Glucocorticoid regulation of rRNA synthesis

Pramod B. Mahajan, E. Aubrey Thompson

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Glucocorticoids inhibit transcription of the genes encoding rRNA (rDNA) in P1798 lymphoma cells. This is due to a decrease in the amount or activity of a transcription factor, called TFIC. TFIC has been purified to apparent homogeneity and the properties of this protein have been investigated in detail. TFIC is tightly associated with RNA polymerase I. The data indicate that TFIC is a bonafide initiation factor that is required for formation of the first phosphodiester bond of nascent pre-rRNA. Extracts from dexamethasone-treated cells are devoid of this factor and cannot form initiated complexes in vitro.

Original languageEnglish (US)
Pages (from-to)195-200
Number of pages6
JournalMolecular and Cellular Biochemistry
Volume104
Issue number1-2
DOIs
StatePublished - May 1 1991

Keywords

  • dexamethasone
  • glucocorticoids
  • rRNA synthesis
  • transcription factors
  • transcription in vitro

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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