Glycemic control and nerve conduction abnormalities in non-insulin-dependent diabetic subjects

R. J. Graf, J. B. Halter, M. A. Pfeifer, E. Halar, F. Brozovich, D. Porte

Research output: Contribution to journalArticle

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Abstract

The influence of therapy of hyperglycemia on the progression of diabetic neuropathy is unclear. We studied variables of glycemia and motor and sensory nerve conduction velocity in a group of 18 non-insulin-dependent diabetic subjects before and after institution of diabetes therapy. Diabetes therapy significantly reduced variables of glycemia after 1, 3, 6 and 12 months. Conduction velocity of the median motor nerve was improved from baseline at each time tested during treatment. In addition, peroneal and tibial motor nerve conduction velocities improved in patients whose levels of hyperglycemia were lowered. Moreover, extent of improvement of conduction velocity of some motor nerves was related to the degree of reduction of hyperglycemia. Sensory nerve conduction velocity was not altered by diabetes therapy. These findings support the hypothesis of a metabolic component to diabetic neuropathy and suggest that optimal glycemia may be beneficial to patients with this disorder.

Original languageEnglish (US)
Pages (from-to)307-311
Number of pages5
JournalAnnals of Internal Medicine
Volume94
Issue number3
StatePublished - 1981
Externally publishedYes

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Neural Conduction
Hyperglycemia
Diabetic Neuropathies
Therapeutics
Tibial Nerve
Median Nerve

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Graf, R. J., Halter, J. B., Pfeifer, M. A., Halar, E., Brozovich, F., & Porte, D. (1981). Glycemic control and nerve conduction abnormalities in non-insulin-dependent diabetic subjects. Annals of Internal Medicine, 94(3), 307-311.

Glycemic control and nerve conduction abnormalities in non-insulin-dependent diabetic subjects. / Graf, R. J.; Halter, J. B.; Pfeifer, M. A.; Halar, E.; Brozovich, F.; Porte, D.

In: Annals of Internal Medicine, Vol. 94, No. 3, 1981, p. 307-311.

Research output: Contribution to journalArticle

Graf, RJ, Halter, JB, Pfeifer, MA, Halar, E, Brozovich, F & Porte, D 1981, 'Glycemic control and nerve conduction abnormalities in non-insulin-dependent diabetic subjects', Annals of Internal Medicine, vol. 94, no. 3, pp. 307-311.
Graf RJ, Halter JB, Pfeifer MA, Halar E, Brozovich F, Porte D. Glycemic control and nerve conduction abnormalities in non-insulin-dependent diabetic subjects. Annals of Internal Medicine. 1981;94(3):307-311.
Graf, R. J. ; Halter, J. B. ; Pfeifer, M. A. ; Halar, E. ; Brozovich, F. ; Porte, D. / Glycemic control and nerve conduction abnormalities in non-insulin-dependent diabetic subjects. In: Annals of Internal Medicine. 1981 ; Vol. 94, No. 3. pp. 307-311.
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