal of Surgical Research
Volume178
Issue number2
DOIs
StatePublished - Dec 2012
Externally publishedYes

Fingerprint

Hepatocellular Carcinoma
Liver
Survival
Recurrence
Liver Cirrhosis
Retrospective Studies
Mortality

Keywords

  • Hepatectomy
  • Hepatocellular carcinoma
  • Liver cirrhosis
  • Recurrence
  • Survival

ASJC Scopus subject areas

  • Surgery

Cite this

Huang, J., Hernandez-Alejandro, R., Croome, K. P., Zeng, Y., Wu, H., & Chen, Z. (2012). Hepatic resection for huge (>15 cm) multinodular HCC with macrovascular invasion. Journal of Surgical Research, 178(2), 743-750. https://doi.org/10.1016/j.jss.2012.04.058

Hepatic resection for huge (>15 cm) multinodular HCC with macrovascular invasion. / Huang, Jiwei; Hernandez-Alejandro, Roberto; Croome, Kristopher P.; Zeng, Yong; Wu, Hong; Chen, Zheyu.

In: Journal of Surgical Research, Vol. 178, No. 2, 12.2012, p. 743-750.

Research output: Contribution to journalArticle

Huang, J, Hernandez-Alejandro, R, Croome, KP, Zeng, Y, Wu, H & Chen, Z 2012, 'Hepatic resection for huge (>15 cm) multinodular HCC with macrovascular invasion', Journal of Surgical Research, vol. 178, no. 2, pp. 743-750. https://doi.org/10.1016/j.jss.2012.04.058
Huang, Jiwei ; Hernandez-Alejandro, Roberto ; Croome, Kristopher P. ; Zeng, Yong ; Wu, Hong ; Chen, Zheyu. / Hepatic resection for huge (>15 cm) multinodular HCC with macrovascular invasion. In: Journal of Surgical Research. 2012 ; Vol. 178, No. 2. pp. 743-750.
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abstract = "Background: Surgical resection has routinely not been recommended for patients with huge (>15 cm) multinodular lesions and macrovascular invasion (advanced-stage hepatocellular carcinoma [HCC] patients) because of high operative mortality, recurrence rate, and lack of survival benefit. Methods: A retrospective study of 1425 patients was carried out, of which 1245 patients met EASL/AASLD criteria for hepatic resection (HR-EA group), 116 were surgically treated advanced-stage HCC patients (HR-AS group), and 64 were advanced-stage HCC patients receiving nonsurgical treatments (N-AS group). Conclusion: HR may still be suitable for the HCC patients with huge (>15 cm) multinodular lesions and macrovascular invasion in selected cases. Advanced-stage HCC patients without liver cirrhosis and with a tumor-free resection margin could enjoy longer survival and lower recurrence. Preoperative and/or postoperative TACE provides no survival benefits for advanced-stage HCC patients.",
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