Hepatic arterial changes following iodized oil chemoembolization of hepatocellular carcinoma

Incidence and technical consequence

Ron C. Gaba, Tamara R. Brodsky, Grace Knuttinen, Benedictta O. Omene, Charles A. Owens, James T. Bui

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To describe the nature, incidence, and therapeutic consequence of hepatic arterial changes seen following transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). Methods: In this retrospective study, 46 patients with HCC underwent ≥ 2 TACE treatment sessions between 2004 and 2010. All patients had hepatic angiography on days of treatment. Sequential angiographic studies were reviewed to assess for abnormalities in appearance of the hepatic vasculature. Angiographic abnormalities were graded in a binary fashion: present or absent. When present, abnormalities and effect on drug delivery were recorded. Results: 123 (mean 2.7, range 2-5) successful lobar (n = 34), segmental (n = 88), or superselective (n = 1) TACE procedures were performed in 46 patients (M:F = 36:10, mean age 59 years). TACE was performed using 1:1 chemotherapy to iodized oil mixture without (n = 102) or with (n = 21) particle embolization. An abnormal angiographic appearance was identified in 21/46 (38%) patients and in 23/123 (19%) procedures, with first appearance after mean 1.5 (range 1-3) TACE sessions and mean 176 (range 27-509) days after initial TACE. Abnormalities included new vessel attenuation or stenosis (n = 10, 43%), slow flow (n = 2, 9%), and new vascular occlusions (n = 11, 48%). These vascular changes did not result in inability to perform repeat TACE in 16/16 (100%) cases where vascular changes were present and TACE was repeated to the same liver lobe. Conclusion: While the hepatic vasculature is altered in many patients undergoing TACE, arterial abnormalities did not preclude therapy.Further investigation is warranted.

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalArtery Research
Volume6
Issue number1
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

Fingerprint

Ethiodized Oil
Hepatocellular Carcinoma
Liver
Incidence
Blood Vessels
Therapeutics
Angiography
Pathologic Constriction
Retrospective Studies
Drug Therapy
Pharmaceutical Preparations

Keywords

  • Chemoembolization
  • Hepatic artery
  • Hepatocellular carcinoma
  • Iodized oil

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anatomy
  • Physiology (medical)

Cite this

Hepatic arterial changes following iodized oil chemoembolization of hepatocellular carcinoma : Incidence and technical consequence. / Gaba, Ron C.; Brodsky, Tamara R.; Knuttinen, Grace; Omene, Benedictta O.; Owens, Charles A.; Bui, James T.

In: Artery Research, Vol. 6, No. 1, 01.03.2012, p. 21-27.

Research output: Contribution to journalArticle

Gaba, Ron C. ; Brodsky, Tamara R. ; Knuttinen, Grace ; Omene, Benedictta O. ; Owens, Charles A. ; Bui, James T. / Hepatic arterial changes following iodized oil chemoembolization of hepatocellular carcinoma : Incidence and technical consequence. In: Artery Research. 2012 ; Vol. 6, No. 1. pp. 21-27.
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abstract = "Objective: To describe the nature, incidence, and therapeutic consequence of hepatic arterial changes seen following transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). Methods: In this retrospective study, 46 patients with HCC underwent ≥ 2 TACE treatment sessions between 2004 and 2010. All patients had hepatic angiography on days of treatment. Sequential angiographic studies were reviewed to assess for abnormalities in appearance of the hepatic vasculature. Angiographic abnormalities were graded in a binary fashion: present or absent. When present, abnormalities and effect on drug delivery were recorded. Results: 123 (mean 2.7, range 2-5) successful lobar (n = 34), segmental (n = 88), or superselective (n = 1) TACE procedures were performed in 46 patients (M:F = 36:10, mean age 59 years). TACE was performed using 1:1 chemotherapy to iodized oil mixture without (n = 102) or with (n = 21) particle embolization. An abnormal angiographic appearance was identified in 21/46 (38{\%}) patients and in 23/123 (19{\%}) procedures, with first appearance after mean 1.5 (range 1-3) TACE sessions and mean 176 (range 27-509) days after initial TACE. Abnormalities included new vessel attenuation or stenosis (n = 10, 43{\%}), slow flow (n = 2, 9{\%}), and new vascular occlusions (n = 11, 48{\%}). These vascular changes did not result in inability to perform repeat TACE in 16/16 (100{\%}) cases where vascular changes were present and TACE was repeated to the same liver lobe. Conclusion: While the hepatic vasculature is altered in many patients undergoing TACE, arterial abnormalities did not preclude therapy.Further investigation is warranted.",
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T2 - Incidence and technical consequence

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AU - Omene, Benedictta O.

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AB - Objective: To describe the nature, incidence, and therapeutic consequence of hepatic arterial changes seen following transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC). Methods: In this retrospective study, 46 patients with HCC underwent ≥ 2 TACE treatment sessions between 2004 and 2010. All patients had hepatic angiography on days of treatment. Sequential angiographic studies were reviewed to assess for abnormalities in appearance of the hepatic vasculature. Angiographic abnormalities were graded in a binary fashion: present or absent. When present, abnormalities and effect on drug delivery were recorded. Results: 123 (mean 2.7, range 2-5) successful lobar (n = 34), segmental (n = 88), or superselective (n = 1) TACE procedures were performed in 46 patients (M:F = 36:10, mean age 59 years). TACE was performed using 1:1 chemotherapy to iodized oil mixture without (n = 102) or with (n = 21) particle embolization. An abnormal angiographic appearance was identified in 21/46 (38%) patients and in 23/123 (19%) procedures, with first appearance after mean 1.5 (range 1-3) TACE sessions and mean 176 (range 27-509) days after initial TACE. Abnormalities included new vessel attenuation or stenosis (n = 10, 43%), slow flow (n = 2, 9%), and new vascular occlusions (n = 11, 48%). These vascular changes did not result in inability to perform repeat TACE in 16/16 (100%) cases where vascular changes were present and TACE was repeated to the same liver lobe. Conclusion: While the hepatic vasculature is altered in many patients undergoing TACE, arterial abnormalities did not preclude therapy.Further investigation is warranted.

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KW - Hepatic artery

KW - Hepatocellular carcinoma

KW - Iodized oil

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