Germ-free mice model for studying host–microbial interactions

Yogesh Bhattarai, Purna C. Kashyap

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Germ-free (GF) mice are a relevant model system to study host–microbial interactions in health and disease. In this chapter, we underscore the importance of using GF mice model to study host–microbial interactions in obesity, immune development and gastrointestinal physiology by reviewing current literature. Furthermore, we also provide a brief protocol on how to setup a gnotobiotic facility in order to properly maintain and assess GF status in mice colonies.

Original languageEnglish (US)
Pages (from-to)123-135
Number of pages13
JournalMethods in Molecular Biology
Volume1438
DOIs
StatePublished - May 1 2016

Keywords

  • Germ-free
  • Gnotobiotic
  • Gut microbiome

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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