Growth patterns of fetal lung volumes in healthy fetuses and fetuses with isolated left-sided congenital diaphragmatic hernia

Rodrigo Ruano, Ingrid Schwach Werneck Britto, Nicolas Sananes, Wesley Lee, Haleh Sangi-Haghpeykar, Russell L. Deter

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives - To evaluate fetal lung growth using 3-dimensional sonography in healthy fetuses and those with congenital diaphragmatic hernia (CDH). Methods - Right and total lung volumes were serially evaluated by 3-dimensional sonography in 66 healthy fetuses and 52 fetuses with left-sided CDH between 20 and 37 weeks' menstrual age. Functions fitted to these parameters were compared for 2 groups: (1) healthy versus those with CDH; and (2) fetuses with CHD who survived versus those who died. Results - Fetal right and total lung volumes as well as fetal observed-to-expected right and total lung volume ratios were significantly lower in fetuses with CDH than healthy fetuses (P < .001) and in those fetuses with CDH who died (P < .001). The observed-to-expected right and total lung volume ratios did not vary with menstrual age in healthy fetuses or in those with CDH (independent of outcome). Conclusions - Lung volume rates were lower in fetuses with left-sided CDH compared to healthy fetuses, as well as in fetuses with CDH who died compared to those who survived. The observed-to-expected right and total lung volume ratios were relatively constant throughout menstrual age in fetuses with left-sided CDH, suggesting that the origin of their lung growth abnormalities occurred before 20 weeks and did not progress. The observed-to-expected ratios may be useful in predicting the outcome in fetuses with CDH independent of menstrual age.

Original languageEnglish (US)
Pages (from-to)1159-1166
Number of pages8
JournalJournal of Ultrasound in Medicine
Volume35
Issue number6
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

Fingerprint

Fetal Development
Fetus
Lung
Congenital Diaphragmatic Hernias
Ultrasonography

Keywords

  • 3-Dimensional sonography
  • Congenital diaphragmatic hernia
  • Fetal lung
  • Fetal lung volume
  • Obstetric ultrasound
  • Prenatal diagnosis
  • Pulmonary hypoplasia

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Growth patterns of fetal lung volumes in healthy fetuses and fetuses with isolated left-sided congenital diaphragmatic hernia. / Ruano, Rodrigo; Britto, Ingrid Schwach Werneck; Sananes, Nicolas; Lee, Wesley; Sangi-Haghpeykar, Haleh; Deter, Russell L.

In: Journal of Ultrasound in Medicine, Vol. 35, No. 6, 01.06.2016, p. 1159-1166.

Research output: Contribution to journalArticle

Ruano, Rodrigo ; Britto, Ingrid Schwach Werneck ; Sananes, Nicolas ; Lee, Wesley ; Sangi-Haghpeykar, Haleh ; Deter, Russell L. / Growth patterns of fetal lung volumes in healthy fetuses and fetuses with isolated left-sided congenital diaphragmatic hernia. In: Journal of Ultrasound in Medicine. 2016 ; Vol. 35, No. 6. pp. 1159-1166.
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abstract = "Objectives - To evaluate fetal lung growth using 3-dimensional sonography in healthy fetuses and those with congenital diaphragmatic hernia (CDH). Methods - Right and total lung volumes were serially evaluated by 3-dimensional sonography in 66 healthy fetuses and 52 fetuses with left-sided CDH between 20 and 37 weeks' menstrual age. Functions fitted to these parameters were compared for 2 groups: (1) healthy versus those with CDH; and (2) fetuses with CHD who survived versus those who died. Results - Fetal right and total lung volumes as well as fetal observed-to-expected right and total lung volume ratios were significantly lower in fetuses with CDH than healthy fetuses (P < .001) and in those fetuses with CDH who died (P < .001). The observed-to-expected right and total lung volume ratios did not vary with menstrual age in healthy fetuses or in those with CDH (independent of outcome). Conclusions - Lung volume rates were lower in fetuses with left-sided CDH compared to healthy fetuses, as well as in fetuses with CDH who died compared to those who survived. The observed-to-expected right and total lung volume ratios were relatively constant throughout menstrual age in fetuses with left-sided CDH, suggesting that the origin of their lung growth abnormalities occurred before 20 weeks and did not progress. The observed-to-expected ratios may be useful in predicting the outcome in fetuses with CDH independent of menstrual age.",
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AU - Britto, Ingrid Schwach Werneck

AU - Sananes, Nicolas

AU - Lee, Wesley

AU - Sangi-Haghpeykar, Haleh

AU - Deter, Russell L.

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N2 - Objectives - To evaluate fetal lung growth using 3-dimensional sonography in healthy fetuses and those with congenital diaphragmatic hernia (CDH). Methods - Right and total lung volumes were serially evaluated by 3-dimensional sonography in 66 healthy fetuses and 52 fetuses with left-sided CDH between 20 and 37 weeks' menstrual age. Functions fitted to these parameters were compared for 2 groups: (1) healthy versus those with CDH; and (2) fetuses with CHD who survived versus those who died. Results - Fetal right and total lung volumes as well as fetal observed-to-expected right and total lung volume ratios were significantly lower in fetuses with CDH than healthy fetuses (P < .001) and in those fetuses with CDH who died (P < .001). The observed-to-expected right and total lung volume ratios did not vary with menstrual age in healthy fetuses or in those with CDH (independent of outcome). Conclusions - Lung volume rates were lower in fetuses with left-sided CDH compared to healthy fetuses, as well as in fetuses with CDH who died compared to those who survived. The observed-to-expected right and total lung volume ratios were relatively constant throughout menstrual age in fetuses with left-sided CDH, suggesting that the origin of their lung growth abnormalities occurred before 20 weeks and did not progress. The observed-to-expected ratios may be useful in predicting the outcome in fetuses with CDH independent of menstrual age.

AB - Objectives - To evaluate fetal lung growth using 3-dimensional sonography in healthy fetuses and those with congenital diaphragmatic hernia (CDH). Methods - Right and total lung volumes were serially evaluated by 3-dimensional sonography in 66 healthy fetuses and 52 fetuses with left-sided CDH between 20 and 37 weeks' menstrual age. Functions fitted to these parameters were compared for 2 groups: (1) healthy versus those with CDH; and (2) fetuses with CHD who survived versus those who died. Results - Fetal right and total lung volumes as well as fetal observed-to-expected right and total lung volume ratios were significantly lower in fetuses with CDH than healthy fetuses (P < .001) and in those fetuses with CDH who died (P < .001). The observed-to-expected right and total lung volume ratios did not vary with menstrual age in healthy fetuses or in those with CDH (independent of outcome). Conclusions - Lung volume rates were lower in fetuses with left-sided CDH compared to healthy fetuses, as well as in fetuses with CDH who died compared to those who survived. The observed-to-expected right and total lung volume ratios were relatively constant throughout menstrual age in fetuses with left-sided CDH, suggesting that the origin of their lung growth abnormalities occurred before 20 weeks and did not progress. The observed-to-expected ratios may be useful in predicting the outcome in fetuses with CDH independent of menstrual age.

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