Genome-wide association study identifies multiple risk loci for renal cell carcinoma

Ghislaine Scelo; Mark P. Purdue; Kevin M. Brown; Mattias Johansson; Zhaoming Wang; Jeanette E. Eckel-Passow; Yuanqing Ye; Jonathan N. Hofmann; Jiyeon Choi; Matthieu Foll; Valerie Gaborieau; Mitchell J. Machiela; Leandro M. Colli; Peng Li; Joshua N. Sampson; Behnoush Abedi-Ardekani; Celine Besse; Helene Blanche; Anne Boland; Laurie Burdette; Amelie Chabrier; Geoffroy Durand; Florence Le Calvez-Kelm; Egor Prokhortchouk; Nivonirina Robinot; Konstantin G. Skryabin; Magdalena B. Wozniak; Meredith Yeager; Gordana Basta-Jovanovic; Zoran Dzamic; Lenka Foretova; Ivana Holcatova; Vladimir Janout; Dana Mates; Anush Mukeriya; Stefan Rascu; David Zaridze; Vladimir Bencko; Cezary Cybulski; Eleonora Fabianova; Viorel Jinga; Jolanta Lissowska; Jan Lubinski; Marie Navratilova; Peter Rudnai; Neonila Szeszenia-Dabrowska; Simone Benhamou; Geraldine Cancel-Tassin; Olivier Cussenot; Laura Baglietto; Heiner Boeing; Kay Tee Khaw; Elisabete Weiderpass; Borje Ljungberg; Raviprakash T. Sitaram; Fiona Bruinsma; Susan J. Jordan; Gianluca Severi; Ingrid Winship; Kristian Hveem; Lars J. Vatten; Tony Fletcher; Kvetoslava Koppova; Susanna C. Larsson; Alicja Wolk; Rosamonde E. Banks; Peter J. Selby; Douglas F. Easton; Paul Pharoah; Gabriella Andreotti; Laura E.Beane Freeman; Stella Koutros; Demetrius Albanes; Satu Männistö; Stephanie Weinstein; Peter E. Clark; Todd L. Edwards; Loren Lipworth; Susan M. Gapstur; Victoria L. Stevens; Hallie Carol; Matthew L. Freedman; Mark M. Pomerantz; Eunyoung Cho; Peter Kraft; Mark A. Preston; Kathryn M. Wilson; J. Michael Gaziano; Howard D. Sesso; Amanda Black; Neal D. Freedman; Wen Yi Huang; John G. Anema; Richard J. Kahnoski; Brian R. Lane; Sabrina L. Noyes; David Petillo; Bin Tean Teh; Ulrike Peters; Emily White; Garnet L. Anderson; Lisa Johnson; Juhua Luo; Julie Buring; I. Min Lee; Wong Ho Chow; Lee E. Moore; Christopher Wood; Timothy Eisen; Marc Henrion; James Larkin; Poulami Barman; Bradley C. Leibovich; Toni K. Choueiri; G. Mark Lathrop; Nathaniel Rothman; Jean Francois Deleuze; James D. McKay; Alexander S. Parker; Xifeng Wu; Richard S. Houlston; Paul Brennan; Stephen J. Chanock

doi:10.1038/ncomms15724

Genome-wide association study identifies multiple risk loci for renal cell carcinoma

Ghislaine Scelo, Mark P. Purdue, Kevin M. Brown, Mattias Johansson, Zhaoming Wang, Jeanette E. Eckel-Passow, Yuanqing Ye, Jonathan N. Hofmann, Jiyeon Choi, Matthieu Foll, Valerie Gaborieau, Mitchell J. Machiela, Leandro M. Colli, Peng Li, Joshua N. Sampson, Behnoush Abedi-Ardekani, Celine Besse, Helene Blanche, Anne Boland, Laurie BurdetteAmelie Chabrier, Geoffroy Durand, Florence Le Calvez-Kelm, Egor Prokhortchouk, Nivonirina Robinot, Konstantin G. Skryabin, Magdalena B. Wozniak, Meredith Yeager, Gordana Basta-Jovanovic, Zoran Dzamic, Lenka Foretova, Ivana Holcatova, Vladimir Janout, Dana Mates, Anush Mukeriya, Stefan Rascu, David Zaridze, Vladimir Bencko, Cezary Cybulski, Eleonora Fabianova, Viorel Jinga, Jolanta Lissowska, Jan Lubinski, Marie Navratilova, Peter Rudnai, Neonila Szeszenia-Dabrowska, Simone Benhamou, Geraldine Cancel-Tassin, Olivier Cussenot, Laura Baglietto, Heiner Boeing, Kay Tee Khaw, Elisabete Weiderpass, Borje Ljungberg, Raviprakash T. Sitaram, Fiona Bruinsma, Susan J. Jordan, Gianluca Severi, Ingrid Winship, Kristian Hveem, Lars J. Vatten, Tony Fletcher, Kvetoslava Koppova, Susanna C. Larsson, Alicja Wolk, Rosamonde E. Banks, Peter J. Selby, Douglas F. Easton, Paul Pharoah, Gabriella Andreotti, Laura E.Beane Freeman, Stella Koutros, Demetrius Albanes, Satu Männistö, Stephanie Weinstein, Peter E. Clark, Todd L. Edwards, Loren Lipworth, Susan M. Gapstur, Victoria L. Stevens, Hallie Carol, Matthew L. Freedman, Mark M. Pomerantz, Eunyoung Cho, Peter Kraft, Mark A. Preston, Kathryn M. Wilson, J. Michael Gaziano, Howard D. Sesso, Amanda Black, Neal D. Freedman, Wen Yi Huang, John G. Anema, Richard J. Kahnoski, Brian R. Lane, Sabrina L. Noyes, David Petillo, Bin Tean Teh, Ulrike Peters, Emily White, Garnet L. Anderson, Lisa Johnson, Juhua Luo, Julie Buring, I. Min Lee, Wong Ho Chow, Lee E. Moore, Christopher Wood, Timothy Eisen, Marc Henrion, James Larkin, Poulami Barman, Bradley C. Leibovich, Toni K. Choueiri, G. Mark Lathrop, Nathaniel Rothman, Jean Francois Deleuze, James D. McKay, Alexander S. Parker, Xifeng Wu, Richard S. Houlston, Paul Brennan, Stephen J. Chanock

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Abstract

Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P = 3.1×10^-10), 3p22.1 (rs67311347, P = 2.5×10^-8), 3q26.2 (rs10936602, P = 8.8×10^-9), 8p21.3 (rs2241261, P = 5.8×10^-9), 10q24.33-q25.1 (rs11813268, P = 3.9×10^-8), 11q22.3 (rs74911261, P = 2.1×10^-10) and 14q24.2 (rs4903064, P = 2.2×10^-24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.

Original language	English (US)
Article number	15724
Journal	Nature communications
Volume	8
DOIs	https://doi.org/10.1038/ncomms15724
State	Published - 2017

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
General
Physics and Astronomy(all)

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Scelo, G., Purdue, M. P., Brown, K. M., Johansson, M., Wang, Z., Eckel-Passow, J. E., Ye, Y., Hofmann, J. N., Choi, J., Foll, M., Gaborieau, V., Machiela, M. J., Colli, L. M., Li, P., Sampson, J. N., Abedi-Ardekani, B., Besse, C., Blanche, H., Boland, A., ... Chanock, S. J. (2017). Genome-wide association study identifies multiple risk loci for renal cell carcinoma. Nature communications, 8, [15724]. https://doi.org/10.1038/ncomms15724

Scelo, G, Purdue, MP, Brown, KM, Johansson, M, Wang, Z, Eckel-Passow, JE, Ye, Y, Hofmann, JN, Choi, J, Foll, M, Gaborieau, V, Machiela, MJ, Colli, LM, Li, P, Sampson, JN, Abedi-Ardekani, B, Besse, C, Blanche, H, Boland, A, Burdette, L, Chabrier, A, Durand, G, Le Calvez-Kelm, F, Prokhortchouk, E, Robinot, N, Skryabin, KG, Wozniak, MB, Yeager, M, Basta-Jovanovic, G, Dzamic, Z, Foretova, L, Holcatova, I, Janout, V, Mates, D, Mukeriya, A, Rascu, S, Zaridze, D, Bencko, V, Cybulski, C, Fabianova, E, Jinga, V, Lissowska, J, Lubinski, J, Navratilova, M, Rudnai, P, Szeszenia-Dabrowska, N, Benhamou, S, Cancel-Tassin, G, Cussenot, O, Baglietto, L, Boeing, H, Khaw, KT, Weiderpass, E, Ljungberg, B, Sitaram, RT, Bruinsma, F, Jordan, SJ, Severi, G, Winship, I, Hveem, K, Vatten, LJ, Fletcher, T, Koppova, K, Larsson, SC, Wolk, A, Banks, RE, Selby, PJ, Easton, DF, Pharoah, P, Andreotti, G, Freeman, LEB, Koutros, S, Albanes, D, Männistö, S, Weinstein, S, Clark, PE, Edwards, TL, Lipworth, L, Gapstur, SM, Stevens, VL, Carol, H, Freedman, ML, Pomerantz, MM, Cho, E, Kraft, P, Preston, MA, Wilson, KM, Gaziano, JM, Sesso, HD, Black, A, Freedman, ND, Huang, WY, Anema, JG, Kahnoski, RJ, Lane, BR, Noyes, SL, Petillo, D, Teh, BT, Peters, U, White, E, Anderson, GL, Johnson, L, Luo, J, Buring, J, Lee, IM, Chow, WH, Moore, LE, Wood, C, Eisen, T, Henrion, M, Larkin, J, Barman, P, Leibovich, BC, Choueiri, TK, Lathrop, GM, Rothman, N, Deleuze, JF, McKay, JD, Parker, AS, Wu, X, Houlston, RS, Brennan, P & Chanock, SJ 2017, 'Genome-wide association study identifies multiple risk loci for renal cell carcinoma', Nature communications, vol. 8, 15724. https://doi.org/10.1038/ncomms15724

@article{af91d95a55384bb983ef8f2d0d4a6b7d,

title = "Genome-wide association study identifies multiple risk loci for renal cell carcinoma",

abstract = "Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P = 3.1×10-10), 3p22.1 (rs67311347, P = 2.5×10-8), 3q26.2 (rs10936602, P = 8.8×10-9), 8p21.3 (rs2241261, P = 5.8×10-9), 10q24.33-q25.1 (rs11813268, P = 3.9×10-8), 11q22.3 (rs74911261, P = 2.1×10-10) and 14q24.2 (rs4903064, P = 2.2×10-24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.",

author = "Ghislaine Scelo and Purdue, {Mark P.} and Brown, {Kevin M.} and Mattias Johansson and Zhaoming Wang and Eckel-Passow, {Jeanette E.} and Yuanqing Ye and Hofmann, {Jonathan N.} and Jiyeon Choi and Matthieu Foll and Valerie Gaborieau and Machiela, {Mitchell J.} and Colli, {Leandro M.} and Peng Li and Sampson, {Joshua N.} and Behnoush Abedi-Ardekani and Celine Besse and Helene Blanche and Anne Boland and Laurie Burdette and Amelie Chabrier and Geoffroy Durand and {Le Calvez-Kelm}, Florence and Egor Prokhortchouk and Nivonirina Robinot and Skryabin, {Konstantin G.} and Wozniak, {Magdalena B.} and Meredith Yeager and Gordana Basta-Jovanovic and Zoran Dzamic and Lenka Foretova and Ivana Holcatova and Vladimir Janout and Dana Mates and Anush Mukeriya and Stefan Rascu and David Zaridze and Vladimir Bencko and Cezary Cybulski and Eleonora Fabianova and Viorel Jinga and Jolanta Lissowska and Jan Lubinski and Marie Navratilova and Peter Rudnai and Neonila Szeszenia-Dabrowska and Simone Benhamou and Geraldine Cancel-Tassin and Olivier Cussenot and Laura Baglietto and Heiner Boeing and Khaw, {Kay Tee} and Elisabete Weiderpass and Borje Ljungberg and Sitaram, {Raviprakash T.} and Fiona Bruinsma and Jordan, {Susan J.} and Gianluca Severi and Ingrid Winship and Kristian Hveem and Vatten, {Lars J.} and Tony Fletcher and Kvetoslava Koppova and Larsson, {Susanna C.} and Alicja Wolk and Banks, {Rosamonde E.} and Selby, {Peter J.} and Easton, {Douglas F.} and Paul Pharoah and Gabriella Andreotti and Freeman, {Laura E.Beane} and Stella Koutros and Demetrius Albanes and Satu M{\"a}nnist{\"o} and Stephanie Weinstein and Clark, {Peter E.} and Edwards, {Todd L.} and Loren Lipworth and Gapstur, {Susan M.} and Stevens, {Victoria L.} and Hallie Carol and Freedman, {Matthew L.} and Pomerantz, {Mark M.} and Eunyoung Cho and Peter Kraft and Preston, {Mark A.} and Wilson, {Kathryn M.} and Gaziano, {J. Michael} and Sesso, {Howard D.} and Amanda Black and Freedman, {Neal D.} and Huang, {Wen Yi} and Anema, {John G.} and Kahnoski, {Richard J.} and Lane, {Brian R.} and Noyes, {Sabrina L.} and David Petillo and Teh, {Bin Tean} and Ulrike Peters and Emily White and Anderson, {Garnet L.} and Lisa Johnson and Juhua Luo and Julie Buring and Lee, {I. Min} and Chow, {Wong Ho} and Moore, {Lee E.} and Christopher Wood and Timothy Eisen and Marc Henrion and James Larkin and Poulami Barman and Leibovich, {Bradley C.} and Choueiri, {Toni K.} and Lathrop, {G. Mark} and Nathaniel Rothman and Deleuze, {Jean Francois} and McKay, {James D.} and Parker, {Alexander S.} and Xifeng Wu and Houlston, {Richard S.} and Paul Brennan and Chanock, {Stephen J.}",

note = "Funding Information: The authors thank all of the participants who took part in this research and the funders and support staff who made this study possible. Funding for the genome-wide genotyping was provided by the US National Institutes of Health (NIH), National Cancer Institute (U01CA155309) for those studies coordinated by IARC and by the intramural research program of the National Cancer Institute, US NIH, for those studies coordinated by the NCI. Funding for the IARC gene expression and eQTL study was provided by the US National Institutes of Health (NIH), National Cancer Institute (U01CA155309). Additional acknowledgements can be found in Supplementary Note. Publisher Copyright: {\textcopyright} The Author(s) 2017.",

year = "2017",

doi = "10.1038/ncomms15724",

language = "English (US)",

volume = "8",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Genome-wide association study identifies multiple risk loci for renal cell carcinoma

AU - Scelo, Ghislaine

AU - Purdue, Mark P.

AU - Brown, Kevin M.

AU - Johansson, Mattias

AU - Wang, Zhaoming

AU - Eckel-Passow, Jeanette E.

AU - Ye, Yuanqing

AU - Hofmann, Jonathan N.

AU - Choi, Jiyeon

AU - Foll, Matthieu

AU - Gaborieau, Valerie

AU - Machiela, Mitchell J.

AU - Colli, Leandro M.

AU - Li, Peng

AU - Sampson, Joshua N.

AU - Abedi-Ardekani, Behnoush

AU - Besse, Celine

AU - Blanche, Helene

AU - Boland, Anne

AU - Burdette, Laurie

AU - Chabrier, Amelie

AU - Durand, Geoffroy

AU - Le Calvez-Kelm, Florence

AU - Prokhortchouk, Egor

AU - Robinot, Nivonirina

AU - Skryabin, Konstantin G.

AU - Wozniak, Magdalena B.

AU - Yeager, Meredith

AU - Basta-Jovanovic, Gordana

AU - Dzamic, Zoran

AU - Foretova, Lenka

AU - Holcatova, Ivana

AU - Janout, Vladimir

AU - Mates, Dana

AU - Mukeriya, Anush

AU - Rascu, Stefan

AU - Zaridze, David

AU - Bencko, Vladimir

AU - Cybulski, Cezary

AU - Fabianova, Eleonora

AU - Jinga, Viorel

AU - Lissowska, Jolanta

AU - Lubinski, Jan

AU - Navratilova, Marie

AU - Rudnai, Peter

AU - Szeszenia-Dabrowska, Neonila

AU - Benhamou, Simone

AU - Cancel-Tassin, Geraldine

AU - Cussenot, Olivier

AU - Baglietto, Laura

AU - Boeing, Heiner

AU - Khaw, Kay Tee

AU - Weiderpass, Elisabete

AU - Ljungberg, Borje

AU - Sitaram, Raviprakash T.

AU - Bruinsma, Fiona

AU - Jordan, Susan J.

AU - Severi, Gianluca

AU - Winship, Ingrid

AU - Hveem, Kristian

AU - Vatten, Lars J.

AU - Fletcher, Tony

AU - Koppova, Kvetoslava

AU - Larsson, Susanna C.

AU - Wolk, Alicja

AU - Banks, Rosamonde E.

AU - Selby, Peter J.

AU - Easton, Douglas F.

AU - Pharoah, Paul

AU - Andreotti, Gabriella

AU - Freeman, Laura E.Beane

AU - Koutros, Stella

AU - Albanes, Demetrius

AU - Männistö, Satu

AU - Weinstein, Stephanie

AU - Clark, Peter E.

AU - Edwards, Todd L.

AU - Lipworth, Loren

AU - Gapstur, Susan M.

AU - Stevens, Victoria L.

AU - Carol, Hallie

AU - Freedman, Matthew L.

AU - Pomerantz, Mark M.

AU - Cho, Eunyoung

AU - Kraft, Peter

AU - Preston, Mark A.

AU - Wilson, Kathryn M.

AU - Gaziano, J. Michael

AU - Sesso, Howard D.

AU - Black, Amanda

AU - Freedman, Neal D.

AU - Huang, Wen Yi

AU - Anema, John G.

AU - Kahnoski, Richard J.

AU - Lane, Brian R.

AU - Noyes, Sabrina L.

AU - Petillo, David

AU - Teh, Bin Tean

AU - Peters, Ulrike

AU - White, Emily

AU - Anderson, Garnet L.

AU - Johnson, Lisa

AU - Luo, Juhua

AU - Buring, Julie

AU - Lee, I. Min

AU - Chow, Wong Ho

AU - Moore, Lee E.

AU - Wood, Christopher

AU - Eisen, Timothy

AU - Henrion, Marc

AU - Larkin, James

AU - Barman, Poulami

AU - Leibovich, Bradley C.

AU - Choueiri, Toni K.

AU - Lathrop, G. Mark

AU - Rothman, Nathaniel

AU - Deleuze, Jean Francois

AU - McKay, James D.

AU - Parker, Alexander S.

AU - Wu, Xifeng

AU - Houlston, Richard S.

AU - Brennan, Paul

AU - Chanock, Stephen J.

N1 - Funding Information: The authors thank all of the participants who took part in this research and the funders and support staff who made this study possible. Funding for the genome-wide genotyping was provided by the US National Institutes of Health (NIH), National Cancer Institute (U01CA155309) for those studies coordinated by IARC and by the intramural research program of the National Cancer Institute, US NIH, for those studies coordinated by the NCI. Funding for the IARC gene expression and eQTL study was provided by the US National Institutes of Health (NIH), National Cancer Institute (U01CA155309). Additional acknowledgements can be found in Supplementary Note. Publisher Copyright: © The Author(s) 2017.

PY - 2017

Y1 - 2017

N2 - Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P = 3.1×10-10), 3p22.1 (rs67311347, P = 2.5×10-8), 3q26.2 (rs10936602, P = 8.8×10-9), 8p21.3 (rs2241261, P = 5.8×10-9), 10q24.33-q25.1 (rs11813268, P = 3.9×10-8), 11q22.3 (rs74911261, P = 2.1×10-10) and 14q24.2 (rs4903064, P = 2.2×10-24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.

AB - Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P = 3.1×10-10), 3p22.1 (rs67311347, P = 2.5×10-8), 3q26.2 (rs10936602, P = 8.8×10-9), 8p21.3 (rs2241261, P = 5.8×10-9), 10q24.33-q25.1 (rs11813268, P = 3.9×10-8), 11q22.3 (rs74911261, P = 2.1×10-10) and 14q24.2 (rs4903064, P = 2.2×10-24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.

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UR - http://www.scopus.com/inward/citedby.url?scp=85030655065&partnerID=8YFLogxK

U2 - 10.1038/ncomms15724

DO - 10.1038/ncomms15724

M3 - Article

C2 - 28598434

AN - SCOPUS:85030655065

SN - 2041-1723

VL - 8

JO - Nature Communications

JF - Nature Communications

M1 - 15724

ER -

Genome-wide association study identifies multiple risk loci for renal cell carcinoma

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