Hepatic perihilar amphicrine cholangiocarcinoma

A case report

Thomas W. Czeczok, David J. Schembri-Wismayer, Thomas Christopher Smyrk, Mark Truty, Taofic Mounajjed

Research output: Contribution to journalArticle

Abstract

Mixed neuroendocrine nonneuroendocrine neoplasms (MiNEN) are tumors composed of adenocarcinoma and neuroendocrine neoplasm and include collision, combined, and amphicrine. Within the hepatobiliary tree, tumors of this histologic type are extremely rare, particularly the amphicrine type. In this case study, we describe a 63-year-old man with a hepatic hilar amphicrine tumor. An initial diagnosis of neuroendocrine tumor was made based on biopsy (chromogranin and synaptophysin positivity). On resection, the tumor contained histologic features of both adenocarcinoma and neuroendocrine carcinoma. Immunohistochemically, all tumor cells expressed both chromogranin and synaptophysin, keratin 7, and Cam5.2. Mucin production was evident in both components demonstrated by mucicarmine stain. Albumin RNA in situ hybridization (ISH) was positive, supporting hepatic source. The tumor is classified as an amphicrine carcinoma given the dual expression of both adenocarcinoma and neuroendocrine markers in both components. This is the first amphicrine carcinoma of the hepatic hilum reported in the literature.

Original languageEnglish (US)
Pages (from-to)60-63
Number of pages4
JournalHuman Pathology: Case Reports
Volume13
DOIs
StatePublished - Sep 1 2018

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Klatskin Tumor
Liver
Neoplasms
Chromogranins
Synaptophysin
Adenocarcinoma
Keratin-7
Carcinoma
Neuroendocrine Carcinoma
Neuroendocrine Tumors
Mucins
In Situ Hybridization
Albumins
Coloring Agents
RNA
Biopsy

Keywords

  • Cholangiocarcinoma
  • Hepatobiliary
  • Immunohistochemistry
  • Liver
  • Mixed neuroendocrine-nonneuroendocrine carcinoma
  • Neuroendocrine tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Hepatic perihilar amphicrine cholangiocarcinoma : A case report. / Czeczok, Thomas W.; Schembri-Wismayer, David J.; Smyrk, Thomas Christopher; Truty, Mark; Mounajjed, Taofic.

In: Human Pathology: Case Reports, Vol. 13, 01.09.2018, p. 60-63.

Research output: Contribution to journalArticle

Czeczok, Thomas W. ; Schembri-Wismayer, David J. ; Smyrk, Thomas Christopher ; Truty, Mark ; Mounajjed, Taofic. / Hepatic perihilar amphicrine cholangiocarcinoma : A case report. In: Human Pathology: Case Reports. 2018 ; Vol. 13. pp. 60-63.
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