Gene transfer approaches to enhancing bone healing

Oliver Betz, Mark Vrahas, Axel Baltzer, Jay R. Lieberman, Paul D. Robbins, Christopher H. Evans

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Abstract

Although bone is one of the few organs in the body that can heal spontaneously and restore function without scarring, it has been recognized since the time of Hippocrates that repair is not always satisfactory.Bone healing is inadequate when the loss of bone through, for example, tumor resection or traumatic injury, is extensive enough to produce a critical-sized defect.Healing may also be impaired in much smaller defects, and nonunion following fracture occurs in 5-10%of cases (1-3).

Original languageEnglish (US)
Title of host publicationBone Regeneration and Repair
Subtitle of host publicationBiology and Clinical Applications
PublisherHumana Press
Pages157-168
Number of pages12
ISBN (Print)0896038475, 9780896038479
DOIs
StatePublished - Dec 1 2005

ASJC Scopus subject areas

  • Medicine(all)

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    Betz, O., Vrahas, M., Baltzer, A., Lieberman, J. R., Robbins, P. D., & Evans, C. H. (2005). Gene transfer approaches to enhancing bone healing. In Bone Regeneration and Repair: Biology and Clinical Applications (pp. 157-168). Humana Press. https://doi.org/10.1385/1-59259-863-3:157