Genetic evidence for the involvement of τ in progressive supranuclear palsy

Chris Conrad, Athena Andreadis, John Q. Trojanowski, Dennis W. Dickson, David Kang, Xiaohua Chen, Wigbert Wiederholt, Larry Hansen, Eliezer Masliah, Leon J. Thal, Robert Katzman, Yu Xia, Tsunao Saitoh

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365 Scopus citations

Abstract

A dinucleotide repeat polymorphism in a τ intron was identified and used in a case-control study to analyze, the genetic association of τ with several neurodegenerative diseases with τ pathology. Subjects with the homozygous τ A0 alleles were excessively represented in the progressive supranuclear palsy (PSP) group, compared with the age-matched healthy control group. Consequently, this allele is more frequently found in PSP than in a group of healthy subjects. This trend was not found in Alzheimer's disease or parkinsonism-dementia complex of Guam, both of which are accompanied by major τ pathology. The result suggests a possible involvement of τ in the patbogenesis of PSP.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalAnnals of neurology
Volume41
Issue number2
DOIs
StatePublished - Feb 27 1997

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Conrad, C., Andreadis, A., Trojanowski, J. Q., Dickson, D. W., Kang, D., Chen, X., Wiederholt, W., Hansen, L., Masliah, E., Thal, L. J., Katzman, R., Xia, Y., & Saitoh, T. (1997). Genetic evidence for the involvement of τ in progressive supranuclear palsy. Annals of neurology, 41(2), 277-281. https://doi.org/10.1002/ana.410410222