Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus

Chad Garner, Richard Ahn, Yuan Chun Ding, Linda Steele, Samantha Stoven, Peter H. Green, Alessio Fasano, Joseph A. Murray, Susan L. Neuhausen

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28 Scopus citations

Abstract

We performed a genome-wide association study (GWAS) of 1550 North American celiac disease cases and 3084 controls. Twelve SNPs, distributed across four regions (3p21.31, 4q27, 6q15, 6q25), were significantly associated with disease (p-value <1.0×10-7), and a further seven SNPs, across four additional regions (1q24.3, 10p15.1, 6q22.31, 17q21.32) had suggestive evidence (1.0×10-7 < p-value < 1.0×10-6). This study replicated a previous suggestive association within FRMD4B (3p14.1), confirming it as a celiac disease locus. All four regions with significant associations and two regions with suggestive results (1q24.3, 10p15.1) were known disease loci. The 6q22.31 and 10p11.23 regions were not replicated. A total of 410 SNPs distributed across the eight significant and suggestive regions were tested for association with dermatitis herpetiformis and microscopic colitis. Preliminary, suggestive statistical evidence for association with the two traits was found at chromosomes 3p21.31, 6q15, 6q25, 1q24.3 and 10p11.23, with future studies being required to validate the reported associations.

Original languageEnglish (US)
Article numbere101428
JournalPloS one
Volume9
Issue number7
DOIs
StatePublished - Jul 7 2014

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Garner, C., Ahn, R., Ding, Y. C., Steele, L., Stoven, S., Green, P. H., Fasano, A., Murray, J. A., & Neuhausen, S. L. (2014). Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus. PloS one, 9(7), [e101428]. https://doi.org/10.1371/journal.pone.0101428