Gene therapy in sports medicine

Christian Lattermann, Axel W A Baltzer, Janey D. Whalen, Christopher H Evans, Paul D. Robbins, Freddie H. Fu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In sports injuries, the most commonly injured tissues, including cartilage, tendons, and certain ligaments, are limited in their ability to heal. A number of growth factors show promise as agents that may improve healing, but their potential clinical use is limited by delivery problems. Gene transfer technologies offer new ways to deliver growth factors and other useful products locally, in a sustained fashion, to tissues that have a restricted healing capacity. Gene transfer circumvents problems that result from the relatively short half-lives of the gene products and can be accomplished by in vivo and ex vivo procedures using a variety of different vector systems. Promising preliminary data have been published indicating the feasibility of transferring genes to bone, cartilage, ligament, and tendon. These data permit cautious optimism that gene therapy will be clinically used in the treatment of certain sporting injuries.

Original languageEnglish (US)
Pages (from-to)83-88
Number of pages6
JournalSports Medicine and Arthroscopy Review
Volume6
Issue number2
StatePublished - 1998
Externally publishedYes

Fingerprint

Sports Medicine
Genetic Therapy
Ligaments
Tendons
Genes
Cartilage
Intercellular Signaling Peptides and Proteins
Technology Transfer
Athletic Injuries
Aptitude
Bone and Bones
Wounds and Injuries
Therapeutics

Keywords

  • Biologic healing
  • Cytokines
  • Gene therapy
  • Growth factors
  • Sports medicine

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Lattermann, C., Baltzer, A. W. A., Whalen, J. D., Evans, C. H., Robbins, P. D., & Fu, F. H. (1998). Gene therapy in sports medicine. Sports Medicine and Arthroscopy Review, 6(2), 83-88.

Gene therapy in sports medicine. / Lattermann, Christian; Baltzer, Axel W A; Whalen, Janey D.; Evans, Christopher H; Robbins, Paul D.; Fu, Freddie H.

In: Sports Medicine and Arthroscopy Review, Vol. 6, No. 2, 1998, p. 83-88.

Research output: Contribution to journalArticle

Lattermann, C, Baltzer, AWA, Whalen, JD, Evans, CH, Robbins, PD & Fu, FH 1998, 'Gene therapy in sports medicine', Sports Medicine and Arthroscopy Review, vol. 6, no. 2, pp. 83-88.
Lattermann C, Baltzer AWA, Whalen JD, Evans CH, Robbins PD, Fu FH. Gene therapy in sports medicine. Sports Medicine and Arthroscopy Review. 1998;6(2):83-88.
Lattermann, Christian ; Baltzer, Axel W A ; Whalen, Janey D. ; Evans, Christopher H ; Robbins, Paul D. ; Fu, Freddie H. / Gene therapy in sports medicine. In: Sports Medicine and Arthroscopy Review. 1998 ; Vol. 6, No. 2. pp. 83-88.
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