Hair growth cycle affects hair follicle destruction by ruby laser pulses

Tai Yuan David Lin, Woraphong Manuskiatti, Christine C. Dierickx, William A. Farinelli, Marnie E. Fisher, Thomas J Flotte, Howard P. Baden, R. Rox Anderson

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

It has been shown that normal mode ruby laser pulses (694 nm) are effective in selectively destroying brown or black pigmented hair follicles in adult Caucasians. This study investigated how the various stages of the hair follicle growth cycle influence follicle destruction by ruby laser treatment, using a model of predictable synchronous hair growth cycles in the infantile and adolescent mice. A range of ruby laser pulse fluences was delivered during different stages of the hair growth cycle, followed by histologic and gross observations of the injury and regrowth of hair. Actively growing and pigmented anagen stage hair follicles were sensitive to hair removal by normal mode ruby laser exposure, whereas catagen and telogen stage hair follicles were resistant to laser irradiation. Selective thermal injury to follicles was observed histologically, and hair regrowth was fluence dependent. In animals exposed during anagen, intermediate fluences induced nonscarring alopecia, whereas high fluences induced scarring alopecia. The findings of this study suggest treatment strategies for optimal laser hair removal.

Original languageEnglish (US)
Pages (from-to)107-113
Number of pages7
JournalJournal of Investigative Dermatology
Volume111
Issue number1
DOIs
StatePublished - 1998
Externally publishedYes

Fingerprint

Ruby
Hair Follicle
Solid-State Lasers
Hair
Laser pulses
Hair Removal
Alopecia
Growth
Laser modes
Lasers
Wounds and Injuries
Laser beam effects
Cicatrix
Animals
Hot Temperature
Therapeutics

Keywords

  • C57BL6
  • Hair removal
  • Selective thermolysis

ASJC Scopus subject areas

  • Dermatology

Cite this

Lin, T. Y. D., Manuskiatti, W., Dierickx, C. C., Farinelli, W. A., Fisher, M. E., Flotte, T. J., ... Anderson, R. R. (1998). Hair growth cycle affects hair follicle destruction by ruby laser pulses. Journal of Investigative Dermatology, 111(1), 107-113. https://doi.org/10.1046/j.1523-1747.1998.00227.x

Hair growth cycle affects hair follicle destruction by ruby laser pulses. / Lin, Tai Yuan David; Manuskiatti, Woraphong; Dierickx, Christine C.; Farinelli, William A.; Fisher, Marnie E.; Flotte, Thomas J; Baden, Howard P.; Anderson, R. Rox.

In: Journal of Investigative Dermatology, Vol. 111, No. 1, 1998, p. 107-113.

Research output: Contribution to journalArticle

Lin, TYD, Manuskiatti, W, Dierickx, CC, Farinelli, WA, Fisher, ME, Flotte, TJ, Baden, HP & Anderson, RR 1998, 'Hair growth cycle affects hair follicle destruction by ruby laser pulses', Journal of Investigative Dermatology, vol. 111, no. 1, pp. 107-113. https://doi.org/10.1046/j.1523-1747.1998.00227.x
Lin, Tai Yuan David ; Manuskiatti, Woraphong ; Dierickx, Christine C. ; Farinelli, William A. ; Fisher, Marnie E. ; Flotte, Thomas J ; Baden, Howard P. ; Anderson, R. Rox. / Hair growth cycle affects hair follicle destruction by ruby laser pulses. In: Journal of Investigative Dermatology. 1998 ; Vol. 111, No. 1. pp. 107-113.
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