GRN 3′UTR+78 C>T is not associated with risk for Parkinson's disease

B. Jasinska-Myga, C. Wider, G. Opala, A. Krygowska-Wajs, M. Barcikowska, K. Czyzewski, M. Baker, Rosa V Rademakers, R. J. Uitti, M. J. Farrer, Owen A Ross, Zbigniew K Wszolek

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background and purpose: A single nucleotide polymorphism in the 3′-untranslated region of the progranulin gene (GRN; 3′UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). rs5848 is located within a micro-RNA binding site and affects the expression of GRN. Methods: As FTLD-U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinson's disease in two Caucasian patient-control series (n = 1413) from the US and Poland. Results: No association was observed between rs5848 and susceptibility to Parkinson's disease (individual series and combined analysis). Conclusions: This finding shows that GRN rs5848 does not affect the risk of Parkinson's disease in the US and Polish populations.

Original languageEnglish (US)
Pages (from-to)909-911
Number of pages3
JournalEuropean Journal of Neurology
Volume16
Issue number8
DOIs
StatePublished - Aug 2009

Fingerprint

Parkinson Disease
Frontotemporal Dementia
Parkinsonian Disorders
3' Untranslated Regions
Poland
MicroRNAs
Single Nucleotide Polymorphism
Binding Sites
Population
Genes

Keywords

  • Genetics
  • GRN
  • MiRNA
  • Parkinson's disease
  • Rs5848
  • SNP

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Jasinska-Myga, B., Wider, C., Opala, G., Krygowska-Wajs, A., Barcikowska, M., Czyzewski, K., ... Wszolek, Z. K. (2009). GRN 3′UTR+78 C>T is not associated with risk for Parkinson's disease. European Journal of Neurology, 16(8), 909-911. https://doi.org/10.1111/j.1468-1331.2009.02621.x

GRN 3′UTR+78 C>T is not associated with risk for Parkinson's disease. / Jasinska-Myga, B.; Wider, C.; Opala, G.; Krygowska-Wajs, A.; Barcikowska, M.; Czyzewski, K.; Baker, M.; Rademakers, Rosa V; Uitti, R. J.; Farrer, M. J.; Ross, Owen A; Wszolek, Zbigniew K.

In: European Journal of Neurology, Vol. 16, No. 8, 08.2009, p. 909-911.

Research output: Contribution to journalArticle

Jasinska-Myga, B, Wider, C, Opala, G, Krygowska-Wajs, A, Barcikowska, M, Czyzewski, K, Baker, M, Rademakers, RV, Uitti, RJ, Farrer, MJ, Ross, OA & Wszolek, ZK 2009, 'GRN 3′UTR+78 C>T is not associated with risk for Parkinson's disease', European Journal of Neurology, vol. 16, no. 8, pp. 909-911. https://doi.org/10.1111/j.1468-1331.2009.02621.x
Jasinska-Myga B, Wider C, Opala G, Krygowska-Wajs A, Barcikowska M, Czyzewski K et al. GRN 3′UTR+78 C>T is not associated with risk for Parkinson's disease. European Journal of Neurology. 2009 Aug;16(8):909-911. https://doi.org/10.1111/j.1468-1331.2009.02621.x
Jasinska-Myga, B. ; Wider, C. ; Opala, G. ; Krygowska-Wajs, A. ; Barcikowska, M. ; Czyzewski, K. ; Baker, M. ; Rademakers, Rosa V ; Uitti, R. J. ; Farrer, M. J. ; Ross, Owen A ; Wszolek, Zbigniew K. / GRN 3′UTR+78 C>T is not associated with risk for Parkinson's disease. In: European Journal of Neurology. 2009 ; Vol. 16, No. 8. pp. 909-911.
@article{1037d2bb31f54582b00c4c0237cec194,
title = "GRN 3′UTR+78 C>T is not associated with risk for Parkinson's disease",
abstract = "Background and purpose: A single nucleotide polymorphism in the 3′-untranslated region of the progranulin gene (GRN; 3′UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). rs5848 is located within a micro-RNA binding site and affects the expression of GRN. Methods: As FTLD-U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinson's disease in two Caucasian patient-control series (n = 1413) from the US and Poland. Results: No association was observed between rs5848 and susceptibility to Parkinson's disease (individual series and combined analysis). Conclusions: This finding shows that GRN rs5848 does not affect the risk of Parkinson's disease in the US and Polish populations.",
keywords = "Genetics, GRN, MiRNA, Parkinson's disease, Rs5848, SNP",
author = "B. Jasinska-Myga and C. Wider and G. Opala and A. Krygowska-Wajs and M. Barcikowska and K. Czyzewski and M. Baker and Rademakers, {Rosa V} and Uitti, {R. J.} and Farrer, {M. J.} and Ross, {Owen A} and Wszolek, {Zbigniew K}",
year = "2009",
month = "8",
doi = "10.1111/j.1468-1331.2009.02621.x",
language = "English (US)",
volume = "16",
pages = "909--911",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - GRN 3′UTR+78 C>T is not associated with risk for Parkinson's disease

AU - Jasinska-Myga, B.

AU - Wider, C.

AU - Opala, G.

AU - Krygowska-Wajs, A.

AU - Barcikowska, M.

AU - Czyzewski, K.

AU - Baker, M.

AU - Rademakers, Rosa V

AU - Uitti, R. J.

AU - Farrer, M. J.

AU - Ross, Owen A

AU - Wszolek, Zbigniew K

PY - 2009/8

Y1 - 2009/8

N2 - Background and purpose: A single nucleotide polymorphism in the 3′-untranslated region of the progranulin gene (GRN; 3′UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). rs5848 is located within a micro-RNA binding site and affects the expression of GRN. Methods: As FTLD-U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinson's disease in two Caucasian patient-control series (n = 1413) from the US and Poland. Results: No association was observed between rs5848 and susceptibility to Parkinson's disease (individual series and combined analysis). Conclusions: This finding shows that GRN rs5848 does not affect the risk of Parkinson's disease in the US and Polish populations.

AB - Background and purpose: A single nucleotide polymorphism in the 3′-untranslated region of the progranulin gene (GRN; 3′UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). rs5848 is located within a micro-RNA binding site and affects the expression of GRN. Methods: As FTLD-U patients often present with parkinsonism, we investigated the association of GRN rs5848 and risk of Parkinson's disease in two Caucasian patient-control series (n = 1413) from the US and Poland. Results: No association was observed between rs5848 and susceptibility to Parkinson's disease (individual series and combined analysis). Conclusions: This finding shows that GRN rs5848 does not affect the risk of Parkinson's disease in the US and Polish populations.

KW - Genetics

KW - GRN

KW - MiRNA

KW - Parkinson's disease

KW - Rs5848

KW - SNP

UR - http://www.scopus.com/inward/record.url?scp=67651250941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651250941&partnerID=8YFLogxK

U2 - 10.1111/j.1468-1331.2009.02621.x

DO - 10.1111/j.1468-1331.2009.02621.x

M3 - Article

C2 - 19473366

AN - SCOPUS:67651250941

VL - 16

SP - 909

EP - 911

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 8

ER -