Guidelines for carotid endarterectomy: A multidisciplinary consensus statement from the ad hoc committee, American heart association

Wesley S. Moore, H. J.M. Barnett, Hugh G. Beebe, Eugene F. Bernstein, Bruce J. Brener, Thomas Brott, Louis R. Caplan, Arthur Day, Jerry Goldstone, Robert W. Hobson, Richard F. Kempczinski, David B. Matchar, Marc R. Mayberg, Andrew N. Nicolaides, John W. Norris, John J. Ricotta, James T. Robertson, Robert B. Rutherford, David Thomas, James F. TooleHugh H. Trout, David O. Wiebers

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Abstract

Indications for carotid endarterectomy have engendered considerable debate among experts and have resulted in publication of retrospective reviews, natural history studies, audits of community practice, position papers, expert opinion statements, and finally prospective randomized trials. The American Heart Association assembled a group of experts in a multidisciplinary consensus conference to develop this statement. Methods A conference was held July 16-18, 1993, in Park City, Utah, that included recognized experts in neurology, neurosurgery, vascular surgery, and healthcare planning. A program of critical topics was developed, and each expert presented a talk and provided the chairman with a summary statement. From these summary statements a document was developed and edited onsite to achieve consensus before final revision. Results The first section of this document reviews the natural history, methods of patient evaluation, options for medical management, results of surgical management, data from position statements, and results to date of prospective randomized trials for symptomatic and asymptomatic patients with carotid artery disease. The second section divides 96 potential indications for carotid endarterectomy, based on surgical risk, into four categories: (1) Proven: This is the strongest indication for carotid endarterectomy; data are supported by results of prospective contemporary randomized trials. (2) Acceptable but not proven: a good indication for operation; supported by promising but not scientifically certain data. (3) Uncertain: Data are insufficient to define the risk/benefit ratio. (4) Proven inappropriate: Current data are adequate to show that the risk of surgery outweighs any benefit. Conclusions Indications for carotid endarterectomy in symptomatic good-risk patients with a surgeon whose surgical morbidity and mortality rate is less than 6% are as follows. (1) Proven: one or more TIAs in the past 6 months and carotid stenosis greater than or equal to 70% or mild stroke within 6 months and a carotid stenosis more than or equal to 70%; (2) acceptable but not proven: TIAs within the past 6 months and a stenosis 50% to 69%, progressive stroke and a stenosis greater than or equal to 70%, mild or moderate stroke in the past 6 months and a stenosis 50% to 69%, or carotid endarterectomy ipsilateral to TIAs and a stenosis greater than or equal to 70% combined with required coronary artery bypass grafting; (3) uncertain: TIAs with a stenosis less than 50%, mild stroke and stenosis less than 50%, TIAs with a stenosis less than 70% combined with coronary artery bypass grafting, or symptomatic, acute carotid thrombosis; (4) proven inappropriate: moderate stroke with stenosis less than 50%, not on aspirin; single TIA, less than 50% stenosis, not on aspirin; high-risk patient with multiple TIAs, not on aspirin, stenosis less than 50%; high-risk patient, mild or moderate stroke, stenosis less than 50%, not on aspirin; global ischemic symptoms with stenosis less than 50%; acute dissection, asymptomatic on heparin. Indications for carotid endarterectomy in asymptomatic good-risk patients performed by a surgeon whose surgical morbidity and mortality rate is less than 3% are as follows. (1) Proven: none. (As this statement went to press, the National Institute of Neurological Disorders and Stroke issued a clinical advisory stating that the Institute has halted the Asymptomatic Carotid Atherosclerosis Study (ACAS) because of a clear benefit in favor of surgery for patients with carotid stenosis greater than or eaual yo 60% as measured by diameter reduction. When the ACAS report is published, this indication will be recategorized as proven. (2) acceptable but not proven: stenosis greater than 75% by linear diameter; (3) uncertain: stenosis greater than 75% in a high-risk patient/surgeon (surgical morbidity and mortality rate greater than 3%), combined carotid/coronary operations, or ulcerative lesions without hemodynamically significant stenosis; (4) proven inappropriate: operations with a combined stroke morbidity and mortality greater than 5%.

Original languageEnglish (US)
Pages (from-to)188-201
Number of pages14
JournalStroke
Volume26
Issue number1
DOIs
StatePublished - Jan 1995

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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    Moore, W. S., Barnett, H. J. M., Beebe, H. G., Bernstein, E. F., Brener, B. J., Brott, T., Caplan, L. R., Day, A., Goldstone, J., Hobson, R. W., Kempczinski, R. F., Matchar, D. B., Mayberg, M. R., Nicolaides, A. N., Norris, J. W., Ricotta, J. J., Robertson, J. T., Rutherford, R. B., Thomas, D., ... Wiebers, D. O. (1995). Guidelines for carotid endarterectomy: A multidisciplinary consensus statement from the ad hoc committee, American heart association. Stroke, 26(1), 188-201. https://doi.org/10.1161/01.STR.26.1.188