TY - JOUR
T1 - Genetics of irritable bowel syndrome
AU - Saito, Yuri A.
AU - Talley, Nicholas J.
PY - 2008/8
Y1 - 2008/8
N2 - Irritable bowel syndrome (IBS) is one of the most common diagnoses made by gastroenterologists and primary care providers alike, and yet the underlying mechanism remains poorly understood. Family and twin studies suggest that IBS may have a genetic basis. Several candidate gene association studies have been performed, but thus far, they have failed to clearly identify an "IBS gene." Epidemiological studies are needed to facilitate phenotype definition and identify relevant environment risk factors that will need to factor in gene and environment interactions in all future genetic studies. As genetic research in IBS is relatively nascent, much opportunity, as well as many challenges, exists in identifying the genes responsible for IBS.
AB - Irritable bowel syndrome (IBS) is one of the most common diagnoses made by gastroenterologists and primary care providers alike, and yet the underlying mechanism remains poorly understood. Family and twin studies suggest that IBS may have a genetic basis. Several candidate gene association studies have been performed, but thus far, they have failed to clearly identify an "IBS gene." Epidemiological studies are needed to facilitate phenotype definition and identify relevant environment risk factors that will need to factor in gene and environment interactions in all future genetic studies. As genetic research in IBS is relatively nascent, much opportunity, as well as many challenges, exists in identifying the genes responsible for IBS.
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U2 - 10.1111/j.1572-0241.2008.02048.x
DO - 10.1111/j.1572-0241.2008.02048.x
M3 - Review article
C2 - 18684190
AN - SCOPUS:49349096750
SN - 0002-9270
VL - 103
SP - 2100
EP - 2104
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 8
ER -