Gene transfer approaches to the regulation of vascular cell proliferation.

Z. Yang, R. D. Simari, F. Tanner, D. Stephan, G. J. Nabel, E. G. Nabel

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Considerable progress has been made in identifying potential targets for treating vascular proliferative diseases. In this review, we discuss gene transfer approaches to regulating smooth muscle cell proliferation after vascular injury using the cell cycle specific proteins, p21, delta Rb and HSV-tk. Results from these studies suggest that replicating smooth muscle cells and macrophages are inhibited in vivo in several animal models of restenosis, including hyperlipidaemic vessels. Identification of appropriate vascular diseases and improvements in gene delivery and vectors will require careful optimization in order to develop effective molecular therapies for human vascular diseases.

Original languageEnglish (US)
Pages (from-to)181-184
Number of pages4
JournalSeminars in interventional cardiology : SIIC
Volume1
Issue number3
StatePublished - Sep 1996
Externally publishedYes

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Vascular Diseases
Blood Vessels
Cell Proliferation
Smooth Muscle Myocytes
Genes
Cell Cycle Proteins
Vascular System Injuries
Animal Models
Macrophages
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Yang, Z., Simari, R. D., Tanner, F., Stephan, D., Nabel, G. J., & Nabel, E. G. (1996). Gene transfer approaches to the regulation of vascular cell proliferation. Seminars in interventional cardiology : SIIC, 1(3), 181-184.

Gene transfer approaches to the regulation of vascular cell proliferation. / Yang, Z.; Simari, R. D.; Tanner, F.; Stephan, D.; Nabel, G. J.; Nabel, E. G.

In: Seminars in interventional cardiology : SIIC, Vol. 1, No. 3, 09.1996, p. 181-184.

Research output: Contribution to journalArticle

Yang, Z, Simari, RD, Tanner, F, Stephan, D, Nabel, GJ & Nabel, EG 1996, 'Gene transfer approaches to the regulation of vascular cell proliferation.', Seminars in interventional cardiology : SIIC, vol. 1, no. 3, pp. 181-184.
Yang Z, Simari RD, Tanner F, Stephan D, Nabel GJ, Nabel EG. Gene transfer approaches to the regulation of vascular cell proliferation. Seminars in interventional cardiology : SIIC. 1996 Sep;1(3):181-184.
Yang, Z. ; Simari, R. D. ; Tanner, F. ; Stephan, D. ; Nabel, G. J. ; Nabel, E. G. / Gene transfer approaches to the regulation of vascular cell proliferation. In: Seminars in interventional cardiology : SIIC. 1996 ; Vol. 1, No. 3. pp. 181-184.
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