Hairy cell leukemia with CCND1/IGH fusion gene and BRAF V600E mutation

Zaid Abdel Rahman; Firas Muwalla; Liuyan Jiang; James Foran

doi:10.1016/j.lrr.2020.100197

Hairy cell leukemia with CCND1/IGH fusion gene and BRAF V600E mutation

Zaid Abdel Rahman, Firas Muwalla, Liuyan Jiang, James Foran

Hematology / Oncology / Cancer Center / Breast Clinic

Research output: Contribution to journal › Article › peer-review

Abstract

A 75-year-old male evaluated for pancytopenia. Abnormal lymphocytes with hairy projections noted on peripheral blood. Bone marrow examination showed diffuse proliferation of CD20+ B-lymphocytes. Flowcytometry revealed monoclonal lambda-restricted B-cells expressing CD19, CD20, CD11c, CD103, CD25 and CD123, negative for CD5 and CD10. Additional staining showed positivity for cyclin-D1, Annexin-A1 and TRAP. FISH identified t(11;14). PCR was positive for BRAF V600E. Given the above findings, nonspecificity of t(11;14) and the presence of BRAF V600E; the diagnosis of HCL was favored. Patient achieved CR with infusional cladribine. Herein, we report the co-occurrence of CCND1/IGH and BRAF V600E in HCL, a rare scenario that could characterize a new subtype of HCL.

Original language	English (US)
Article number	100197
Journal	Leukemia Research Reports
Volume	13
DOIs	https://doi.org/10.1016/j.lrr.2020.100197
State	Published - 2020

Keywords

BRAF V600E
CCND1
Hairy cell
t(11;14)

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.lrr.2020.100197

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@article{ba6d6f95187d4b6b9993dae698b004a1,

title = "Hairy cell leukemia with CCND1/IGH fusion gene and BRAF V600E mutation",

abstract = "A 75-year-old male evaluated for pancytopenia. Abnormal lymphocytes with hairy projections noted on peripheral blood. Bone marrow examination showed diffuse proliferation of CD20+ B-lymphocytes. Flowcytometry revealed monoclonal lambda-restricted B-cells expressing CD19, CD20, CD11c, CD103, CD25 and CD123, negative for CD5 and CD10. Additional staining showed positivity for cyclin-D1, Annexin-A1 and TRAP. FISH identified t(11;14). PCR was positive for BRAF V600E. Given the above findings, nonspecificity of t(11;14) and the presence of BRAF V600E; the diagnosis of HCL was favored. Patient achieved CR with infusional cladribine. Herein, we report the co-occurrence of CCND1/IGH and BRAF V600E in HCL, a rare scenario that could characterize a new subtype of HCL.",

keywords = "BRAF V600E, CCND1, Hairy cell, t(11;14)",

author = "Rahman, {Zaid Abdel} and Firas Muwalla and Liuyan Jiang and James Foran",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

doi = "10.1016/j.lrr.2020.100197",

language = "English (US)",

volume = "13",

journal = "Leukemia Research Reports",

issn = "2213-0489",

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TY - JOUR

T1 - Hairy cell leukemia with CCND1/IGH fusion gene and BRAF V600E mutation

AU - Rahman, Zaid Abdel

AU - Muwalla, Firas

AU - Jiang, Liuyan

AU - Foran, James

PY - 2020

Y1 - 2020

N2 - A 75-year-old male evaluated for pancytopenia. Abnormal lymphocytes with hairy projections noted on peripheral blood. Bone marrow examination showed diffuse proliferation of CD20+ B-lymphocytes. Flowcytometry revealed monoclonal lambda-restricted B-cells expressing CD19, CD20, CD11c, CD103, CD25 and CD123, negative for CD5 and CD10. Additional staining showed positivity for cyclin-D1, Annexin-A1 and TRAP. FISH identified t(11;14). PCR was positive for BRAF V600E. Given the above findings, nonspecificity of t(11;14) and the presence of BRAF V600E; the diagnosis of HCL was favored. Patient achieved CR with infusional cladribine. Herein, we report the co-occurrence of CCND1/IGH and BRAF V600E in HCL, a rare scenario that could characterize a new subtype of HCL.

AB - A 75-year-old male evaluated for pancytopenia. Abnormal lymphocytes with hairy projections noted on peripheral blood. Bone marrow examination showed diffuse proliferation of CD20+ B-lymphocytes. Flowcytometry revealed monoclonal lambda-restricted B-cells expressing CD19, CD20, CD11c, CD103, CD25 and CD123, negative for CD5 and CD10. Additional staining showed positivity for cyclin-D1, Annexin-A1 and TRAP. FISH identified t(11;14). PCR was positive for BRAF V600E. Given the above findings, nonspecificity of t(11;14) and the presence of BRAF V600E; the diagnosis of HCL was favored. Patient achieved CR with infusional cladribine. Herein, we report the co-occurrence of CCND1/IGH and BRAF V600E in HCL, a rare scenario that could characterize a new subtype of HCL.

KW - BRAF V600E

KW - CCND1

KW - Hairy cell

KW - t(11;14)

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DO - 10.1016/j.lrr.2020.100197

M3 - Article

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VL - 13

JO - Leukemia Research Reports

JF - Leukemia Research Reports

M1 - 100197

ER -

Hairy cell leukemia with CCND1/IGH fusion gene and BRAF V600E mutation

Abstract

Keywords

ASJC Scopus subject areas

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