Mice bearing the I‐A subregion mutation bm12 were immunized and challenged with the α‐subunit of human adult haemoglobin. Under conditions in which parental B6/Kh mice respond, B6.C‐H‐2bm12 mice are inhibited nearly 100% in their ability to respond to challenge to the α‐chain of haemoglobin. D2.GD mice which express a variant Ae (Eβ) polypeptide of the I‐E subregion can respond as well as B10.D2 mice to both subunits (α‐ and β‐) of haemoglobin. These observations as well as other genetic mapping data confirm the I‐A mapping of α‐chain‐specific Ir genes and extend the genetic fine mapping to the Aβ gene within the I‐A subregion or a combinatorial Ia determinant generated by an interaction of Aα and Aβ. In addition they implicate the Ia.8 specificity in determining immune responsiveness to α‐chain determinants.
|Original language||English (US)|
|Number of pages||6|
|Journal||International Journal of Immunogenetics|
|State||Published - Dec 1981|
ASJC Scopus subject areas
- Molecular Biology