Heart Regeneration. The Developmental and Stem Cell Biology Approach.

Almudena Martinez-Fernandez, Rosanna Beraldi, Susana Cantero Peral, Andre Terzic, Timothy J. Nelson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Regenerative Medicine is a discipline that aims at reinstating physical and functional integrity of a damaged organ via rejuvenation with endogenous stem cells, replacement with bioengineered tissues, and regeneration with transplantation of exogenous stem cells. In the case of the heart, the possibility of replacing dysfunctional myocardium with de novo tissue offers a curative approach to augment traditional management strategies to prevent disease progression toward heart failure. Across a broad range of acquired and/or congenital cardiac diseases, regenerative strategies are being optimized for individual patients with the goal of providing disruptive technology that aims to transform therapeutic outcomes and reduce the overall expenditure required for life-long disease management. Developmental biology provides a firm foundation to accelerate stem cell technologies toward cardiac clinical applications for transplant medicine and surgery.

Original languageEnglish (US)
Title of host publicationRegenerative Medicine Applications in Organ Transplantation
PublisherElsevier Inc.
Pages457-477
Number of pages21
ISBN (Print)9780123985231
DOIs
StatePublished - Jan 1 2014

Keywords

  • Cardiac regeneration
  • Cardiac stem cells
  • Cardiogenesis
  • Congenital heart disease
  • Developmental biology
  • Heart failure
  • Induced pluripotent stem cells
  • Ischemic heart disease
  • Stem cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Martinez-Fernandez, A., Beraldi, R., Cantero Peral, S., Terzic, A., & Nelson, T. J. (2014). Heart Regeneration. The Developmental and Stem Cell Biology Approach. In Regenerative Medicine Applications in Organ Transplantation (pp. 457-477). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-398523-1.00031-8