Genetics of restless legs syndrome

Ignacio F. Mata; Cynthia L. Bodkin; Charles H. Adler; Siong Chi Lin; Ryan J. Uitti; Matthew J. Farrer; Zbigniew K. Wszolek

doi:10.1016/j.parkreldis.2005.08.006

Genetics of restless legs syndrome

Ignacio F. Mata, Cynthia L. Bodkin, Charles H. Adler, Siong Chi Lin, Ryan J. Uitti, Matthew J. Farrer, Zbigniew K. Wszolek

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Restless legs syndrome (RLS) is a common disorder, although under-diagnosed, with a prevalence of up to 15% depending on the population sampled. Familial aggregation has been widely shown since Ekbom formerly described the condition in 1960; twin studies support a genetic contribution in the development of this disorder. Molecular genetic approaches have identified three genomic regions in RLS susceptibility, however no specific mutations have yet been identified. Herein, we review the current status of genetics in RLS, providing some methodological guidelines to help future research.

Original language	English (US)
Pages (from-to)	1-7
Number of pages	7
Journal	Parkinsonism and Related Disorders
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/j.parkreldis.2005.08.006
State	Published - Jan 2006

Keywords

Genetics
Restless legs syndrome
Review

ASJC Scopus subject areas

Neurology
Geriatrics and Gerontology
Clinical Neurology

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10.1016/j.parkreldis.2005.08.006

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title = "Genetics of restless legs syndrome",

abstract = "Restless legs syndrome (RLS) is a common disorder, although under-diagnosed, with a prevalence of up to 15% depending on the population sampled. Familial aggregation has been widely shown since Ekbom formerly described the condition in 1960; twin studies support a genetic contribution in the development of this disorder. Molecular genetic approaches have identified three genomic regions in RLS susceptibility, however no specific mutations have yet been identified. Herein, we review the current status of genetics in RLS, providing some methodological guidelines to help future research.",

keywords = "Genetics, Restless legs syndrome, Review",

author = "Mata, {Ignacio F.} and Bodkin, {Cynthia L.} and Adler, {Charles H.} and Lin, {Siong Chi} and Uitti, {Ryan J.} and Farrer, {Matthew J.} and Wszolek, {Zbigniew K.}",

note = "Funding Information: This work was partially supported by the Morris K. Udall PD Center of Excellence grant awarded to the Mayo Clinic Jacksonville. We would like to thank our study coordinators, Ms J. Searcy, A. Strongosky, T. Radam, and A. Metcalf who help us to collect samples from RLS patients and controls. ",

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AU - Bodkin, Cynthia L.

AU - Adler, Charles H.

AU - Lin, Siong Chi

AU - Uitti, Ryan J.

AU - Farrer, Matthew J.

AU - Wszolek, Zbigniew K.

N1 - Funding Information: This work was partially supported by the Morris K. Udall PD Center of Excellence grant awarded to the Mayo Clinic Jacksonville. We would like to thank our study coordinators, Ms J. Searcy, A. Strongosky, T. Radam, and A. Metcalf who help us to collect samples from RLS patients and controls.

PY - 2006/1

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N2 - Restless legs syndrome (RLS) is a common disorder, although under-diagnosed, with a prevalence of up to 15% depending on the population sampled. Familial aggregation has been widely shown since Ekbom formerly described the condition in 1960; twin studies support a genetic contribution in the development of this disorder. Molecular genetic approaches have identified three genomic regions in RLS susceptibility, however no specific mutations have yet been identified. Herein, we review the current status of genetics in RLS, providing some methodological guidelines to help future research.

AB - Restless legs syndrome (RLS) is a common disorder, although under-diagnosed, with a prevalence of up to 15% depending on the population sampled. Familial aggregation has been widely shown since Ekbom formerly described the condition in 1960; twin studies support a genetic contribution in the development of this disorder. Molecular genetic approaches have identified three genomic regions in RLS susceptibility, however no specific mutations have yet been identified. Herein, we review the current status of genetics in RLS, providing some methodological guidelines to help future research.

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Genetics of restless legs syndrome

Abstract

Keywords

ASJC Scopus subject areas

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