TY - JOUR
T1 - Hair growth cycle affects hair follicle destruction by ruby laser pulses
AU - Lin, Tai Yuan David
AU - Manuskiatti, Woraphong
AU - Dierickx, Christine C.
AU - Farinelli, William A.
AU - Fisher, Marnie E.
AU - Flotte, Thomas
AU - Baden, Howard P.
AU - Anderson, R. Rox
N1 - Funding Information:
We thank Dr. Valeria Duque for help with animal preparation, Bart Johnson for his help with biopsy specimens, and Norm Michaud for his help with histologic photographs. We also thank Dr. Gregory Altshuler for helpful discussions and for assistance with modeling of selective thermolysis of mouse hair follicles. This study was supported by grants from the Palomar Medical Technologies.
PY - 1998
Y1 - 1998
N2 - It has been shown that normal mode ruby laser pulses (694 nm) are effective in selectively destroying brown or black pigmented hair follicles in adult Caucasians. This study investigated how the various stages of the hair follicle growth cycle influence follicle destruction by ruby laser treatment, using a model of predictable synchronous hair growth cycles in the infantile and adolescent mice. A range of ruby laser pulse fluences was delivered during different stages of the hair growth cycle, followed by histologic and gross observations of the injury and regrowth of hair. Actively growing and pigmented anagen stage hair follicles were sensitive to hair removal by normal mode ruby laser exposure, whereas catagen and telogen stage hair follicles were resistant to laser irradiation. Selective thermal injury to follicles was observed histologically, and hair regrowth was fluence dependent. In animals exposed during anagen, intermediate fluences induced nonscarring alopecia, whereas high fluences induced scarring alopecia. The findings of this study suggest treatment strategies for optimal laser hair removal.
AB - It has been shown that normal mode ruby laser pulses (694 nm) are effective in selectively destroying brown or black pigmented hair follicles in adult Caucasians. This study investigated how the various stages of the hair follicle growth cycle influence follicle destruction by ruby laser treatment, using a model of predictable synchronous hair growth cycles in the infantile and adolescent mice. A range of ruby laser pulse fluences was delivered during different stages of the hair growth cycle, followed by histologic and gross observations of the injury and regrowth of hair. Actively growing and pigmented anagen stage hair follicles were sensitive to hair removal by normal mode ruby laser exposure, whereas catagen and telogen stage hair follicles were resistant to laser irradiation. Selective thermal injury to follicles was observed histologically, and hair regrowth was fluence dependent. In animals exposed during anagen, intermediate fluences induced nonscarring alopecia, whereas high fluences induced scarring alopecia. The findings of this study suggest treatment strategies for optimal laser hair removal.
KW - C57BL6
KW - Hair removal
KW - Selective thermolysis
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U2 - 10.1046/j.1523-1747.1998.00227.x
DO - 10.1046/j.1523-1747.1998.00227.x
M3 - Article
C2 - 9665395
AN - SCOPUS:0031803641
SN - 0022-202X
VL - 111
SP - 107
EP - 113
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 1
ER -