Genetics of f1 hybrid susceptibility to myeloma grafts

Larry R. Pease, Morris Foster

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The genetics of hybrid susceptibility to parental myeloma transplants in histocompatible F1 hybrids was investigated. Various inbred mouse strains and their descendant congenic lines were crossed with BALB/C mice to produce appropriate F1 hybrids. Genetic inferences were drawn from the comparison of the frequencies of tumor graft takes among congenic combinations. Hybrids containing the C57BL/10 genetic background were less susceptible to myeloma transplants than were hybrids of other genotypes. Both H-2-associated and non-H-2-associated genetic factors played significant roles in determining host susceptibility to the transplants. The D end of the major histocompatibility complex did not play a predominant role in determining hybrid susceptibility in C57BL-derived F1 hybrids.

Original languageEnglish (US)
Pages (from-to)270-272
Number of pages3
JournalTransplantation
Volume27
Issue number4
DOIs
StatePublished - Apr 1979

ASJC Scopus subject areas

  • Transplantation

Fingerprint Dive into the research topics of 'Genetics of f1 hybrid susceptibility to myeloma grafts'. Together they form a unique fingerprint.

  • Cite this