Gene therapy in sports medicine

Chanin Lamsam, Freddie H. Fu, Paul D. Robbins, Christopher H. Evans

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Sports injuries frequently involve tissues that have limited healing capabilities. In order to improve the healing process and thus prevent the serious consequences of injury, it is necessary to understand the molecular and cellular biology of healing. Several growth factors and other cytokines have been identified as important mediators of a successful healing process. Such molecules have promise as novel agents for the treatment of sporting injuries, but there is presently no clinically useful way to deliver them. Gene transfer may be used to serve this purpose. In this role, gene therapy functions as a type of local biological drug delivery system. Recent studies have shown the feasibility of transferring marker genes to synovium, chondrocytes, meniscal fibrochondrocytes, tenocytes and ligamental fibroblasts, prompting optimism about the eventual success of this approach.

Original languageEnglish (US)
Pages (from-to)73-77
Number of pages5
JournalSports Medicine
Volume25
Issue number2
DOIs
StatePublished - Mar 19 1998

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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