Genome-wide screen for stroke

Pilot testing in the siblings with ischemic stroke study (SWISS)

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The results of cohort and twins studies suggest that stroke risk has a genetic component. To prepare for a multicenter linkage study of sibling pairs, we conducted a pilot study in a small number of subjects. Methods: At 3 centers, we tested a strategy for collecting sibling pairs concordant and discordant for ischemic stroke. Local investigators enrolled probands and obtained family histories. Primary proband inclusion criteria were age 18 to 80 years, ischemic stroke within 180 days, and proband report of at least 1 living sibling with a history of stroke. A central office verified sibling concordance by a medical record review and sibling discordance by a structured telephone interview. Results: Nine consecutive probands (median age, 74 years; age range, 57 to 79 years; male, 67%) were enrolled. Requests for medical records forms were sent to 10 potentially concordant siblings; signed forms were returned by 10 siblings (100%). Ten potentially discordant siblings were contacted by telephone; 9 (90%) agreed to a structured telephone interview. For 6 probands (67%), we verified concordance in at least 1 sibling. For all probands, discordance was verified in at least 1 sibling. None of the potentially concordant siblings lived in the same city as the related proband; 6 (67%) lived in the same state. Conclusion: Our procedure for enrolling siblings was widely accepted by nonpatient family members. The Siblings With Ischemic Stroke Study (SWISS) can enroll sibling pairs with ischemic stroke even when siblings are geographically dispersed.

Original languageEnglish (US)
Pages (from-to)276-281
Number of pages6
JournalJournal of Stroke and Cerebrovascular Diseases
Volume9
Issue number6
DOIs
StatePublished - 2000

Fingerprint

Siblings
Stroke
Genome
Medical Records
Interviews
Twin Studies
Telephone
Multicenter Studies
Cohort Studies
Research Personnel

Keywords

  • Cerebral ischemia
  • Cerebrovascular disorders
  • Genetic screening
  • Multicenter studies
  • Pilot projects

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Health Professions(all)

Cite this

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title = "Genome-wide screen for stroke: Pilot testing in the siblings with ischemic stroke study (SWISS)",
abstract = "Background: The results of cohort and twins studies suggest that stroke risk has a genetic component. To prepare for a multicenter linkage study of sibling pairs, we conducted a pilot study in a small number of subjects. Methods: At 3 centers, we tested a strategy for collecting sibling pairs concordant and discordant for ischemic stroke. Local investigators enrolled probands and obtained family histories. Primary proband inclusion criteria were age 18 to 80 years, ischemic stroke within 180 days, and proband report of at least 1 living sibling with a history of stroke. A central office verified sibling concordance by a medical record review and sibling discordance by a structured telephone interview. Results: Nine consecutive probands (median age, 74 years; age range, 57 to 79 years; male, 67{\%}) were enrolled. Requests for medical records forms were sent to 10 potentially concordant siblings; signed forms were returned by 10 siblings (100{\%}). Ten potentially discordant siblings were contacted by telephone; 9 (90{\%}) agreed to a structured telephone interview. For 6 probands (67{\%}), we verified concordance in at least 1 sibling. For all probands, discordance was verified in at least 1 sibling. None of the potentially concordant siblings lived in the same city as the related proband; 6 (67{\%}) lived in the same state. Conclusion: Our procedure for enrolling siblings was widely accepted by nonpatient family members. The Siblings With Ischemic Stroke Study (SWISS) can enroll sibling pairs with ischemic stroke even when siblings are geographically dispersed.",
keywords = "Cerebral ischemia, Cerebrovascular disorders, Genetic screening, Multicenter studies, Pilot projects",
author = "Meschia, {James F} and Brott, {Thomas G} and J. Hardy and Brown, {Robert D Jr.} and Dodick, {David William} and Cornwell, {K. B.}",
year = "2000",
doi = "10.1053/jscd.2000.20363",
language = "English (US)",
volume = "9",
pages = "276--281",
journal = "Journal of Stroke and Cerebrovascular Diseases",
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TY - JOUR

T1 - Genome-wide screen for stroke

T2 - Pilot testing in the siblings with ischemic stroke study (SWISS)

AU - Meschia, James F

AU - Brott, Thomas G

AU - Hardy, J.

AU - Brown, Robert D Jr.

AU - Dodick, David William

AU - Cornwell, K. B.

PY - 2000

Y1 - 2000

N2 - Background: The results of cohort and twins studies suggest that stroke risk has a genetic component. To prepare for a multicenter linkage study of sibling pairs, we conducted a pilot study in a small number of subjects. Methods: At 3 centers, we tested a strategy for collecting sibling pairs concordant and discordant for ischemic stroke. Local investigators enrolled probands and obtained family histories. Primary proband inclusion criteria were age 18 to 80 years, ischemic stroke within 180 days, and proband report of at least 1 living sibling with a history of stroke. A central office verified sibling concordance by a medical record review and sibling discordance by a structured telephone interview. Results: Nine consecutive probands (median age, 74 years; age range, 57 to 79 years; male, 67%) were enrolled. Requests for medical records forms were sent to 10 potentially concordant siblings; signed forms were returned by 10 siblings (100%). Ten potentially discordant siblings were contacted by telephone; 9 (90%) agreed to a structured telephone interview. For 6 probands (67%), we verified concordance in at least 1 sibling. For all probands, discordance was verified in at least 1 sibling. None of the potentially concordant siblings lived in the same city as the related proband; 6 (67%) lived in the same state. Conclusion: Our procedure for enrolling siblings was widely accepted by nonpatient family members. The Siblings With Ischemic Stroke Study (SWISS) can enroll sibling pairs with ischemic stroke even when siblings are geographically dispersed.

AB - Background: The results of cohort and twins studies suggest that stroke risk has a genetic component. To prepare for a multicenter linkage study of sibling pairs, we conducted a pilot study in a small number of subjects. Methods: At 3 centers, we tested a strategy for collecting sibling pairs concordant and discordant for ischemic stroke. Local investigators enrolled probands and obtained family histories. Primary proband inclusion criteria were age 18 to 80 years, ischemic stroke within 180 days, and proband report of at least 1 living sibling with a history of stroke. A central office verified sibling concordance by a medical record review and sibling discordance by a structured telephone interview. Results: Nine consecutive probands (median age, 74 years; age range, 57 to 79 years; male, 67%) were enrolled. Requests for medical records forms were sent to 10 potentially concordant siblings; signed forms were returned by 10 siblings (100%). Ten potentially discordant siblings were contacted by telephone; 9 (90%) agreed to a structured telephone interview. For 6 probands (67%), we verified concordance in at least 1 sibling. For all probands, discordance was verified in at least 1 sibling. None of the potentially concordant siblings lived in the same city as the related proband; 6 (67%) lived in the same state. Conclusion: Our procedure for enrolling siblings was widely accepted by nonpatient family members. The Siblings With Ischemic Stroke Study (SWISS) can enroll sibling pairs with ischemic stroke even when siblings are geographically dispersed.

KW - Cerebral ischemia

KW - Cerebrovascular disorders

KW - Genetic screening

KW - Multicenter studies

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DO - 10.1053/jscd.2000.20363

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