GRN 3′UTR+78 C>T is not associated with risk for Parkinson's disease

B. Jasinska-Myga; C. Wider; G. Opala; A. Krygowska-Wajs; M. Barcikowska; K. Czyzewski; M. Baker; R. Rademakers; R. J. Uitti; M. J. Farrer; O. A. Ross; Z. K. Wszolek

doi:10.1111/j.1468-1331.2009.02621.x

GRN 3′UTR+78 C>T is not associated with risk for Parkinson's disease

B. Jasinska-Myga, C. Wider, G. Opala, A. Krygowska-Wajs, M. Barcikowska, K. Czyzewski, M. Baker, R. Rademakers, R. J. Uitti, M. J. Farrer, O. A. Ross, Z. K. Wszolek

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Background and purpose: A single nucleotide polymorphism in the 3′-untranslated region of the progranulin gene (GRN; 3′UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). rs5848 is located within a micro-RNA binding site and affects the expression of GRN. Methods: As FTLD-U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinson's disease in two Caucasian patient-control series (n = 1413) from the US and Poland. Results: No association was observed between rs5848 and susceptibility to Parkinson's disease (individual series and combined analysis). Conclusions: This finding shows that GRN rs5848 does not affect the risk of Parkinson's disease in the US and Polish populations.

Original language	English (US)
Pages (from-to)	909-911
Number of pages	3
Journal	European Journal of Neurology
Volume	16
Issue number	8
DOIs	https://doi.org/10.1111/j.1468-1331.2009.02621.x
State	Published - Aug 2009

Keywords

GRN
Genetics
MiRNA
Parkinson's disease
Rs5848
SNP

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1111/j.1468-1331.2009.02621.x

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title = "GRN 3′UTR+78 C>T is not associated with risk for Parkinson's disease",

abstract = "Background and purpose: A single nucleotide polymorphism in the 3′-untranslated region of the progranulin gene (GRN; 3′UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). rs5848 is located within a micro-RNA binding site and affects the expression of GRN. Methods: As FTLD-U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinson's disease in two Caucasian patient-control series (n = 1413) from the US and Poland. Results: No association was observed between rs5848 and susceptibility to Parkinson's disease (individual series and combined analysis). Conclusions: This finding shows that GRN rs5848 does not affect the risk of Parkinson's disease in the US and Polish populations.",

keywords = "GRN, Genetics, MiRNA, Parkinson's disease, Rs5848, SNP",

author = "B. Jasinska-Myga and C. Wider and G. Opala and A. Krygowska-Wajs and M. Barcikowska and K. Czyzewski and M. Baker and R. Rademakers and Uitti, {R. J.} and Farrer, {M. J.} and Ross, {O. A.} and Wszolek, {Z. K.}",

year = "2009",

month = aug,

doi = "10.1111/j.1468-1331.2009.02621.x",

language = "English (US)",

volume = "16",

pages = "909--911",

journal = "European Journal of Neurology",

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T1 - GRN 3′UTR+78 C>T is not associated with risk for Parkinson's disease

AU - Jasinska-Myga, B.

AU - Wider, C.

AU - Opala, G.

AU - Krygowska-Wajs, A.

AU - Barcikowska, M.

AU - Czyzewski, K.

AU - Baker, M.

AU - Rademakers, R.

AU - Uitti, R. J.

AU - Farrer, M. J.

AU - Ross, O. A.

AU - Wszolek, Z. K.

PY - 2009/8

Y1 - 2009/8

N2 - Background and purpose: A single nucleotide polymorphism in the 3′-untranslated region of the progranulin gene (GRN; 3′UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). rs5848 is located within a micro-RNA binding site and affects the expression of GRN. Methods: As FTLD-U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinson's disease in two Caucasian patient-control series (n = 1413) from the US and Poland. Results: No association was observed between rs5848 and susceptibility to Parkinson's disease (individual series and combined analysis). Conclusions: This finding shows that GRN rs5848 does not affect the risk of Parkinson's disease in the US and Polish populations.

AB - Background and purpose: A single nucleotide polymorphism in the 3′-untranslated region of the progranulin gene (GRN; 3′UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). rs5848 is located within a micro-RNA binding site and affects the expression of GRN. Methods: As FTLD-U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinson's disease in two Caucasian patient-control series (n = 1413) from the US and Poland. Results: No association was observed between rs5848 and susceptibility to Parkinson's disease (individual series and combined analysis). Conclusions: This finding shows that GRN rs5848 does not affect the risk of Parkinson's disease in the US and Polish populations.

KW - GRN

KW - Genetics

KW - MiRNA

KW - Parkinson's disease

KW - Rs5848

KW - SNP

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GRN 3′UTR+78 C>T is not associated with risk for Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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