Genetic variants of α-synuclein are not associated with essential tremor

Owen A Ross, Karen N. Conneely, Tao Wang, Carles Vilarino-Guell, Alexandra I. Soto-Ortolaza, Alex Rajput, Zbigniew K Wszolek, Ryan J. Uitti, Elan D. Louis, Lorraine N. Clark, Matthew J. Farrer, Claudia M. Testa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Given the overlap between Parkinson's disease and essential tremor, we examined genetic variants in α-synuclein (SNCA) as risk determinants for essential tremor. Methods: Samples from 661 essential tremor subjects and 1316 control subjects from 4 participating North American sites were included in this study. Parkinson's disease samples (n = 427) were compared against controls. Twenty variants were selected for association analysis within the SNCA locus. Individual logistic regression analyses against essential tremor diagnosis were run for each variant and then combined using meta-analysis. Results: Our results do not show a significant association between variants in the SNCA locus and risk of essential tremor, whereas the established association of SNCA variants with Parkinson's disease risk was observed. Conclusions: Whereas genetic factors are likely to play a large role in essential tremor pathogenesis, our results do not support a role for common SNCA genetic variants in risk for essential tremor.

Original languageEnglish (US)
Pages (from-to)2552-2556
Number of pages5
JournalMovement Disorders
Volume26
Issue number14
DOIs
StatePublished - Dec 2011

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Synucleins
Essential Tremor
Parkinson Disease
Meta-Analysis
Logistic Models
Regression Analysis

Keywords

  • Association studies in genetics
  • Essential tremor
  • Parkinson's disease
  • Parkinsonism
  • Synuclein
  • Tremor

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Ross, O. A., Conneely, K. N., Wang, T., Vilarino-Guell, C., Soto-Ortolaza, A. I., Rajput, A., ... Testa, C. M. (2011). Genetic variants of α-synuclein are not associated with essential tremor. Movement Disorders, 26(14), 2552-2556. https://doi.org/10.1002/mds.23909

Genetic variants of α-synuclein are not associated with essential tremor. / Ross, Owen A; Conneely, Karen N.; Wang, Tao; Vilarino-Guell, Carles; Soto-Ortolaza, Alexandra I.; Rajput, Alex; Wszolek, Zbigniew K; Uitti, Ryan J.; Louis, Elan D.; Clark, Lorraine N.; Farrer, Matthew J.; Testa, Claudia M.

In: Movement Disorders, Vol. 26, No. 14, 12.2011, p. 2552-2556.

Research output: Contribution to journalArticle

Ross, OA, Conneely, KN, Wang, T, Vilarino-Guell, C, Soto-Ortolaza, AI, Rajput, A, Wszolek, ZK, Uitti, RJ, Louis, ED, Clark, LN, Farrer, MJ & Testa, CM 2011, 'Genetic variants of α-synuclein are not associated with essential tremor', Movement Disorders, vol. 26, no. 14, pp. 2552-2556. https://doi.org/10.1002/mds.23909
Ross OA, Conneely KN, Wang T, Vilarino-Guell C, Soto-Ortolaza AI, Rajput A et al. Genetic variants of α-synuclein are not associated with essential tremor. Movement Disorders. 2011 Dec;26(14):2552-2556. https://doi.org/10.1002/mds.23909
Ross, Owen A ; Conneely, Karen N. ; Wang, Tao ; Vilarino-Guell, Carles ; Soto-Ortolaza, Alexandra I. ; Rajput, Alex ; Wszolek, Zbigniew K ; Uitti, Ryan J. ; Louis, Elan D. ; Clark, Lorraine N. ; Farrer, Matthew J. ; Testa, Claudia M. / Genetic variants of α-synuclein are not associated with essential tremor. In: Movement Disorders. 2011 ; Vol. 26, No. 14. pp. 2552-2556.
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