Helicobacter pylori and dyspepsia: A population-based study of the organism and host

G. Richard Locke, Nicholas J. Talley, Daniel K. Nelson, K. Haruma, Amy L. Weaver, Alan R. Zinsmeister, L. Joseph Melton

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Abstract

OBJECTIVE: The role of Helicobacter pylori (HP) infection in dyspepsia in the absence of peptic ulcer remains controversial. Specific attributes of the organism or the host response may be important. We aimed to determine whether HP infection overall, CagA status, serum gastrin, or serum pepsinogen levels are associated with dyspepsia in the community. METHODS: A self-report bowel disease questionnaire was mailed to a random sample of Olmsted County, Minnesota residents, aged 20-50 yr. All respondents who reported symptoms of dyspepsia or irritable bowel syndrome (cases) and all respondents without significant GI symptoms (controls) were invited to participate (n = 260). They were each assessed by a physician and their medical records reviewed. Serum was obtained to measure HP and CagA antibodies, pepsinogen I and II levels, and basal serum gastrin using validated assays. RESULTS: Of the 148 (57%) subjects who agreed to participate, 36 had dyspepsia (17 had ulcer-like dyspepsia), 35 had irritable bowel syndrome (IBS) without dyspepsia, and 77 were asymptomatic. The proportion who were seropositive for HP were 17% in dyspepsia (24% in ulcer-like dyspepsia), 20% in IBS, and 12% in asymptomatic controls. HP was not associated with dyspepsia, ulcer-like dyspepsia, or IBS after adjusting for age. Pepsinogen levels and serum gastrin were not associated with any of the conditions studied. However, CagA antibody positivity was associated with IBS (p < 0.05), and a borderline statistically significant association with dyspepsia was detected (p = 0.08). CONCLUSIONS: In this community, HP infection overall does not seem to explain dyspepsia, although the role of CagA-positive HP strains deserve further study. (C) 2000 by Am. Coll. of Gastroenterology.

Original languageEnglish (US)
Pages (from-to)1906-1913
Number of pages8
JournalAmerican Journal of Gastroenterology
Volume95
Issue number8
DOIs
StatePublished - 2000

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Dyspepsia
Helicobacter pylori
Irritable Bowel Syndrome
Population
Pepsinogen A
Gastrins
Helicobacter Infections
Ulcer
Serum
Pepsinogen C
Antibodies
Gastroenterology
Peptic Ulcer
Self Report
Medical Records

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Richard Locke, G., Talley, N. J., Nelson, D. K., Haruma, K., Weaver, A. L., Zinsmeister, A. R., & Joseph Melton, L. (2000). Helicobacter pylori and dyspepsia: A population-based study of the organism and host. American Journal of Gastroenterology, 95(8), 1906-1913. https://doi.org/10.1016/S0002-9270(00)01043-1

Helicobacter pylori and dyspepsia : A population-based study of the organism and host. / Richard Locke, G.; Talley, Nicholas J.; Nelson, Daniel K.; Haruma, K.; Weaver, Amy L.; Zinsmeister, Alan R.; Joseph Melton, L.

In: American Journal of Gastroenterology, Vol. 95, No. 8, 2000, p. 1906-1913.

Research output: Contribution to journalArticle

Richard Locke, G, Talley, NJ, Nelson, DK, Haruma, K, Weaver, AL, Zinsmeister, AR & Joseph Melton, L 2000, 'Helicobacter pylori and dyspepsia: A population-based study of the organism and host', American Journal of Gastroenterology, vol. 95, no. 8, pp. 1906-1913. https://doi.org/10.1016/S0002-9270(00)01043-1
Richard Locke, G. ; Talley, Nicholas J. ; Nelson, Daniel K. ; Haruma, K. ; Weaver, Amy L. ; Zinsmeister, Alan R. ; Joseph Melton, L. / Helicobacter pylori and dyspepsia : A population-based study of the organism and host. In: American Journal of Gastroenterology. 2000 ; Vol. 95, No. 8. pp. 1906-1913.
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abstract = "OBJECTIVE: The role of Helicobacter pylori (HP) infection in dyspepsia in the absence of peptic ulcer remains controversial. Specific attributes of the organism or the host response may be important. We aimed to determine whether HP infection overall, CagA status, serum gastrin, or serum pepsinogen levels are associated with dyspepsia in the community. METHODS: A self-report bowel disease questionnaire was mailed to a random sample of Olmsted County, Minnesota residents, aged 20-50 yr. All respondents who reported symptoms of dyspepsia or irritable bowel syndrome (cases) and all respondents without significant GI symptoms (controls) were invited to participate (n = 260). They were each assessed by a physician and their medical records reviewed. Serum was obtained to measure HP and CagA antibodies, pepsinogen I and II levels, and basal serum gastrin using validated assays. RESULTS: Of the 148 (57{\%}) subjects who agreed to participate, 36 had dyspepsia (17 had ulcer-like dyspepsia), 35 had irritable bowel syndrome (IBS) without dyspepsia, and 77 were asymptomatic. The proportion who were seropositive for HP were 17{\%} in dyspepsia (24{\%} in ulcer-like dyspepsia), 20{\%} in IBS, and 12{\%} in asymptomatic controls. HP was not associated with dyspepsia, ulcer-like dyspepsia, or IBS after adjusting for age. Pepsinogen levels and serum gastrin were not associated with any of the conditions studied. However, CagA antibody positivity was associated with IBS (p < 0.05), and a borderline statistically significant association with dyspepsia was detected (p = 0.08). CONCLUSIONS: In this community, HP infection overall does not seem to explain dyspepsia, although the role of CagA-positive HP strains deserve further study. (C) 2000 by Am. Coll. of Gastroenterology.",
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T2 - A population-based study of the organism and host

AU - Richard Locke, G.

AU - Talley, Nicholas J.

AU - Nelson, Daniel K.

AU - Haruma, K.

AU - Weaver, Amy L.

AU - Zinsmeister, Alan R.

AU - Joseph Melton, L.

PY - 2000

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N2 - OBJECTIVE: The role of Helicobacter pylori (HP) infection in dyspepsia in the absence of peptic ulcer remains controversial. Specific attributes of the organism or the host response may be important. We aimed to determine whether HP infection overall, CagA status, serum gastrin, or serum pepsinogen levels are associated with dyspepsia in the community. METHODS: A self-report bowel disease questionnaire was mailed to a random sample of Olmsted County, Minnesota residents, aged 20-50 yr. All respondents who reported symptoms of dyspepsia or irritable bowel syndrome (cases) and all respondents without significant GI symptoms (controls) were invited to participate (n = 260). They were each assessed by a physician and their medical records reviewed. Serum was obtained to measure HP and CagA antibodies, pepsinogen I and II levels, and basal serum gastrin using validated assays. RESULTS: Of the 148 (57%) subjects who agreed to participate, 36 had dyspepsia (17 had ulcer-like dyspepsia), 35 had irritable bowel syndrome (IBS) without dyspepsia, and 77 were asymptomatic. The proportion who were seropositive for HP were 17% in dyspepsia (24% in ulcer-like dyspepsia), 20% in IBS, and 12% in asymptomatic controls. HP was not associated with dyspepsia, ulcer-like dyspepsia, or IBS after adjusting for age. Pepsinogen levels and serum gastrin were not associated with any of the conditions studied. However, CagA antibody positivity was associated with IBS (p < 0.05), and a borderline statistically significant association with dyspepsia was detected (p = 0.08). CONCLUSIONS: In this community, HP infection overall does not seem to explain dyspepsia, although the role of CagA-positive HP strains deserve further study. (C) 2000 by Am. Coll. of Gastroenterology.

AB - OBJECTIVE: The role of Helicobacter pylori (HP) infection in dyspepsia in the absence of peptic ulcer remains controversial. Specific attributes of the organism or the host response may be important. We aimed to determine whether HP infection overall, CagA status, serum gastrin, or serum pepsinogen levels are associated with dyspepsia in the community. METHODS: A self-report bowel disease questionnaire was mailed to a random sample of Olmsted County, Minnesota residents, aged 20-50 yr. All respondents who reported symptoms of dyspepsia or irritable bowel syndrome (cases) and all respondents without significant GI symptoms (controls) were invited to participate (n = 260). They were each assessed by a physician and their medical records reviewed. Serum was obtained to measure HP and CagA antibodies, pepsinogen I and II levels, and basal serum gastrin using validated assays. RESULTS: Of the 148 (57%) subjects who agreed to participate, 36 had dyspepsia (17 had ulcer-like dyspepsia), 35 had irritable bowel syndrome (IBS) without dyspepsia, and 77 were asymptomatic. The proportion who were seropositive for HP were 17% in dyspepsia (24% in ulcer-like dyspepsia), 20% in IBS, and 12% in asymptomatic controls. HP was not associated with dyspepsia, ulcer-like dyspepsia, or IBS after adjusting for age. Pepsinogen levels and serum gastrin were not associated with any of the conditions studied. However, CagA antibody positivity was associated with IBS (p < 0.05), and a borderline statistically significant association with dyspepsia was detected (p = 0.08). CONCLUSIONS: In this community, HP infection overall does not seem to explain dyspepsia, although the role of CagA-positive HP strains deserve further study. (C) 2000 by Am. Coll. of Gastroenterology.

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