Growth-Hormone Dynamics in Healthy Adults are Related to Age and Sex, and Strongly Dependent on Body Mass Index

Ferdinand Roelfsema, Johannes D Veldhuis

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Context: Studies on 24-hour growth hormone (GH) secretion are rare. The influence of sex, age and adiposity are well recognized but generally derived from specific selected subject groups, not spanning sexes, many age decades, and a range of body weights. Objective: The goal was to investigate GH dynamics in a group of 130 healthy adult subjects, both men and women, across 5 age decades, and a 2.5 fold range of body mass index (BMI). Methods: GH was measured by a sensitive immunofluorometric assay. Secretion parameters were quantified by automated deconvolution and relative pattern randomness by approximate entropy (ApEn). Results: Median age was 40, range 20-77 year. Median BMI was 26, range 18.3-49.8 kg/m2. Pulsatile 24-hour GH secretion was negatively correlated with age (p = 0.002) and BMI (p <0.0001). Basal GH secretion negatively correlated with BMI (p = 0.003) and not with age. The sex-dependent GH secretion (larger in women) was no longer detectable after 50 year. IGF-1 levels were lower in women after 50 year compared with men of similar age. ApEn showed age-related increase in both sexes and was higher in premenopausal and postmenopausal women than men of comparable age (p <0.0001). A single fasting GH measurement is non-informative of 24-hour GH secretion. Conclusion: BMI dominates the negative regulation of 24-hour GH secretion across 5 decades of age in this till now largest cohort of healthy adults, who underwent 24-hour blood sampling. Sex also impacts GH secretion before age 50 year and its regularity at all ages. Serum IGF-I differences partly depend on pre- or postmenopausal state. Finally, a single GH measurement is not informative of 24-hour GH secretion.

Original languageEnglish (US)
JournalNeuroendocrinology
DOIs
StateAccepted/In press - Jul 28 2015

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Growth Hormone
Body Mass Index
Entropy
Insulin-Like Growth Factor I
Fluoroimmunoassay
Adiposity
Fasting
Healthy Volunteers
Body Weight

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

Cite this

Growth-Hormone Dynamics in Healthy Adults are Related to Age and Sex, and Strongly Dependent on Body Mass Index. / Roelfsema, Ferdinand; Veldhuis, Johannes D.

In: Neuroendocrinology, 28.07.2015.

Research output: Contribution to journalArticle

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