Genetic susceptibility to chronic lymphocytic leukemia

Susan L Slager, Neil E. Caporaso, Silvia De Sanjose, Lynn R. Goldin

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the West and is an incurable malignancy. No firmly established evidence exists for environmental risk factors in the etiology of CLL. However, CLL is estimated to have one of the highest familial risks for a hematologic malignancy; this along with other evidence strongly supports an inherited genetic component. In the past 5 years, genome-wide association studies (GWAS) have provided the foundation for new avenues in the investigation of pathogenesis of this disease with 22 susceptibility loci currently identified. We review here the advances made in identifying these loci, the potential to translate these findings into clinical practice, and future directions needed to advance our understanding of the genetic susceptibility of CLL.

Original languageEnglish (US)
Pages (from-to)296-302
Number of pages7
JournalSeminars in Hematology
Volume50
Issue number4
DOIs
StatePublished - Oct 2013

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B-Cell Chronic Lymphocytic Leukemia
Genetic Predisposition to Disease
Genome-Wide Association Study
Hematologic Neoplasms
Leukemia
Neoplasms

ASJC Scopus subject areas

  • Hematology

Cite this

Genetic susceptibility to chronic lymphocytic leukemia. / Slager, Susan L; Caporaso, Neil E.; De Sanjose, Silvia; Goldin, Lynn R.

In: Seminars in Hematology, Vol. 50, No. 4, 10.2013, p. 296-302.

Research output: Contribution to journalArticle

Slager, Susan L ; Caporaso, Neil E. ; De Sanjose, Silvia ; Goldin, Lynn R. / Genetic susceptibility to chronic lymphocytic leukemia. In: Seminars in Hematology. 2013 ; Vol. 50, No. 4. pp. 296-302.
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