Abstract
In sports injuries, the most commonly injured tissues, including cartilage, tendons, and certain ligaments, are limited in their ability to heal. A number of growth factors show promise as agents that may improve healing, but their potential clinical use is limited by delivery problems. Gene transfer technologies offer new ways to deliver growth factors and other useful products locally, in a sustained fashion, to tissues that have a restricted healing capacity. Gene transfer circumvents problems that result from the relatively short half-lives of the gene products and can be accomplished by in vivo and ex vivo procedures using a variety of different vector systems. Promising preliminary data have been published indicating the feasibility of transferring genes to bone, cartilage, ligament, and tendon. These data permit cautious optimism that gene therapy will be clinically used in the treatment of certain sporting injuries.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 83-88 |
| Number of pages | 6 |
| Journal | Sports Medicine and Arthroscopy Review |
| Volume | 6 |
| Issue number | 2 |
| State | Published - 1998 |
| Externally published | Yes |
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Keywords
- Biologic healing
- Cytokines
- Gene therapy
- Growth factors
- Sports medicine
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Surgery
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
Gene therapy in sports medicine. / Lattermann, Christian; Baltzer, Axel W A; Whalen, Janey D.; Evans, Christopher H; Robbins, Paul D.; Fu, Freddie H.
In: Sports Medicine and Arthroscopy Review, Vol. 6, No. 2, 1998, p. 83-88.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gene therapy in sports medicine
AU - Lattermann, Christian
AU - Baltzer, Axel W A
AU - Whalen, Janey D.
AU - Evans, Christopher H
AU - Robbins, Paul D.
AU - Fu, Freddie H.
PY - 1998
Y1 - 1998
N2 - In sports injuries, the most commonly injured tissues, including cartilage, tendons, and certain ligaments, are limited in their ability to heal. A number of growth factors show promise as agents that may improve healing, but their potential clinical use is limited by delivery problems. Gene transfer technologies offer new ways to deliver growth factors and other useful products locally, in a sustained fashion, to tissues that have a restricted healing capacity. Gene transfer circumvents problems that result from the relatively short half-lives of the gene products and can be accomplished by in vivo and ex vivo procedures using a variety of different vector systems. Promising preliminary data have been published indicating the feasibility of transferring genes to bone, cartilage, ligament, and tendon. These data permit cautious optimism that gene therapy will be clinically used in the treatment of certain sporting injuries.
AB - In sports injuries, the most commonly injured tissues, including cartilage, tendons, and certain ligaments, are limited in their ability to heal. A number of growth factors show promise as agents that may improve healing, but their potential clinical use is limited by delivery problems. Gene transfer technologies offer new ways to deliver growth factors and other useful products locally, in a sustained fashion, to tissues that have a restricted healing capacity. Gene transfer circumvents problems that result from the relatively short half-lives of the gene products and can be accomplished by in vivo and ex vivo procedures using a variety of different vector systems. Promising preliminary data have been published indicating the feasibility of transferring genes to bone, cartilage, ligament, and tendon. These data permit cautious optimism that gene therapy will be clinically used in the treatment of certain sporting injuries.
KW - Biologic healing
KW - Cytokines
KW - Gene therapy
KW - Growth factors
KW - Sports medicine
UR - http://www.scopus.com/inward/record.url?scp=0348113868&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0348113868&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0348113868
VL - 6
SP - 83
EP - 88
JO - Sports Medicine and Arthroscopy Review
JF - Sports Medicine and Arthroscopy Review
SN - 1062-8592
IS - 2
ER -