Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice

Michael B. Stout, Tamara Tchkonia, Tamar Pirtskhalava, Allyson K. Palmer, Edward O. List, Darlene E. Berryman, Ellen R. Lubbers, Carlos Escande, Adam Spong, Michal M. Masternak, Ann L Oberg, Nathan K LeBrasseur, Richard A. Miller, John J. Kopchick, Andrzej Bartke, James L Kirkland

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The aging process is associated with the development of several chronic diseases. White adipose tissue (WAT) may play a central role in age-related disease onset and progression due to declines in adipogenesis with advancing age. Recent reports indicate that the accumulation of senescent progenitor cells may be involved in age-related WAT dysfunction. Growth hormone (GH) action has profound effects on adiposity and metabolism and is known to influence lifespan. In the present study we tested the hypothesis that GH activity would predict age-related WAT dysfunction and accumulation of senescent cells. We found that long-lived GH-deficient and -resistant mice have reduced age-related lipid redistribution. Primary preadipocytes from GH-resistant mice also were found to have greater differentiation capacity at 20 months of age when compared to controls. GH activity was also found to be positively associated with senescent cell accumulation in WAT. Our results demonstrate an association between GH activity, age-related WAT dysfunction, and WAT senescent cell accumulation in mice. Further studies are needed to determine if GH is directly inducing cellular senescence in WAT or if GH actions on other target organs or alternative downstream alterations in insulin-like growth factor-1, insulin or glucose levels are responsible.

Original languageEnglish (US)
Pages (from-to)575-586
Number of pages12
JournalAging
Volume6
Issue number7
StatePublished - 2014

Fingerprint

White Adipose Tissue
Growth Hormone
Adipogenesis
Cell Aging
Adiposity
Somatomedins
Disease Progression
Chronic Disease
Stem Cells
Insulin
Lipids
Glucose

Keywords

  • Adipose tissue
  • Aging
  • Cellular senescence
  • Growth hormone

ASJC Scopus subject areas

  • Aging
  • Cell Biology
  • Medicine(all)

Cite this

Stout, M. B., Tchkonia, T., Pirtskhalava, T., Palmer, A. K., List, E. O., Berryman, D. E., ... Kirkland, J. L. (2014). Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice. Aging, 6(7), 575-586.

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice. / Stout, Michael B.; Tchkonia, Tamara; Pirtskhalava, Tamar; Palmer, Allyson K.; List, Edward O.; Berryman, Darlene E.; Lubbers, Ellen R.; Escande, Carlos; Spong, Adam; Masternak, Michal M.; Oberg, Ann L; LeBrasseur, Nathan K; Miller, Richard A.; Kopchick, John J.; Bartke, Andrzej; Kirkland, James L.

In: Aging, Vol. 6, No. 7, 2014, p. 575-586.

Research output: Contribution to journalArticle

Stout, MB, Tchkonia, T, Pirtskhalava, T, Palmer, AK, List, EO, Berryman, DE, Lubbers, ER, Escande, C, Spong, A, Masternak, MM, Oberg, AL, LeBrasseur, NK, Miller, RA, Kopchick, JJ, Bartke, A & Kirkland, JL 2014, 'Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice', Aging, vol. 6, no. 7, pp. 575-586.
Stout MB, Tchkonia T, Pirtskhalava T, Palmer AK, List EO, Berryman DE et al. Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice. Aging. 2014;6(7):575-586.
Stout, Michael B. ; Tchkonia, Tamara ; Pirtskhalava, Tamar ; Palmer, Allyson K. ; List, Edward O. ; Berryman, Darlene E. ; Lubbers, Ellen R. ; Escande, Carlos ; Spong, Adam ; Masternak, Michal M. ; Oberg, Ann L ; LeBrasseur, Nathan K ; Miller, Richard A. ; Kopchick, John J. ; Bartke, Andrzej ; Kirkland, James L. / Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice. In: Aging. 2014 ; Vol. 6, No. 7. pp. 575-586.
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