Graves' Dermopathy and Acropachy Are Markers of Severe Graves' Ophthalmopathy

Vahab Fatourechi, George B. Bartley, Guiti Z. Eghbali-Fatourechi, Claudia C. Powell, Debra D.F. Ahmed, James A. Garrity

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

It is generally considered that thyroid dermopathy and acropachy almost always occur with Graves' ophthalmopathy and that these two extrathyroidal manifestations are indicators of severe autoimmune disease and hence of more severe ophthalmopathy. However, documentation of these anecdotal impressions is needed. We assessed the presence of optic neuropathy and frequency of orbital decompression in 2 referral cohorts: 40 patients with acropachy and dermopathy (acropachy group) and 138 patients with Graves' dermopathy and no acropachy (dermopathy group). We compared those cohorts with a cohort of 114 patients who had ophthalmopathy without dermopathy and acropachy (control group). We considered optic neuropathy and the need for orbital decompression to be indicators of severe Graves' ophthalmopathy. The frequency of orbital decompression was significantly higher in the dermopathy group than in the control group (odds ratio, 3.55) and even higher in the acropachy group (odds ratios: 20.68 for acropachy group compared with control group; 5.83 for acropachy group compared with dermopathy group). The same trend occurred with optic neuropathy but was not statistically significant (α = 0.05; p = 0.07). Five patients were exceptions: they had definite Graves' dermopathy without clinically obvious ophthalmopathy. In conclusion, dermopathy and acropachy appear to be markers of severe ophthalmopathy. Occasionally, however, Graves' dermopathy occurs without clinical ophthalmopathy.

Original languageEnglish (US)
Pages (from-to)1141-1144
Number of pages4
JournalThyroid
Volume13
Issue number12
DOIs
StatePublished - Jan 1 2003

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Graves Ophthalmopathy
Optic Nerve Diseases
Decompression
Control Groups
Odds Ratio
Documentation
Autoimmune Diseases
Thyroid Gland
Referral and Consultation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Fatourechi, V., Bartley, G. B., Eghbali-Fatourechi, G. Z., Powell, C. C., Ahmed, D. D. F., & Garrity, J. A. (2003). Graves' Dermopathy and Acropachy Are Markers of Severe Graves' Ophthalmopathy. Thyroid, 13(12), 1141-1144. https://doi.org/10.1089/10507250360731541

Graves' Dermopathy and Acropachy Are Markers of Severe Graves' Ophthalmopathy. / Fatourechi, Vahab; Bartley, George B.; Eghbali-Fatourechi, Guiti Z.; Powell, Claudia C.; Ahmed, Debra D.F.; Garrity, James A.

In: Thyroid, Vol. 13, No. 12, 01.01.2003, p. 1141-1144.

Research output: Contribution to journalArticle

Fatourechi, V, Bartley, GB, Eghbali-Fatourechi, GZ, Powell, CC, Ahmed, DDF & Garrity, JA 2003, 'Graves' Dermopathy and Acropachy Are Markers of Severe Graves' Ophthalmopathy', Thyroid, vol. 13, no. 12, pp. 1141-1144. https://doi.org/10.1089/10507250360731541
Fatourechi V, Bartley GB, Eghbali-Fatourechi GZ, Powell CC, Ahmed DDF, Garrity JA. Graves' Dermopathy and Acropachy Are Markers of Severe Graves' Ophthalmopathy. Thyroid. 2003 Jan 1;13(12):1141-1144. https://doi.org/10.1089/10507250360731541
Fatourechi, Vahab ; Bartley, George B. ; Eghbali-Fatourechi, Guiti Z. ; Powell, Claudia C. ; Ahmed, Debra D.F. ; Garrity, James A. / Graves' Dermopathy and Acropachy Are Markers of Severe Graves' Ophthalmopathy. In: Thyroid. 2003 ; Vol. 13, No. 12. pp. 1141-1144.
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