Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer

Gary S. Stein, Sayyed K. Zaidi, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je Yong Choi, Syed A. Ali, Sandhya Pande, Mohammad Q. Hassan

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)2016-2026
Number of pages11
JournalJournal of cellular biochemistry
Volume104
Issue number6
DOIs
StatePublished - Aug 15 2008

Keywords

  • Chromatin
  • Epigenetic control
  • Nuclear matrix
  • Nuclear microenvironments
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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