Genetic determinants of emphysema distribution in the national emphysema treatment trial

Dawn L. DeMo, Craig P. Hersh, Eric A. Hoffman, Augusto A. Litonjua, Ross Lazarus, David Sparrow, Joshua O. Benditt, Gerard Criner, Barry Make, Fernando J. Martinez, Paul D. Scanlon, Frank C. Sciurba, James P. Utz, John J. Reilly, Edwin K. Silverman

Research output: Contribution to journalArticle

120 Scopus citations

Abstract

Rationale: Computed tomography (CT) scanning of the lung may reduce phenotypic heterogeneity in defining subjects with chronic obstructive pulmonary disease (COPD), and allow identification of genetic determinants of emphysema severity and distribution. Objectives: We sought to identify genes associated with CT scan distribution of emphysema in individuals without alpha;1-antitrypsin deficiency but with severe COPD. Methods: We evaluated baseline CT densitometry phenotypes in 282 individuals with emphysema enrolled in the Genetics Ancillary Study of the National Emphysema Treatment Trial, and used regression models to identify genetic variants associated with emphysema distribution. Measurements and Main Results: Emphysema distribution was assessed by twomethods - assessment by radiologists and by computerized density mask quantitation, using a threshold of -950 Hounsfield units. A total of 77 polymorphisms in 20 candidate genes were analyzed for association with distribution of emphysema. GSTP1, EPHX1, and MMP1 polymorphisms were associated with the densitometric, apical-predominant distribution of emphysema (p value range = 0.001-0.050). When an apical-predominant phenotype was defined by the radiologist scoring method, GSTP1 and EPHX1 single-nucleotide polymorphisms were found to be significantly associated. In a case-control analysis of COPD susceptibility limited to cases with densitometric upper-lobe-predominant cases, the EPHX1 His139Arg single-nucleotide polymorphism was associated with COPD (p = 0.005). Conclusions: Apical and basal emphysematous destruction appears to be influenced by different genes. Polymorphisms in the xenobiotic enzymes, GSTP1 and EPHX1, are associated with apical-predominant emphysema. Altered detoxification of cigarette smoke metabolites may contribute to emphysema distribution, and these findings may lead to further insight into genetic determinants of emphysema.

Original languageEnglish (US)
Pages (from-to)42-48
Number of pages7
JournalAmerican journal of respiratory and critical care medicine
Volume176
Issue number1
DOIs
StatePublished - Jul 1 2007

Keywords

  • Association analysis
  • COPD
  • Computed tomography
  • Emphysema
  • Genetics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'Genetic determinants of emphysema distribution in the national emphysema treatment trial'. Together they form a unique fingerprint.

  • Cite this

    DeMo, D. L., Hersh, C. P., Hoffman, E. A., Litonjua, A. A., Lazarus, R., Sparrow, D., Benditt, J. O., Criner, G., Make, B., Martinez, F. J., Scanlon, P. D., Sciurba, F. C., Utz, J. P., Reilly, J. J., & Silverman, E. K. (2007). Genetic determinants of emphysema distribution in the national emphysema treatment trial. American journal of respiratory and critical care medicine, 176(1), 42-48. https://doi.org/10.1164/rccm.200612-1797OC