GLP-1 at physiological concentrations recruits skeletal and cardiac muscle microvasculature in healthy humans

Sharmila C. Subaran, Matthew A. Sauder, Weidong Chai, Linda A. Jahn, Dale E. Fowler, Kevin W. Aylor, Ananda Basu, Zhenqi Liu

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Muscle microvascular surface area determines substrate and hormonal exchanges between plasma and muscle interstitium. GLP-1 (glucagon-like peptide-1) regulates glucose-dependent insulin secretion and has numerous extrapancreatic effects, including a salutary vascular action. To examine whether GLP-1 recruits skeletal and cardiac muscle microvasculature in healthy humans, 26 overnight-fasted healthy adults received a systemic infusion of GLP-1 (1.2 pmol/kg of body mass per min) for 150 min. Skeletal and cardiac muscle MBV (microvascular blood volume), MFV (microvascular flow velocity) and MBF (microvascular blood flow) were determined at baseline and after 30 and 150 min. Brachial artery diameter and mean flow velocity were measured and total blood flow was calculated before and at the end of the GLP-1 infusion. GLP-1 infusion raised plasma GLP-1 concentrations to the postprandial levels and suppressed plasma glucagon concentrations with a transient increase in plasma insulin concentrations. Skeletal and cardiac muscle MBV and MBF increased significantly at both 30 and 150 min (P<0.05). MFV did not change in skeletal muscle, but decreased slightly in cardiac muscle. GLP-1 infusion significantly increased brachial artery diameter (P<0.005) and flow velocity (P=0.05) at 150 min, resulting in a significant increase in total brachial artery blood flow (P<0.005). We conclude that acute GLP-1 infusion significantly recruits skeletal and cardiac muscle microvasculature in addition to relaxing the conduit artery in healthy humans. This could contribute to increased tissue oxygen, nutrient and insulin delivery and exchange and therefore better prandial glycaemic control and tissue function in humans.

Original languageEnglish (US)
Pages (from-to)163-170
Number of pages8
JournalClinical Science
Volume127
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Glucagon-Like Peptide 1
Microvessels
Myocardium
Skeletal Muscle
Brachial Artery
Blood Flow Velocity
Insulin
Blood Volume
Muscles
Plasma Exchange
Glucagon
Blood Vessels
Meals
Arteries
Oxygen
Glucose
Food

Keywords

  • conduit artery
  • contrast ultrasonography
  • glucagon-like peptide-1 (GLP-1)
  • microvascular recruitment

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Subaran, S. C., Sauder, M. A., Chai, W., Jahn, L. A., Fowler, D. E., Aylor, K. W., ... Liu, Z. (2014). GLP-1 at physiological concentrations recruits skeletal and cardiac muscle microvasculature in healthy humans. Clinical Science, 127(3), 163-170. https://doi.org/10.1042/CS20130708

GLP-1 at physiological concentrations recruits skeletal and cardiac muscle microvasculature in healthy humans. / Subaran, Sharmila C.; Sauder, Matthew A.; Chai, Weidong; Jahn, Linda A.; Fowler, Dale E.; Aylor, Kevin W.; Basu, Ananda; Liu, Zhenqi.

In: Clinical Science, Vol. 127, No. 3, 2014, p. 163-170.

Research output: Contribution to journalArticle

Subaran, SC, Sauder, MA, Chai, W, Jahn, LA, Fowler, DE, Aylor, KW, Basu, A & Liu, Z 2014, 'GLP-1 at physiological concentrations recruits skeletal and cardiac muscle microvasculature in healthy humans', Clinical Science, vol. 127, no. 3, pp. 163-170. https://doi.org/10.1042/CS20130708
Subaran, Sharmila C. ; Sauder, Matthew A. ; Chai, Weidong ; Jahn, Linda A. ; Fowler, Dale E. ; Aylor, Kevin W. ; Basu, Ananda ; Liu, Zhenqi. / GLP-1 at physiological concentrations recruits skeletal and cardiac muscle microvasculature in healthy humans. In: Clinical Science. 2014 ; Vol. 127, No. 3. pp. 163-170.
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