Genetics of irritable bowel syndrome

Yuri Ann Saito Loftus, Nicholas J. Talley

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Irritable bowel syndrome (IBS) is one of the most common diagnoses made by gastroenterologists and primary care providers alike, and yet the underlying mechanism remains poorly understood. Family and twin studies suggest that IBS may have a genetic basis. Several candidate gene association studies have been performed, but thus far, they have failed to clearly identify an "IBS gene." Epidemiological studies are needed to facilitate phenotype definition and identify relevant environment risk factors that will need to factor in gene and environment interactions in all future genetic studies. As genetic research in IBS is relatively nascent, much opportunity, as well as many challenges, exists in identifying the genes responsible for IBS.

Original languageEnglish (US)
Pages (from-to)2100-2104
Number of pages5
JournalAmerican Journal of Gastroenterology
Volume103
Issue number8
DOIs
StatePublished - Aug 2008

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Irritable Bowel Syndrome
Gene-Environment Interaction
Genetic Research
Twin Studies
Genetic Association Studies
Genes
Epidemiologic Studies
Primary Health Care
Phenotype

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Genetics of irritable bowel syndrome. / Saito Loftus, Yuri Ann; Talley, Nicholas J.

In: American Journal of Gastroenterology, Vol. 103, No. 8, 08.2008, p. 2100-2104.

Research output: Contribution to journalArticle

Saito Loftus, Yuri Ann ; Talley, Nicholas J. / Genetics of irritable bowel syndrome. In: American Journal of Gastroenterology. 2008 ; Vol. 103, No. 8. pp. 2100-2104.
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