Hepatic Cyst Infection in Autosomal Dominant Polycystic Kidney Disease

AMALIO TELENTI, VICENTE E. TORRES, JOHN B. GROSS, ROBERT E. VAN SCOY, MANUEL L. BROWN, ROBERT R. HATTERY

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Abstract

To characterize the syndrome of hepatic cyst infection in autosomal dominant polycystic kidney disease (ADPKD) and to review its diagnosis and management, we retrospectively studied five such cases in patients from our institution and nine detailed case reports from the literature. The clinical manifestations were an acute (58%) or subacute (42%) febrile illness, typically associated with tenderness in the right upper quadrant, leukocytosis, a very high erythrocyte sedimentation rate, but minor abnormalities of liver function tests. Bacteremia was present in 7 of 11 patients. Enterobacteriaceae grew in pure culture from the cyst fluid in 9 of 12 patients. Complex cysts were observed by ultrasonography (in four of eight patients), computed tomography (in six of nine), and magnetic resonance imaging (in two of two). 111In leukocyte scans were positive in all four patients in whom they were done, and 67Ga scans were positive in only one of three patients. An unfavorable outcome was observed in six of seven patients treated with only antibiotics, in contrast with one of seven patients who received antibiotics and early drainage. In two patients, ciprofloxacin cyst levels were 2.3 and 4.8 times higher than the level in serum; in a third patient, cyst levels remained in therapeutic range 30 hours after the last dose of ciprofloxacin, at which time serum levels were undetectable. Clinical and laboratory features and the use of modern scanning techniques facilitate a prompt diagnosis of infection in hepatic cysts in ADPKD. The treatment of choice is a combination of percutaneous drainage and antimicrobial therapy.

Original languageEnglish (US)
Pages (from-to)933-942
Number of pages10
JournalMayo Clinic proceedings
Volume65
Issue number7
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Medicine(all)

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    TELENTI, AMALIO., TORRES, VICENTE. E., GROSS, JOHN. B., VAN SCOY, ROBERT. E., BROWN, MANUEL. L., & HATTERY, ROBERT. R. (1990). Hepatic Cyst Infection in Autosomal Dominant Polycystic Kidney Disease. Mayo Clinic proceedings, 65(7), 933-942. https://doi.org/10.1016/S0025-6196(12)65154-4