Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

GliomaScan Consortium

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65 Citations (Scopus)

Abstract

Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10-9, odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10-10, OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10-8, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10-11, OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10-10, OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10-9, OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10-10, OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10-10, OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10-9, OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10-8, OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10-10, OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10-11, OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10-9, OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.

Original languageEnglish (US)
JournalNature Genetics
DOIs
StateAccepted/In press - Mar 27 2017

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Genome-Wide Association Study
Genetic Predisposition to Disease
Glioblastoma
Glioma
Odds Ratio
Neoplasms
Meta-Analysis

ASJC Scopus subject areas

  • Genetics

Cite this

@article{e003967564104636b3fcc605b9933d72,
title = "Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors",
abstract = "Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10-9, odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10-10, OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10-8, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10-11, OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10-10, OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10-9, OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10-10, OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10-10, OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10-9, OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10-8, OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10-10, OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10-11, OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10-9, OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.",
author = "{GliomaScan Consortium} and Melin, {Beatrice S.} and Barnholtz-Sloan, {Jill S.} and Wrensch, {Margaret R.} and Christoffer Johansen and Dora Il'yasova and Ben Kinnersley and Ostrom, {Quinn T.} and Karim Labreche and Yanwen Chen and Georgina Armstrong and Yanhong Liu and Eckel-Passow, {Jeanette E} and Decker, {Paul A.} and Marianne Labussi{\`e}re and Ahmed Idbaih and Khe Hoang-Xuan and {Di Stefano}, {Anna Luisa} and Karima Mokhtari and Delattre, {Jean Yves} and Peter Broderick and Pilar Galan and Konstantinos Gousias and Johannes Schramm and Schoemaker, {Minouk J.} and Fleming, {Sarah J.} and Stefan Herms and Stefanie Heilmann and N{\"o}then, {Markus M.} and Wichmann, {Heinz Erich} and Stefan Schreiber and Anthony Swerdlow and Mark Lathrop and Matthias Simon and Marc Sanson and Ulrika Andersson and Preetha Rajaraman and Stephen Chanock and Martha Linet and Zhaoming Wang and Meredith Yeager and Wiencke, {John K.} and Helen Hansen and Lucie McCoy and Terri Rice and Kosel, {Matthew L.} and Hugues Sicotte and Amos, {Christopher I.} and Bernstein, {Jonine L.} and Lachance, {Daniel H} and Jenkins, {Robert Brian}",
year = "2017",
month = "3",
day = "27",
doi = "10.1038/ng.3823",
language = "English (US)",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

AU - GliomaScan Consortium

AU - Melin, Beatrice S.

AU - Barnholtz-Sloan, Jill S.

AU - Wrensch, Margaret R.

AU - Johansen, Christoffer

AU - Il'yasova, Dora

AU - Kinnersley, Ben

AU - Ostrom, Quinn T.

AU - Labreche, Karim

AU - Chen, Yanwen

AU - Armstrong, Georgina

AU - Liu, Yanhong

AU - Eckel-Passow, Jeanette E

AU - Decker, Paul A.

AU - Labussière, Marianne

AU - Idbaih, Ahmed

AU - Hoang-Xuan, Khe

AU - Di Stefano, Anna Luisa

AU - Mokhtari, Karima

AU - Delattre, Jean Yves

AU - Broderick, Peter

AU - Galan, Pilar

AU - Gousias, Konstantinos

AU - Schramm, Johannes

AU - Schoemaker, Minouk J.

AU - Fleming, Sarah J.

AU - Herms, Stefan

AU - Heilmann, Stefanie

AU - Nöthen, Markus M.

AU - Wichmann, Heinz Erich

AU - Schreiber, Stefan

AU - Swerdlow, Anthony

AU - Lathrop, Mark

AU - Simon, Matthias

AU - Sanson, Marc

AU - Andersson, Ulrika

AU - Rajaraman, Preetha

AU - Chanock, Stephen

AU - Linet, Martha

AU - Wang, Zhaoming

AU - Yeager, Meredith

AU - Wiencke, John K.

AU - Hansen, Helen

AU - McCoy, Lucie

AU - Rice, Terri

AU - Kosel, Matthew L.

AU - Sicotte, Hugues

AU - Amos, Christopher I.

AU - Bernstein, Jonine L.

AU - Lachance, Daniel H

AU - Jenkins, Robert Brian

PY - 2017/3/27

Y1 - 2017/3/27

N2 - Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10-9, odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10-10, OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10-8, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10-11, OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10-10, OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10-9, OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10-10, OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10-10, OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10-9, OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10-8, OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10-10, OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10-11, OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10-9, OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.

AB - Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10-9, odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10-10, OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10-8, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10-11, OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10-10, OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10-9, OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10-10, OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10-10, OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10-9, OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10-8, OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10-10, OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10-11, OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10-9, OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.

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U2 - 10.1038/ng.3823

DO - 10.1038/ng.3823

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JF - Nature Genetics

SN - 1061-4036

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