Glucose homeostasis after simultaneous pancreas and kidney transplantation: A comparison of subjects with C-peptide-positive non-type 1 diabetes mellitus and type 1 diabetes mellitus

Harini M Chakkera, Yogish C Kudva, Yu Hui H. Chang, Raymond L. Heilman, Andrew L. Singer, Amit Mathur, Winston R. Hewitt, Hasan A. Khamash, Janna L. Huskey, Nitin N. Katariya, Adyr A. Moss, Senaida Behmen, Kunam Sudhakar Reddy

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background: While simultaneous pancreas kidney transplant (SPKTx) is a therapeutic option for patients with type 1 diabetes (T1DM) and renal failure, few centers offer SPKTx to "select" non-T1DM patients. To address concerns that existing insulin resistance may limit the benefits of the pancreas allograft among non-T1DM, we compared several indices of glucose homeostasis, in "select" non-T1DM and T1DM patients who received SPKTx. Methods: Criteria for "select" non-T1DM included the following: positive C-peptide, BMI 2, treatment with oral agents before insulin initiation, and insulin at

Original languageEnglish (US)
JournalClinical Transplantation
DOIs
StateAccepted/In press - 2015

Keywords

  • Diabetes
  • Insulin resistance
  • Insulin secretion
  • Pancreas transplant

ASJC Scopus subject areas

  • Transplantation

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