Glucocerebrosidase mutations are not a common risk factor for parkinson disease in North Africa

Kenya Nishioka, Carles Vilariño-Güell, Stephanie A. Cobb, Jennifer M. Kachergus, Owen A. Ross, Christian Wider, Rachel A. Gibson, Faycal Hentati, Matthew J. Farrer

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Mutations in the glucocerebrosidase gene (GBA) have recently been associated with an increased risk of Parkinson disease (PD). GBA mutations have been observed to be particularly prevalent in the Ashkenazi Jewish population. Interestingly, this population also has a high incidence of the Lrrk2 p.G2019S mutation which is similar in North African Arab-Berber populations. Herein, our sequencing of the GBA gene, in 33 North African Arab-Berber familial parkinsonism probands, identified two novel mutations in three individuals (p.K-26R and p.K186R). Segregation analysis of these two variants did not support a pathogenic role. Genotyping of p.K-26R, p.K186R and the common p.N370S in an ethnically matched series consisting of 395 patients with PD and 372 control subjects did not show a statistically significant association (P>0.05). The p.N370S mutation was only identified in 1 sporadic patient with PD and 3 control subjects indicating that the frequency of this mutation in the North African Arab-Berber population is much lower than that observed in Ashkenazi Jews, and therefore arose in the latter after expansion of the Lrrk2 p.G2019S variant in North Africa.

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalNeuroscience Letters
Volume477
Issue number2
DOIs
StatePublished - Jun 1 2010

Keywords

  • Gaucher disease
  • Genetics
  • Parkinson disease

ASJC Scopus subject areas

  • Neuroscience(all)

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    Nishioka, K., Vilariño-Güell, C., Cobb, S. A., Kachergus, J. M., Ross, O. A., Wider, C., Gibson, R. A., Hentati, F., & Farrer, M. J. (2010). Glucocerebrosidase mutations are not a common risk factor for parkinson disease in North Africa. Neuroscience Letters, 477(2), 57-60. https://doi.org/10.1016/j.neulet.2009.11.066