TY - JOUR
T1 - Genome-wide association studies in pharmacogenomics
T2 - Successes and lessons
AU - Motsinger-Reif, Alison A.
AU - Jorgenson, Eric
AU - Relling, Mary V.
AU - Kroetz, Deanna L.
AU - Weinshilboum, Richard
AU - Cox, Nancy J.
AU - Roden, Dan M.
PY - 2013/8
Y1 - 2013/8
N2 - OBJECTIVE: As genotyping technology has progressed, genome-wide association studies (GWAS) have matured into efficient and effective tools for mapping genes underlying human phenotypes. METHODS: Recent studies have shown the utility of the GWAS approach for examining pharmacogenomic traits, including drug metabolism, efficacy, and toxicity. RESULTS: Application of GWAS to pharmacogenomic outcomes presents unique challenges and opportunities. CONCLUSION: In the current review, we discuss the potential promises and potential caveats of this approach specifically as it relates to pharmacogenomic studies. Concerns with study design, power and sample size, and analysis are reviewed. We further examine the features of successful pharmacogenomic GWAS, and describe consortia efforts that are likely to expand the reach of pharmacogenomic GWAS in the future.
AB - OBJECTIVE: As genotyping technology has progressed, genome-wide association studies (GWAS) have matured into efficient and effective tools for mapping genes underlying human phenotypes. METHODS: Recent studies have shown the utility of the GWAS approach for examining pharmacogenomic traits, including drug metabolism, efficacy, and toxicity. RESULTS: Application of GWAS to pharmacogenomic outcomes presents unique challenges and opportunities. CONCLUSION: In the current review, we discuss the potential promises and potential caveats of this approach specifically as it relates to pharmacogenomic studies. Concerns with study design, power and sample size, and analysis are reviewed. We further examine the features of successful pharmacogenomic GWAS, and describe consortia efforts that are likely to expand the reach of pharmacogenomic GWAS in the future.
KW - drug metabolism
KW - drug response
KW - genome-wide association
KW - genome-wide association studies
KW - pharmacogenetic
KW - pharmacogenomic
KW - toxicity
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UR - http://www.scopus.com/inward/citedby.url?scp=84872895907&partnerID=8YFLogxK
U2 - 10.1097/FPC.0b013e32833d7b45
DO - 10.1097/FPC.0b013e32833d7b45
M3 - Review article
C2 - 20639796
AN - SCOPUS:84872895907
SN - 1744-6872
VL - 23
SP - 383
EP - 394
JO - Pharmacogenetics and Genomics
JF - Pharmacogenetics and Genomics
IS - 8
ER -