Gene therapy for vein graft disease

D. G. Cable, Hartzell V Schaff

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The durability of coronary artery bypass grafting is intrinsically dependent upon the patency of the graft. The long term patency of arterial grafts, in particular internal mammary grafts, has been clearly defined by multiple groups to be greater than 90% at 10-20 years following construction. This has been fully addressed in Chaps. 13 and 14. Moreover, a recent randomized trial between radial artery and saphenous vein grafts demonstrated the superiority of radial artery conduits at 1 year [1].However, certain clinical scenarios require the use of venous grafts. The intrinsic limitations of saphenous vein bypass grafts and the subsequent acceptance of these imperfections guide our clinical decisions in a fundamental fashion. To address these shortcomings in saphenous vein grafts, a growing body of research has endeavored to improve the function of saphenous veins in an attempt to ultimately increase patency rates and durability of the surgical revascularization.

Original languageEnglish (US)
Title of host publicationArterial Grafting for Coronary Artery Bypass Surgery: Second Edition
PublisherSpringer Berlin Heidelberg
Pages311-320
Number of pages10
ISBN (Print)354030083X, 9783540300830
DOIs
StatePublished - 2006

Fingerprint

Genetic Therapy
Veins
Transplants
Saphenous Vein
Radial Artery
Coronary Artery Bypass
Breast
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cable, D. G., & Schaff, H. V. (2006). Gene therapy for vein graft disease. In Arterial Grafting for Coronary Artery Bypass Surgery: Second Edition (pp. 311-320). Springer Berlin Heidelberg. https://doi.org/10.1007/3-540-30084-8_41

Gene therapy for vein graft disease. / Cable, D. G.; Schaff, Hartzell V.

Arterial Grafting for Coronary Artery Bypass Surgery: Second Edition. Springer Berlin Heidelberg, 2006. p. 311-320.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cable, DG & Schaff, HV 2006, Gene therapy for vein graft disease. in Arterial Grafting for Coronary Artery Bypass Surgery: Second Edition. Springer Berlin Heidelberg, pp. 311-320. https://doi.org/10.1007/3-540-30084-8_41
Cable DG, Schaff HV. Gene therapy for vein graft disease. In Arterial Grafting for Coronary Artery Bypass Surgery: Second Edition. Springer Berlin Heidelberg. 2006. p. 311-320 https://doi.org/10.1007/3-540-30084-8_41
Cable, D. G. ; Schaff, Hartzell V. / Gene therapy for vein graft disease. Arterial Grafting for Coronary Artery Bypass Surgery: Second Edition. Springer Berlin Heidelberg, 2006. pp. 311-320
@inbook{ce7fb2195dbb452ab3fae22c8c3520c8,
title = "Gene therapy for vein graft disease",
abstract = "The durability of coronary artery bypass grafting is intrinsically dependent upon the patency of the graft. The long term patency of arterial grafts, in particular internal mammary grafts, has been clearly defined by multiple groups to be greater than 90{\%} at 10-20 years following construction. This has been fully addressed in Chaps. 13 and 14. Moreover, a recent randomized trial between radial artery and saphenous vein grafts demonstrated the superiority of radial artery conduits at 1 year [1].However, certain clinical scenarios require the use of venous grafts. The intrinsic limitations of saphenous vein bypass grafts and the subsequent acceptance of these imperfections guide our clinical decisions in a fundamental fashion. To address these shortcomings in saphenous vein grafts, a growing body of research has endeavored to improve the function of saphenous veins in an attempt to ultimately increase patency rates and durability of the surgical revascularization.",
author = "Cable, {D. G.} and Schaff, {Hartzell V}",
year = "2006",
doi = "10.1007/3-540-30084-8_41",
language = "English (US)",
isbn = "354030083X",
pages = "311--320",
booktitle = "Arterial Grafting for Coronary Artery Bypass Surgery: Second Edition",
publisher = "Springer Berlin Heidelberg",

}

TY - CHAP

T1 - Gene therapy for vein graft disease

AU - Cable, D. G.

AU - Schaff, Hartzell V

PY - 2006

Y1 - 2006

N2 - The durability of coronary artery bypass grafting is intrinsically dependent upon the patency of the graft. The long term patency of arterial grafts, in particular internal mammary grafts, has been clearly defined by multiple groups to be greater than 90% at 10-20 years following construction. This has been fully addressed in Chaps. 13 and 14. Moreover, a recent randomized trial between radial artery and saphenous vein grafts demonstrated the superiority of radial artery conduits at 1 year [1].However, certain clinical scenarios require the use of venous grafts. The intrinsic limitations of saphenous vein bypass grafts and the subsequent acceptance of these imperfections guide our clinical decisions in a fundamental fashion. To address these shortcomings in saphenous vein grafts, a growing body of research has endeavored to improve the function of saphenous veins in an attempt to ultimately increase patency rates and durability of the surgical revascularization.

AB - The durability of coronary artery bypass grafting is intrinsically dependent upon the patency of the graft. The long term patency of arterial grafts, in particular internal mammary grafts, has been clearly defined by multiple groups to be greater than 90% at 10-20 years following construction. This has been fully addressed in Chaps. 13 and 14. Moreover, a recent randomized trial between radial artery and saphenous vein grafts demonstrated the superiority of radial artery conduits at 1 year [1].However, certain clinical scenarios require the use of venous grafts. The intrinsic limitations of saphenous vein bypass grafts and the subsequent acceptance of these imperfections guide our clinical decisions in a fundamental fashion. To address these shortcomings in saphenous vein grafts, a growing body of research has endeavored to improve the function of saphenous veins in an attempt to ultimately increase patency rates and durability of the surgical revascularization.

UR - http://www.scopus.com/inward/record.url?scp=84890241538&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890241538&partnerID=8YFLogxK

U2 - 10.1007/3-540-30084-8_41

DO - 10.1007/3-540-30084-8_41

M3 - Chapter

AN - SCOPUS:84890241538

SN - 354030083X

SN - 9783540300830

SP - 311

EP - 320

BT - Arterial Grafting for Coronary Artery Bypass Surgery: Second Edition

PB - Springer Berlin Heidelberg

ER -