Genetic susceptibility to chronic lymphocytic leukemia

Susan L. Slager; Neil E. Caporaso; Silvia De Sanjose; Lynn R. Goldin

doi:10.1053/j.seminhematol.2013.09.007

Genetic susceptibility to chronic lymphocytic leukemia

Susan L. Slager, Neil E. Caporaso, Silvia De Sanjose, Lynn R. Goldin

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the West and is an incurable malignancy. No firmly established evidence exists for environmental risk factors in the etiology of CLL. However, CLL is estimated to have one of the highest familial risks for a hematologic malignancy; this along with other evidence strongly supports an inherited genetic component. In the past 5 years, genome-wide association studies (GWAS) have provided the foundation for new avenues in the investigation of pathogenesis of this disease with 22 susceptibility loci currently identified. We review here the advances made in identifying these loci, the potential to translate these findings into clinical practice, and future directions needed to advance our understanding of the genetic susceptibility of CLL.

Original language	English (US)
Pages (from-to)	296-302
Number of pages	7
Journal	Seminars in Hematology
Volume	50
Issue number	4
DOIs	https://doi.org/10.1053/j.seminhematol.2013.09.007
State	Published - Oct 2013

ASJC Scopus subject areas

Hematology

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10.1053/j.seminhematol.2013.09.007

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title = "Genetic susceptibility to chronic lymphocytic leukemia",

abstract = "Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the West and is an incurable malignancy. No firmly established evidence exists for environmental risk factors in the etiology of CLL. However, CLL is estimated to have one of the highest familial risks for a hematologic malignancy; this along with other evidence strongly supports an inherited genetic component. In the past 5 years, genome-wide association studies (GWAS) have provided the foundation for new avenues in the investigation of pathogenesis of this disease with 22 susceptibility loci currently identified. We review here the advances made in identifying these loci, the potential to translate these findings into clinical practice, and future directions needed to advance our understanding of the genetic susceptibility of CLL.",

author = "Slager, {Susan L.} and Caporaso, {Neil E.} and {De Sanjose}, Silvia and Goldin, {Lynn R.}",

note = "Funding Information: Supported in part by the National Cancer Institute/NIH Grants R01 CA11844, R01 CA92153; the Intramural research program of the NIH, NCI. ",

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T1 - Genetic susceptibility to chronic lymphocytic leukemia

AU - Slager, Susan L.

AU - Caporaso, Neil E.

AU - De Sanjose, Silvia

AU - Goldin, Lynn R.

N1 - Funding Information: Supported in part by the National Cancer Institute/NIH Grants R01 CA11844, R01 CA92153; the Intramural research program of the NIH, NCI.

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N2 - Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the West and is an incurable malignancy. No firmly established evidence exists for environmental risk factors in the etiology of CLL. However, CLL is estimated to have one of the highest familial risks for a hematologic malignancy; this along with other evidence strongly supports an inherited genetic component. In the past 5 years, genome-wide association studies (GWAS) have provided the foundation for new avenues in the investigation of pathogenesis of this disease with 22 susceptibility loci currently identified. We review here the advances made in identifying these loci, the potential to translate these findings into clinical practice, and future directions needed to advance our understanding of the genetic susceptibility of CLL.

AB - Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the West and is an incurable malignancy. No firmly established evidence exists for environmental risk factors in the etiology of CLL. However, CLL is estimated to have one of the highest familial risks for a hematologic malignancy; this along with other evidence strongly supports an inherited genetic component. In the past 5 years, genome-wide association studies (GWAS) have provided the foundation for new avenues in the investigation of pathogenesis of this disease with 22 susceptibility loci currently identified. We review here the advances made in identifying these loci, the potential to translate these findings into clinical practice, and future directions needed to advance our understanding of the genetic susceptibility of CLL.

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Genetic susceptibility to chronic lymphocytic leukemia

Abstract

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