General mechanisms of steroid receptors and receptor coregulator action

David G Monroe, Thomas C. Spelsberg

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Abstract

Sex steroid hormones (e.g. estrogens and androgens) are synthesized from cholesterol in a complex set of reactions and that the intracellular action of these hormones is transmitted through their cognate steroid hormone receptor (e.g. estrogen receptor and androgen receptor, respectively). These receptors contain domains involved in ligand binding, DNA binding and transcriptional activation (AF-1 and AF-2). The transcriptional effects of the steroid hormone receptors are elicited through the recruitment and actions of steroid hormone receptor coactivators and corepressors. It is the actions and interactions of the coregulators that determine the transcriptional outcome of the gene promoter. Steroid responsive genes can be classified as either "primary" or "secondary", depending on the requirement for de novo protein synthesis and the rapidity of the response.

Original languageEnglish (US)
Title of host publicationAdvances in Molecular and Cell Biology
Pages39-48
Number of pages10
Volume34
DOIs
StatePublished - 2004
Externally publishedYes

Publication series

NameAdvances in Molecular and Cell Biology
Volume34
ISSN (Print)15692558

Fingerprint

Steroid Receptors
Hormones
Furylfuramide
Co-Repressor Proteins
Androgen Receptors
Gonadal Steroid Hormones
Estrogen Receptors
Transcriptional Activation
Androgens
Genes
Estrogens
Steroids
Cholesterol
Ligands
DNA
Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Monroe, D. G., & Spelsberg, T. C. (2004). General mechanisms of steroid receptors and receptor coregulator action. In Advances in Molecular and Cell Biology (Vol. 34, pp. 39-48). (Advances in Molecular and Cell Biology; Vol. 34). https://doi.org/10.1016/S1569-2558(03)34003-2

General mechanisms of steroid receptors and receptor coregulator action. / Monroe, David G; Spelsberg, Thomas C.

Advances in Molecular and Cell Biology. Vol. 34 2004. p. 39-48 (Advances in Molecular and Cell Biology; Vol. 34).

Research output: Chapter in Book/Report/Conference proceedingChapter

Monroe, DG & Spelsberg, TC 2004, General mechanisms of steroid receptors and receptor coregulator action. in Advances in Molecular and Cell Biology. vol. 34, Advances in Molecular and Cell Biology, vol. 34, pp. 39-48. https://doi.org/10.1016/S1569-2558(03)34003-2
Monroe DG, Spelsberg TC. General mechanisms of steroid receptors and receptor coregulator action. In Advances in Molecular and Cell Biology. Vol. 34. 2004. p. 39-48. (Advances in Molecular and Cell Biology). https://doi.org/10.1016/S1569-2558(03)34003-2
Monroe, David G ; Spelsberg, Thomas C. / General mechanisms of steroid receptors and receptor coregulator action. Advances in Molecular and Cell Biology. Vol. 34 2004. pp. 39-48 (Advances in Molecular and Cell Biology).
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