Heme oxygenase-1 and acute kidney injury

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Heme oxygenase activity, possessed by an inducible heme oxygenase-1 (HO-1) and a constitutive isoform (HO-2), catalyzes the conversion of heme to biliverdin, liberates iron, and generates carbon monoxide. First shown in acute kidney injury (AKI), HO-1 is now recognized as a protectant against diverse insults in assorted tissues. This review summarizes recent contributions to the field of HO-1 and AKI. RECENT FINDINGS: Recent findings elucidate the following: the transcriptional regulation and significance of human HO-1 in AKI; the protective effects of HO-1 in age-dependent and sepsis-related AKI, cardiorenal syndromes, and acute vascular rejection in renal xenografts; the role of heme oxygenase in tubuloglomerular feedback and renal resistance to injury; the basis for cytoprotection by HO-1; the protective properties of ferritin and carbon monoxide; HO-1 and the AKI-chronic kidney disease transition; HO-1 as a biomarker in AKI; the role of HO-1 in mediating the protective effects of specific cytokines, stem cells, and therapeutic agents in AKI; and HO-2 as a protectant in AKI. SUMMARY: Recent contributions support, and elucidate the basis for, the induction of HO-1 as a protectant against AKI. Translating such therapeutic potential into a therapeutic reality requires well tolerated and effective modalities for upregulating HO-1 and/or administering its products, which, optimally, should be salutary even when AKI is already established.

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalCurrent Opinion in Nephrology and Hypertension
Volume23
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Heme Oxygenase-1
Acute Kidney Injury
Heme Oxygenase (Decyclizing)
Carbon Monoxide
Cardio-Renal Syndrome
Biliverdine
Kidney
Cytoprotection
Ferritins
Heme
Chronic Renal Insufficiency
Heterografts
Blood Vessels
Sepsis
Protein Isoforms
Stem Cells
Therapeutics
Iron
Biomarkers
Cytokines

Keywords

  • acute kidney injury
  • acute renal failure
  • cytoprotection
  • heme oxygenase-1

ASJC Scopus subject areas

  • Nephrology
  • Internal Medicine

Cite this

Heme oxygenase-1 and acute kidney injury. / Nath, Karl A.

In: Current Opinion in Nephrology and Hypertension, Vol. 23, No. 1, 01.2014, p. 17-24.

Research output: Contribution to journalArticle

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