Head position during sleep: Potential implications for patients with neurodegenerative disease

Daniel J. Levendowski, Charlene Gamaldo, Erik K St Louis, Luigi Ferini-Strambi, Joanne M. Hamilton, David Salat, Philip R. Westbrook, Chris Berka

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The characterization of sleep in those with neurodegenerative disease (NDD) is essential in understanding the potential neurobiological mechanisms that underlie the connection between sleep disruption and NDD manifestations and progression. Objective: Explore the inter-relationships between NDD and age, sex, diagnosis of obstructive sleep apnea, snoring, and duration of sleep time with the head in the supine and non-supine positions. Methods: A case-control design was used to evaluate differences in sleep position obtained from multi-night, in-home Sleep Profiler recordings in 45 patients with diagnosed NDD (24 with mild cognitive impairment, 15 with Alzheimer's disease, and 6 with Lewy Body, Parkinson's, or other dementias) and 120 age-sex matched controls with normal cognition (NC). Results: The frequency of supine sleep 2 h/night was significantly greater in the NDD than in the NC group (p < 0.001, odds ratio = 3.7), and remained significant after controlling for age, sex, snoring, and obstructive sleep apnea diagnosis (p = 0.01). There were no group differences in nocturnal mobility i.e., number of head position changes/h. Conclusion: This study demonstrates the utility of in-home measurements of sleep in defining the association of supine sleep position with neurodegenerative disorders. Our findings warrant further investigation, particularly in light of the recent evidence suggesting that sleep may an active role in the brain's ability to clear CNS neurotoxins and metabolites.

Original languageEnglish (US)
Pages (from-to)631-638
Number of pages8
JournalJournal of Alzheimer's Disease
Volume67
Issue number2
DOIs
StatePublished - Jan 1 2019

Fingerprint

Neurodegenerative Diseases
Sleep
Head
Snoring
Obstructive Sleep Apnea
Cognition
Lewy Bodies
Aptitude
Supine Position
Neurotoxins
Dementia
Disease Progression
Odds Ratio
Brain

Keywords

  • Head position
  • neurodegeneration
  • obstructive sleep apnea
  • sleep
  • supine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Levendowski, D. J., Gamaldo, C., St Louis, E. K., Ferini-Strambi, L., Hamilton, J. M., Salat, D., ... Berka, C. (2019). Head position during sleep: Potential implications for patients with neurodegenerative disease. Journal of Alzheimer's Disease, 67(2), 631-638. https://doi.org/10.3233/JAD-180697

Head position during sleep : Potential implications for patients with neurodegenerative disease. / Levendowski, Daniel J.; Gamaldo, Charlene; St Louis, Erik K; Ferini-Strambi, Luigi; Hamilton, Joanne M.; Salat, David; Westbrook, Philip R.; Berka, Chris.

In: Journal of Alzheimer's Disease, Vol. 67, No. 2, 01.01.2019, p. 631-638.

Research output: Contribution to journalArticle

Levendowski, DJ, Gamaldo, C, St Louis, EK, Ferini-Strambi, L, Hamilton, JM, Salat, D, Westbrook, PR & Berka, C 2019, 'Head position during sleep: Potential implications for patients with neurodegenerative disease', Journal of Alzheimer's Disease, vol. 67, no. 2, pp. 631-638. https://doi.org/10.3233/JAD-180697
Levendowski, Daniel J. ; Gamaldo, Charlene ; St Louis, Erik K ; Ferini-Strambi, Luigi ; Hamilton, Joanne M. ; Salat, David ; Westbrook, Philip R. ; Berka, Chris. / Head position during sleep : Potential implications for patients with neurodegenerative disease. In: Journal of Alzheimer's Disease. 2019 ; Vol. 67, No. 2. pp. 631-638.
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