TY - BOOK
T1 - Genetic variants in Alzheimer's disease
AU - Morgan, Kevin
AU - Carrasquillo, Minerva M.
N1 - Publisher Copyright:
© 2013 Springer Science+Business Media New York. All rights are reserved.
PY - 2013/4/1
Y1 - 2013/4/1
N2 - Alzheimer's Disease is the most common form of dementia. The disease is characterised by the loss of synapses and neurons in the cerebral cortex and certain subcortical regions. In the last three years, the genetics of Alzheimer's Disease has made significant advances; in fact, one could argue more than in the previous two decades. This has resulted in the identification of nine new genes and perhaps more importantly the realization that new pathways could be involved in the pathogenesis of Alzheimer's. These new pathways are now legitimate targets for therapeutic intervention, which can possibly lead to treatment or a possible cure. The aim of this book is to put all of the recent genetic data on these new genes into context. Different genetic variants will be discussed, as well as biomarkers and future possibilities.
AB - Alzheimer's Disease is the most common form of dementia. The disease is characterised by the loss of synapses and neurons in the cerebral cortex and certain subcortical regions. In the last three years, the genetics of Alzheimer's Disease has made significant advances; in fact, one could argue more than in the previous two decades. This has resulted in the identification of nine new genes and perhaps more importantly the realization that new pathways could be involved in the pathogenesis of Alzheimer's. These new pathways are now legitimate targets for therapeutic intervention, which can possibly lead to treatment or a possible cure. The aim of this book is to put all of the recent genetic data on these new genes into context. Different genetic variants will be discussed, as well as biomarkers and future possibilities.
UR - http://www.scopus.com/inward/record.url?scp=84929534895&partnerID=8YFLogxK
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U2 - 10.1007/978-1-4614-7309-1
DO - 10.1007/978-1-4614-7309-1
M3 - Book
AN - SCOPUS:84929534895
SN - 146147308X
SN - 9781461473084
BT - Genetic variants in Alzheimer's disease
PB - Springer New York
ER -