Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain

Winnie S. Liang, Travis Dunckley, Thomas G. Beach, Andrew Grover, Diego Mastroeni, Douglas G. Walker, Richard J. Caselli, Walter A. Kukull, Daniel McKeel, John C. Morris, Christine Hulette, Donald Schmechel, Gene E. Alexander, Eric M. Reiman, Joseph Rogers, Dietrich A. Stephan

Research output: Contribution to journalArticle

141 Scopus citations

Abstract

In this article, we have characterized and compared gene expression profiles from laser capture microdissected neurons in six functionally and anatomically distinct regions from clinically and histopathologically normal aged human brains. These regions, which are also known to be differentially vulnerable to the histopathological and metabolic features of Alzheimer's disease (AD), include the entorhinal cortex and hippocampus (limbic and paralimbic areas vulnerable to early neurofibrillary tangle pathology in AD), posterior cingulate cortex (a paralimbic area vulnerable to early metabolic abnormalities in AD), temporal and prefrontal cortex (unimodal and heteromodal sensory association areas vulnerable to early neuritic plaque pathology in AD), and primary visual cortex (a primary sensory area relatively spared in early AD). These neuronal profiles will provide valuable reference information for future studies of the brain, in normal aging, AD and other neurological and psychiatric disorders.

Original languageEnglish (US)
Pages (from-to)311-322
Number of pages12
JournalPhysiological Genomics
Volume28
Issue number3
DOIs
StatePublished - Feb 12 2007

Keywords

  • Affymetrix microarrays
  • Alzheimer's disease
  • Expression profiling
  • Laser capture microdissection
  • Neuron
  • Transcriptomics

ASJC Scopus subject areas

  • Physiology
  • Genetics

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    Liang, W. S., Dunckley, T., Beach, T. G., Grover, A., Mastroeni, D., Walker, D. G., Caselli, R. J., Kukull, W. A., McKeel, D., Morris, J. C., Hulette, C., Schmechel, D., Alexander, G. E., Reiman, E. M., Rogers, J., & Stephan, D. A. (2007). Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain. Physiological Genomics, 28(3), 311-322. https://doi.org/10.1152/physiolgenomics.00208.2006