GRN 3′UTR+78 C>T is not associated with risk for Parkinson's disease

B. Jasinska-Myga, C. Wider, G. Opala, A. Krygowska-Wajs, M. Barcikowska, K. Czyzewski, M. Baker, R. Rademakers, R. J. Uitti, M. J. Farrer, O. A. Ross, Z. K. Wszolek

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background and purpose: A single nucleotide polymorphism in the 3′-untranslated region of the progranulin gene (GRN; 3′UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). rs5848 is located within a micro-RNA binding site and affects the expression of GRN. Methods: As FTLD-U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinson's disease in two Caucasian patient-control series (n = 1413) from the US and Poland. Results: No association was observed between rs5848 and susceptibility to Parkinson's disease (individual series and combined analysis). Conclusions: This finding shows that GRN rs5848 does not affect the risk of Parkinson's disease in the US and Polish populations.

Original languageEnglish (US)
Pages (from-to)909-911
Number of pages3
JournalEuropean Journal of Neurology
Volume16
Issue number8
DOIs
StatePublished - Aug 2009

Keywords

  • GRN
  • Genetics
  • MiRNA
  • Parkinson's disease
  • Rs5848
  • SNP

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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